Follow-up study of acute hepatitis C

1994 ◽  
Vol 138 (1-2) ◽  
pp. 71-84 ◽  
Author(s):  
D. Tan ◽  
S. W. K. Im ◽  
W. W. Peng ◽  
M. H. Ng
Keyword(s):  
Hepatitis C ◽  
Acute Hepatitis ◽  
Acute Hepatitis C ◽  
Follow Up Study

Long-lasting Imprint in the Soluble Inflammatory Milieu despite Early Treatment of Acute Symptomatic Hepatitis C

2021 ◽  
Author(s):  
Tanvi Khera ◽  
Yanqin Du ◽  
Daniel Todt ◽  
Katja Deterding ◽  
Benedikt Strunz ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Acute Hepatitis ◽  
Acute Hepatitis C ◽  
Hepatitis C Infection ◽  
Partial Restoration ◽  
Acute Hcv ◽  
Direct Acting ◽  
Inflammatory Milieu

Abstract Background Treatment with direct acting antivirals (DAAs) in patients with chronic hepatitis C infection leads to partial restoration of soluble inflammatory mediators (SIMs). In contrast, we hypothesized that early DAA treatment of acute hepatitis C with DAAs may normalize most SIMs. Methods In this study, we made use of a unique cohort of acute symptomatic hepatitis C who cleared HCV with a 6-week course of ledipasvir/sofosbuvir. Plasma samples were used for proximity extension assay (PEA) measuring 92 proteins. Results Profound SIM alterations were observed in acute HCV patients, with marked upregulation of IL-6 and CXCL10 while certain mediators were down-regulated (e.g. MCP-4, IL-7). During treatment and follow-up, the majority of SIMs decreased but not all normalized (e.g. CDCP1, IL-18). Of note, SIMs that were down-regulated before DAA treatment remained suppressed while others that were initially unchanged, declined to lower values during treatment and follow-up (e.g.CD244). Conclusions Acute hepatitis C was associated with marked changes in the soluble inflammatory milieu as compared to both chronic hepatitis patients and healthy controls. Whereas early DAA treatment partly normalized this altered signature, long-lasting imprints of HCV remained. Thus, acute HCV-induced changes in the immune system may persist even after a short duration of viremia.

Long-term follow-up after successful interferon therapy of acute hepatitis C

Hepatology ◽  
2004 ◽  
Vol 40 (1) ◽  
pp. 98-107 ◽  
Author(s):  
Johannes Wiegand ◽  
Elmar Jäckel ◽  
Markus Cornberg ◽  
Holger Hinrichsen ◽  
Manfred Dietrich ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Acute Hepatitis ◽  
Interferon Therapy ◽  
Acute Hepatitis C ◽  
Long Term Follow Up

scholarly journals Persistence of viremia and the importance of long-term follow-up after acute hepatitis C infection

Hepatology ◽  
1999 ◽  
Vol 29 (3) ◽  
pp. 908-914 ◽  
Author(s):  
Stephen A. Villano ◽  
David Vlahov ◽  
Kenrad E. Nelson ◽  
Sylvia Cohn ◽  
David L. Thomas
Keyword(s):  
Hepatitis C ◽  
Acute Hepatitis ◽  
Acute Hepatitis C ◽  
Hepatitis C Infection ◽  
Long Term Follow Up

scholarly journals The role of interferon in the treatment of acute hepatitis C

2007 ◽  
Vol 60 (7-8) ◽  
pp. 322-326
Author(s):  
Jasmina Simonovic-Babic ◽  
Dragan Delic ◽  
Neda Svirtlih
Keyword(s):  
Hepatitis C ◽  
Acute Hepatitis ◽  
Acute Phase ◽  
Alanine Aminotransferase ◽  
Chronic Infection ◽  
Interferon Alfa ◽  
Hcv Rna ◽  
Acute Hepatitis C ◽  
The Mean

Introduction. Progression from acute to chronic HCV infection occurs in 50% to 84% of cases. Even the latest approach - combination therapy with pegilated interferon alfa 2-a or 2b and ribavirin - eliminates the virus in only 54% to 56% of cases with chronic infection. The aim of this study is to determine whether treatment during the acute phase prevents the development of chronic infection. Material and methods. Between 2001 and 2004, 27 patients with the diagnosis of acute hepatitis C were treated at the hepatology Department of Institute of Infectious and Tropical Diseases. Among them, 19 were treated with recombinant interferon alfa 2-a. Acute hepatitis C was defined by clinical and laboratory test results and by exclusion of other causes of acute liver disease. Results. The mean age of our patients was 32.7 years, whereas the mean incubation time was 61.7 days. The mean serum amino- transferase levels were 1119 U/l and the mean total bilirubin levels were 106 mmol/l. At the end of therapy, 81.8% of patients had undetectable levels of HCV RNA, but 94.7% of patients had normal serum alanine aminotransferase levels. At the end of follow up, 84.6% of patients had normal alanine aminotransferase levels and 83.3% of patients had undetectable levels of HCV RNA. One patient had undetectable antibody to HCV at the end of follow-up. Conclusion. The results reported here demonstrate that in the acute phase of HCV infection, interferon treatment is associated with a high rate of virological and biochemical response. We concluded that early treatment of acute hepatitis C may prevent chronic hepatitis C. .

