Entry of adult T-cell leukemia-associated virus into human peripheral blood leukocytes

1985 ◽  
Vol 85 (3-4) ◽  
pp. 321-328 ◽  
Author(s):  
T. Goto ◽  
K. Sugita ◽  
S. Imura ◽  
K. Sano ◽  
M. Nakai
Keyword(s):  
T Cell ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Peripheral Blood Leukocytes ◽  
Blood Leukocytes ◽  
Adult T Cell Leukemia

Adult T-Cell Leukemia/Lymphoma in a Peripheral Blood Smear

2003 ◽  
Vol 127 (5) ◽  
pp. 636-636
Author(s):  
Dragos C. Luca ◽  
Carey Z. August ◽  
Elliot Weisenberg
Keyword(s):  
T Cell ◽  
Peripheral Blood ◽  
Blood Smear ◽  
Peripheral Blood Smear ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia

scholarly journals Clinical and in vitro resistance to bexarotene in adult T-cell leukemia: loss of RXR-α receptor

Blood ◽  
2008 ◽  
Vol 112 (6) ◽  
pp. 2484-2488 ◽  
Author(s):  
Julie H. Lin ◽  
Ellen J. Kim ◽  
Anand Bansal ◽  
John Seykora ◽  
Stephen K. Richardson ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Peripheral Blood ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
First Case ◽  
Induced Apoptosis ◽  
Resistant Cells

Abstract The oral rexinoid bexarotene (Targretin) is widely used for treatment of cutaneous T-cell lymphomas (CTCL). We recently reported the first case of adult T-cell leukemia/lymphoma (ATLL) that responded rapidly to combination therapy of bexarotene and interferon (IFN)-α2b with complete clinical response. We demonstrated that bexarotene induced apoptosis of the patient's malignant peripheral blood T-cells in vitro. However, our patient developed skin and nodal relapse 180 days after starting treatment. We now demonstrate that his peripheral blood malignant T cells became resistant to bexarotene-induced apoptosis. We investigated potential mechanisms that may cause aberrations in the retinoid X receptor (RXR) subunits, RXR-α and RXR-β, to account for these findings. Sequence analysis did not reveal acquisition of mutations in the genes encoding RXR-α and RXR-β by resistant cells. We assessed RXR-α and RXR-β expression by Western blot analysis and found that resistant cells had significantly decreased RXR-α expression compared with pretherapy bexarotene-sensitive cells. Our findings indicate that reduced expression of the RXR-α receptor subunit may represent a mechanism for resistance to bexarotene in T-cell malignancies.

scholarly journals Evaluation of lymphocyte-subset of the cerebrospinal fluid and the peripheral blood in a case with adult T-cell leukemia meningitis.

1988 ◽  
Vol 77 (4) ◽  
pp. 587-588 ◽  
Author(s):  
Hideyuki SAWADA ◽  
Fukashi UDAKA ◽  
Masashi FUJITA ◽  
Masakuni KAMEYAMA ◽  
Makoto MATSUI ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
T Cell ◽  
Peripheral Blood ◽  
Lymphocyte Subset ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia

scholarly journals Green Tea Polyphenols Induce Apoptosisin vitroin Peripheral Blood T Lymphocytes of Adult T-Cell Leukemia Patients

2000 ◽  
Vol 91 (1) ◽  
pp. 34-40 ◽  
Author(s):  
Hong-Chuan Li ◽  
Shinji Yashiki ◽  
Junichiro Sonoda ◽  
Hong Lou ◽  
Subrata K. Ghosh ◽  
...  
Keyword(s):  
T Cell ◽  
T Lymphocytes ◽  
Green Tea ◽  
Peripheral Blood ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia

scholarly journals Chromosome studies in adult T-cell leukemia in Japan: significance of trisomy 7

Blood ◽  
1981 ◽  
Vol 58 (3) ◽  
pp. 420-425 ◽  
Author(s):  
Y Ueshima ◽  
S Fukuhara ◽  
T Hattori ◽  
T Uchiyama ◽  
K Takatsuki ◽  
...  
Keyword(s):  
T Cell ◽  
Peripheral Blood ◽  
Sex Chromosome ◽  
Marker Chromosome ◽  
Japanese Patients ◽  
Chromosome Abnormalities ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Abnormal Cells

