Rimantadine hydrochloride blocks the second step of influenza virus uncoating

1980 ◽  
Vol 66 (3) ◽  
pp. 275-282 ◽  
Author(s):  
A. G. Bukrinskaya ◽  
N. K. Vorkunova ◽  
R. A. Narmanbetova
Keyword(s):  
Influenza Virus ◽  
Second Step ◽  
Rimantadine Hydrochloride ◽  
Virus Uncoating

scholarly journals Dual Function of CD81 in Influenza Virus Uncoating and Budding

2013 ◽  
Vol 9 (10) ◽  
pp. e1003701 ◽  
Author(s):  
Jiang He ◽  
Eileen Sun ◽  
Miriam V. Bujny ◽  
Doory Kim ◽  
Michael W. Davidson ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Dual Function ◽  
Virus Uncoating

scholarly journals Influenza Virus Uncoating in Infected Cells and Effect of Rimantadine

1982 ◽  
Vol 60 (1) ◽  
pp. 49-59 ◽  
Author(s):  
A. G. Bukrinskaya ◽  
N. K. Vorkunova ◽  
G. V. Kornilayeva ◽  
R. A. Narmanbetova ◽  
G. K. Vorkunova
Keyword(s):  
Influenza Virus ◽  
Infected Cells ◽  
Virus Uncoating

Temperature Dependence of the Critical Electron Dose for Fatty Acid Monolayers

1982 ◽  
Vol 40 ◽  
pp. 78-79
Author(s):  
Kenneth H. Downing ◽  
Robert M. Glaeser
Keyword(s):  
Electron Beam ◽  
Fatty Acid ◽  
Inelastic Scattering ◽  
Temperature Dependence ◽  
Structural Damage ◽  
Direct Result ◽  
Second Step ◽  
Strong Temperature Dependence ◽  
Electron Dose ◽  
Covalent Bonds

The structural damage of molecules irradiated by electrons is generally considered to occur in two steps. The direct result of inelastic scattering events is the disruption of covalent bonds. Following changes in bond structure, movement of the constituent atoms produces permanent distortions of the molecules. Since at least the second step should show a strong temperature dependence, it was to be expected that cooling a specimen should extend its lifetime in the electron beam. This result has been found in a large number of experiments, but the degree to which cooling the specimen enhances its resistance to radiation damage has been found to vary widely with specimen types.

The Application of Protein A-Gold Immunocytochemistry to Studies of Protein Secretion

1985 ◽  
Vol 43 ◽  
pp. 426-429
Author(s):  
George H. Herbener ◽  
Antonio Nanci ◽  
Moise Bendayan
Keyword(s):  
Tissue Section ◽  
Colloidal Gold ◽  
Unit Area ◽  
Protein A ◽  
Extracellular Proteins ◽  
Gold Complex ◽  
Second Step ◽  
Igg Antibodies ◽  
Tissue Sections ◽  
Antigenic Sites

Protein A-gold immunocytochemistry is a two-step, post-embedding labeling procedure which may be applied to tissue sections to localize intra- and extracellular proteins. The key requisite for immunocytochemistry is the availability of the appropriate antibody to react in an immune response with the antigenic sites on the protein of interest. During the second step, protein A-gold complex is reacted with the antibody. This is a non- specific reaction in that protein A will combine with most IgG antibodies. The ‘label’ visualized in the electron microscope is colloidal gold. Since labeling is restricted to the surface of the tissue section and since colloidal gold is particulate, labeling density, i.e., the number of gold particles per unit area of tissue section, may be quantitated with ease and accuracy.

Sign in / Sign up

Export Citation Format

Share Document