T.N.36 LONG-TERM FOLLOW UP OF PATIENTS WITH ACUTE HEPATITIS C AND SPONTANEOUS RESOLUTION

2010 ◽  
Vol 42 ◽  
pp. S27-S28
Author(s):  
M. Fasano ◽  
A. Guastadisegni ◽  
A. Volpe ◽  
P. Leone ◽  
V. Racanelli ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Acute Hepatitis ◽  
Spontaneous Resolution ◽  
Acute Hepatitis C ◽  
Long Term Follow Up

scholarly journals Epidemiological characteristics and medical follow-up of 61 patients with acute hepatitis C identified through the hepatitis C surveillance system in France

2007 ◽  
Vol 136 (7) ◽  
pp. 988-996 ◽  
Author(s):  
C. BROUARD ◽  
P. PRADAT ◽  
E. DELAROCQUE-ASTAGNEAU ◽  
C. SILVAIN
Keyword(s):  
Hepatitis C ◽  
Drug Use ◽  
Acute Hepatitis ◽  
Surveillance System ◽  
Spontaneous Clearance ◽  
Acute Hepatitis C ◽  
Medical Procedures ◽  
Invasive Medical Procedures

SUMMARYThis study aimed to describe current epidemiological and clinical characteristics, medical follow-up and outcome in the real practice of acute hepatitis C (AHC) patients. AHC cases were retrospectively identified through the French Hepatology Reference Centres Surveillance system and additional data were collected. Sixty-one patients with AHC were identified (sex ratio: M/F 1·7/1; mean age 39 years). Forty-four (72%) had documented seroconversion within a 6-month period. Main reported risk exposures were intravenous or nasal drug use (35%), invasive medical procedures (25%) and sexual contact with a HCV-positive partner (20%). Spontaneous clearance of HCV RNA was observed in seven out of 16 patients followed without therapy. This study confirms the major role of drug use in HCV transmission and highlights the role of invasive medical procedures and occupational exposure.

scholarly journals Acute hepatitis C virus (HCV) infection in the setting of HIV coinfection: a single-centre 10-year follow-up

2014 ◽  
Vol 17 ◽  
pp. 19638 ◽  
Author(s):  
Patrick Ingiliz ◽  
Katharina Steininger ◽  
Marcel Schuetze ◽  
Stephan Dupke ◽  
Andreas Carganico ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Acute Hepatitis ◽  
Hcv Infection ◽  
Acute Hepatitis C ◽  
Single Centre ◽  
Hiv Coinfection

scholarly journals Characteristics of acute hepatitis C

2014 ◽  
Vol 142 (9-10) ◽  
pp. 564-571
Author(s):  
Nikola Mitrovic ◽  
Natasa Popovic ◽  
Dragan Delic ◽  
Neda Stojkovic-Svirtlih
Keyword(s):  
Risk Factor ◽  
Hepatitis C ◽  
Drug Abuse ◽  
Acute Hepatitis ◽  
Chronic Infection ◽  
Treatment Success ◽  
Young Male ◽  
Treated Group ◽  
Acute Hepatitis C

Introduction. Acute hepatitis C most frequently develops after parenteral infection of hepatitis C virus. The disease often develops into chronic infection, although it can resolve spontaneously. Interferon alpha (INF-?) is used in therapy, but still without precise treatment recommendations. Objective. The aim was to present characteristics of patients with acute hepatitis C and to assess effectiveness of using recombinant INF-? in therapy. Methods. Total of 55 patients with acute hepatitis C, hospitalized at the Clinic for Infectious Diseases in Belgrade from January 2005 to December 2012 were enrolled in this study. Forty-one patients were under follow-up over six months for evaluation of the development of the disease into a chronic infection and effectiveness of treatment with INF-?. Results. Eighty percent of patients were male of average age 29.6?8.6 years; in 61.8% patients intravenous drug abuse was determined as risk factor. Thirty patients (54.1%) had no symptoms and 38.2% were icteric. Acute hepatitis C spontaneously resolved in 33.3% patients, while in the treated group 79.6% of patients completely recovered (p=0.006). Treatment success was 92.9% in the group of patients who started with treatment before the 45th day of disease, while in the patients who started treatment later the success rated 58.3% (p=0.037). Conclusion. Acute hepatitis C is most common in young male adults infected via injection drug abuse. The use of INF-? is effective in the treatment of the disease, and success of the treatment is more probable if treatment is started before the 45th day.

scholarly journals Acute hepatitis C – from the time of diagnosis up to six months of follow-up: a cohort retrospective study

2014 ◽  
Vol 14 (S7) ◽  
Author(s):  
Valeriu Gheorghiță ◽  
Alina Elena Barbu ◽  
Loredana Benea ◽  
Florin Alexandru Căruntu
Keyword(s):  
Retrospective Study ◽  
Hepatitis C ◽  
Acute Hepatitis ◽  
Acute Hepatitis C

Immunological, virological and clinical long-term follow-up after interferon therapy of acute hepatitis C infection

2003 ◽  
Vol 38 ◽  
pp. 181 ◽  
Author(s):  
J. Wiegand ◽  
H.L. Tillmann ◽  
E. Jackel ◽  
M. Cornberg ◽  
M. Dietrich ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Acute Hepatitis ◽  
Interferon Therapy ◽  
Acute Hepatitis C ◽  
Hepatitis C Infection ◽  
Long Term Follow Up
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