Abstract Chromosomes were studied in cells from 15 japanese patients with adult T-cell leukemia (ATL). Mitoses were obtained from unstimulated peripheral blood in 12 patients and a lymph node in one patient. In two other patients, mitotic cells were obtained solely from peripheral blood stimulated with phytohemagglutinin (PHA). Chromsomally abnormal cells were seen in 14 of the 15 patients. The abnormal cells had a modal number of chromosomes in near diploid range in 12 patients, and in near triploid and tetraploid range in the remaining 2 patients, respectively. Eight of the nine patients analyzed by Q-banding had clonal chromosome abnormalities. The most common abnormality was trisomy no.7 or 7q, which was seen in 5 cases and has been primarily observed in lymphoid neoplasms. A 14q+ marker chromosome was found in two patients and a Dq+ in one patient; loss of a sex chromosome was found in three patients. Most chromosomes were involved in gains, losses, or structural rearrangements, but abnormalities of no. 11, which have been frequently found in lymphoid malignancies, was not observed in our series. The significance of these chromosome abnormalities is discussed.

Minimal Residual Disease (MRD) in Adult T-Cell Leukemia/Lymphoma (ATLL) Evaluated by HTLV-1 Proviral Load and Soluble IL-2 Receptor Level in Peripheral Blood.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 2821-2821
Author(s):  
Kunihiro Tsukasaki ◽  
Shigeki Takemoto ◽  
Hirokuni Taguchi ◽  
Masato Masuda ◽  
Syuichi Ikeda ◽  
...  
Keyword(s):  
T Cell ◽  
Prognostic Factor ◽  
Disease Activity ◽  
Peripheral Blood ◽  
Proviral Load ◽  
Clinical Relapse ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Hematopoietic Stem ◽  
Adult T Cell Leukemia

Abstract Background: Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell malignancy caused by human T-lymphotropic virus type-1 (HTLV-1). Age, advanced PS, high LDH value, hypercalcemia and multiple visceral involvements were reported as prognostic factors for ATLL. Although initial therapy is often successful for aggressive ATLL with response rate of 50–80%, relapse (Rel) or progressive disease (PD) is frequent with 2 year-survival of 15–45% after chemotherapy or allogeneic hematopoietic stem cell transplantation (allo-HSCT). That means clinical evaluation of response is not sufficient to predict the prognosis of ATLL. HTLV-1 proviral load (PL) and soluble IL-2 receptor (sIL-2R) level have been reported to be associated with disease activity in ATLL. Method: We prospectively analyzed MRD in aggressive ATLL, acute(A)-, lymphoma(L)- or unfavorable chronic(C)-type, by measuring PL and sIL-2R level in peripheral blood, using real time PCR for Tax region of the virus and conventional ELISA, respectively. Results: PL and sIL2-R were measured just before start of therapy and every 2 months for 1 year unless Rel/PD happens in 78 pts. Median survival time was 7.3 months. Before chemotherapy (n=62), PL was high in order of C, A, and L, and sIL-2 level was of A, L and C, respectively. Neither PL nor sIL2-R level at first point was prognostic factor for pts having chemotherapy, while sIL2-R level, but not PL, was a prognostic factor in trend for pts having allo-HSCT (n=16). Median of the follow up for MRD was 4 months in the former and 6 months in the latter, respectively. In general, sequential data of both reflected disease activity in each case. PL and sIL-2R level were lower during complete response (CR) than partial response (PR), and elevated at Rel/PD. In cases with CR after chemotherapy, PL decreased gradually in 2 to 4 months and was still detected at levels of 1 to 10% during CR. In CR cases after HSCT, PL was often not detected (<0.2%) in 2 months, while sIL-2R level was still high probably reflecting GVHD activity. In CR cases with chemotherapy as compared to PR cases, increase in PL and/or sIL-2R level frequently preceded clinical relapse. Conclusions: These results in aggressive ATLL suggest that; 1) sIL2-R level, but not PL, was a potential prognostic factor for pts having HSCT. 2) PL was better than sIL-2R in estimation of MRD after HSCT. 3) Exacerbation of PL and/or sIL2-R was more useful for prediction of relapse in CR cases as compared to PR cases after chemotherapy.

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