Increasing antidumping effect of intestinal pacing with motor-active agents

1986 ◽  
Vol 31 (4) ◽  
pp. 422-427 ◽  
Author(s):  
Peter D. Morrison ◽  
Keith A. Kelly
Keyword(s):  
1963 ◽  
Vol 158 (3) ◽  
pp. 338-348
Author(s):  
Aydin M. Bilgutay ◽  
Robert Wingrove ◽  
Ward O. Griffen ◽  
Raymond C. Bonnabeau ◽  
Walton C. Lillehei
Keyword(s):  

1983 ◽  
Vol 198 (4) ◽  
pp. 516-524 ◽  
Author(s):  
BRIAN CRANLEY ◽  
KEITH A. KELLY ◽  
LARRY A. MNICHOLS ◽  
LIANG W. VAY
Keyword(s):  

1978 ◽  
Vol 23 (12) ◽  
pp. 1121-1124 ◽  
Author(s):  
Jack Collin ◽  
Keith A. Kelly ◽  
Sidney F. Phillips

1998 ◽  
Vol 114 ◽  
pp. A792
Author(s):  
X.M. Lin ◽  
M. Zhang ◽  
L.J. Peters ◽  
J. Hayes ◽  
J.D.Z. Chen

1983 ◽  
Vol 84 (2) ◽  
pp. 383-387 ◽  
Author(s):  
James M. Becker ◽  
Pierre Sava ◽  
Keith A. Kelly ◽  
Leonid Shturman
Keyword(s):  

2006 ◽  
Vol 84 (6) ◽  
pp. 589-599 ◽  
Author(s):  
Geoffrey Boddy ◽  
A. Willis ◽  
G. Galante ◽  
E.E. Daniel

Pacing of intestinal smooth muscle is driven by a network of cells found in the myenteric plexus called the interstitial cells of Cajal (ICC-MP), which produce a rhythmic pacemaker current. Using intact segments of circular (CM) and longitudinal (LM) muscle from wild-type and W/WV mice, we found that sodium-, chloride-, and mibefradil-sensitive ion channel currents are required for normal pacing to occur. Application of 30 µmol/L and 300 µmol/L lidocaine, 1 mmol/L 4,4′-diisothiocyanatostilbene-2,2′-disulfonic acid (DIDS), 50 nmol/L and 500 nmol/L mibefradil, or low sodium Krebs significantly reduced pacing frequency in LM and CM. However, simultaneously applying DIDS and lidocaine or low sodium Krebs solution did not completely block pacing nor did it have an additive effect. Lidocaine and low sodium Krebs solution also abolished the gradient of pacing frequencies (higher proximally) found throughout the intestine, resulting in a uniform contraction frequency of 30–40/min. In W/WV mice, which lack ICC-MP, application of DIDS and lidocaine had no effect on the robust pacing in LM segments. In conclusion we found that sodium-, chloride-, and mibefradil-sensitive channel activities were required for normal pacing and to maintain the pacing gradient found throughout the intestines in wild-type but not W/WV mice.


2008 ◽  
Vol 19 (2) ◽  
pp. 196-201 ◽  
Author(s):  
Jinsong Liu ◽  
Xian Qiao ◽  
Xiaohua Hou ◽  
J. D. Z. Chen

1994 ◽  
Vol 23 (2) ◽  
pp. 391-402
Author(s):  
Joseph J. Cullen ◽  
Keith A. Kelly
Keyword(s):  

1963 ◽  
Vol 158 (3) ◽  
pp. 338-348 ◽  
Author(s):  
Aydin M. Bilgutay ◽  
Robert Wingrove ◽  
Ward O. Griffen ◽  
Raymond C. Bonnabeau ◽  
Walton C. Lillehei
Keyword(s):  

1998 ◽  
Vol 114 ◽  
pp. A789
Author(s):  
J. Liang ◽  
J.D.Z. Chen
Keyword(s):  

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