Effect of synthetic chicken vasoactive intestinal peptide on pancreatic blood flow and on exocrine and endocrine secretions of the pancreas in dogs

1983 ◽  
Vol 28 (8) ◽  
pp. 724-732 ◽  
Author(s):  
Kazutomo Inoue ◽  
Tamotsu Kawano ◽  
Koichi Shima ◽  
Teruji Kim ◽  
Takashi Suzuki ◽  
...  
Neuropeptides ◽  
1986 ◽  
Vol 7 (3) ◽  
pp. 207-217 ◽  
Author(s):  
Kazutomo Inoue ◽  
Takashi Suzuki ◽  
Takayoshi Tobe ◽  
Haruaki Yajima

2005 ◽  
Vol 131 (1-3) ◽  
pp. 74-81 ◽  
Author(s):  
Masashi Yoneda ◽  
Manabu Goto ◽  
Kimihide Nakamura ◽  
Shiro Yokohama ◽  
Toru Kono ◽  
...  

1979 ◽  
Vol 27 (9) ◽  
pp. 1283-1284 ◽  
Author(s):  
L I Larsson

Immunocytochemical studies habe shown that many peptides which profoundly affect the endocrine and exocrine functions of the pancreas are localized to neurons. In the cat, such peptidergic nerves appear to innervate ganglia, islets and blood vessels of the pancreas, whereas their contributions to exocrine cells are minor. Our studies suggest that pancreatic ganglia represent one major site of action of the peptides and that, in addition, nerves containing the vasoactive intestinal polypeptide and gastrin/CCK-related peptides profoundly affect pancreatic blood flow and insulin secretion, respectively.


1968 ◽  
Vol 3 (2) ◽  
pp. 130-130 ◽  
Author(s):  
A. Kuroda ◽  
Y. Ishihara ◽  
Y. Kobayashi ◽  
H. Shimizu ◽  
K. Uegaki

1988 ◽  
Vol 47 (6) ◽  
pp. 567-574 ◽  
Author(s):  
Linda J. Huffman ◽  
John M. Connors ◽  
Beatrix H. White ◽  
George A. Hedge

1992 ◽  
Vol 263 (1) ◽  
pp. E57-E63 ◽  
Author(s):  
L. Jansson ◽  
S. Sandler

It has recently been shown that selective B-cell toxins alloxan and streptozotocin (STZ) possess marked effects also on the vascular system. To evaluate to what extent changes in blood perfusion of islets induced by alloxan or STZ could be of importance for diabetogenic action of these compounds, we first investigated acute effects of alloxan (75 mg/kg body wt iv) and STZ (40 mg/kg body wt iv) on both whole pancreatic blood flow (PBF) and islet blood flow (IBF) in adult rats. Alloxan caused a marked increase in IBF, which was most pronounced 3 min after administration and remained for 30 min. PBF, however, was decreased 3 min after alloxan administration but was similar to that of control animals from 10 min and onward. These two opposite effects on IBF and PBF caused the fraction of whole PBF diverted through islets to increase from approximately 10 to 50%. Pretreatment with glucose (2 g/kg body wt iv), indomethacin (3.5 mg/kg body wt iv), dimethyl sulfoxide (10 ml/kg body wt ip of a 33% solution), superoxide dismutase (SOD, 1,000 kU/kg body wt iv), NG-methyl-L-arginine (30 mg/kg body wt iv), theophylline (7 mg/kg body wt iv), or terbutaline (1 mg/kg body wt iv) failed to affect stimulation of IBF by alloxan observed at 3 min. SOD was found to exert a marked stimulation of IBF both when given alone and together with alloxan. Alloxan increased IBF and decreased PBF also in a syngeneic pancreaticoduodenal graft in rats but did not affect flow distribution in a perfused pancreas-duodenum preparation.(ABSTRACT TRUNCATED AT 250 WORDS)


1974 ◽  
Vol 348 (1) ◽  
pp. 51-57 ◽  
Author(s):  
Meral T. Ercan ◽  
Naci M. Bor ◽  
Co?kun F. Bekdik ◽  
G�lsen �ner

1979 ◽  
Vol 27 (2) ◽  
pp. 114-118 ◽  
Author(s):  
Thomas A. Broadie ◽  
Mohandas Devedas ◽  
Joseph Rysavy ◽  
Arnold S. Leonard ◽  
John P. Delaney

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