Duodenal bicarbonate secretion in humans

1986 ◽  
Vol 31 (S2) ◽  
pp. 130S-130S ◽  
Author(s):  
J. I. Isenberg ◽  
D. L. Hogan ◽  
J. A. Selling ◽  
M. A. Koss
Keyword(s):  
Bicarbonate Secretion ◽  
Duodenal Bicarbonate Secretion

scholarly journals The role of cGMP-cGKI-signaling for duodenal bicarbonate secretion

2009 ◽  
Vol 9 (S1) ◽  
Author(s):  
Beate Spiessberger ◽  
Pascal Weinmeister ◽  
Franz Hofmann ◽  
Claudia Werner ◽  
Dieter Saur ◽  
...  
Keyword(s):  
Bicarbonate Secretion ◽  
Duodenal Bicarbonate Secretion

Neuronal cGMP kinase I is essential for stimulation of duodenal bicarbonate secretion by luminal acid

2012 ◽  
Vol 26 (4) ◽  
pp. 1745-1754 ◽  
Author(s):  
Anurag Kumar Singh ◽  
Beate Spieβberger ◽  
Wen Zheng ◽  
Fang Xiao ◽  
Robert Lukowski ◽  
...  
Keyword(s):  
Bicarbonate Secretion ◽  
Duodenal Bicarbonate Secretion ◽  
Stimulation Of

Su1747 Apical Dopamine D2-Like Receptor Mediated Dopamine-Induced Duodenal Bicarbonate Secretion in Rat

2012 ◽  
Vol 142 (5) ◽  
pp. S-494
Author(s):  
Xiaoyan Feng ◽  
Lifei Zheng ◽  
Xiaofeng Li ◽  
Jin Song ◽  
Yue Zhang ◽  
...  
Keyword(s):  
Bicarbonate Secretion ◽  
Dopamine D2 ◽  
Duodenal Bicarbonate Secretion

W1728 Lubiprostone Stimulates CFTR-Dependent Duodenal Bicarbonate Secretion in Rats

2008 ◽  
Vol 134 (4) ◽  
pp. A-703-A-704
Author(s):  
Misa Mizumori ◽  
Yasutada Akiba ◽  
Jonathan D. Kaunitz
Keyword(s):  
Bicarbonate Secretion ◽  
Duodenal Bicarbonate Secretion

Protein kinase C potentiates cAMP-stimulated mouse duodenal mucosal bicarbonate secretion in vitro

2004 ◽  
Vol 286 (5) ◽  
pp. G814-G821 ◽  
Author(s):  
Bi-Guang Tuo ◽  
Jimmy Y. C. Chow ◽  
Kim E. Barrett ◽  
Jon I. Isenberg
Keyword(s):  
Short Circuit ◽  
Short Circuit Current ◽  
Duodenal Mucosa ◽  
Bicarbonate Secretion ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Ussing Chambers ◽  
Duodenal Bicarbonate Secretion

PKC has been shown to regulate epithelial Cl- secretion in a variety of models. However, the role of PKC in duodenal mucosal bicarbonate secretion is less clear. We aimed to investigate the role of PKC in regulation of duodenal mucosal bicarbonate secretion. Bicarbonate secretion by murine duodenal mucosa was examined in vitro in Ussing chambers using a pH-stat technique. PKC isoform expression and activity were assessed by Western blotting and in vitro kinase assays, respectively. PMA (an activator of PKC) alone had no effect on duodenal bicarbonate secretion or short-circuit current ( Isc). When PMA and dibutyryl-cAMP (db-cAMP) were added simultaneously, PMA failed to alter db-cAMP-stimulated duodenal bicarbonate secretion or Isc ( P > 0.05). However, a 1-h preincubation with PMA potentiated db-cAMP-stimulated duodenal bicarbonate secretion and Isc in a concentration-dependent manner (from 10-8 to 10-5M) ( P < 0.05). PMA preincubation had no effects on carbachol- or heat-stable toxin-stimulated bicarbonate secretion. Western blot analysis revealed that PKCα, -γ, -ϵ, -θ, -μ, and -ι/λ were expressed in murine duodenal mucosa. Ro 31–8220 (an inhibitor active against PKCϵ, -α, -β, and -γ), but not Gö 6983 (an inhibitor active against PKCα, -γ, -β, and -δ), reversed the potentiating effect of PMA on db-cAMP-stimulated bicarbonate secretion. PMA also time- and concentration-dependently increased the activity of PKCϵ, an effect that was prevented by Ro 31–8220 but not Gö 6983. These results demonstrate that activation of PKC potentiates cAMP-stimulated duodenal bicarbonate secretion, whereas it does not modify basal secretion. The effect of PKC on cAMP-stimulated bicarbonate secretion is mediated by the PKCϵ isoform.

Role of Protein Kinases on Acid-Induced Duodenal Bicarbonate Secretion in Rats

2002 ◽  
pp. 139-142
Author(s):  
Osamu Furukawa ◽  
Masahiko Hirokawa ◽  
Paul H. Guth ◽  
Eli Engel ◽  
Jonathan D. Kaunitz
Keyword(s):  
Protein Kinases ◽  
Bicarbonate Secretion ◽  
Duodenal Bicarbonate Secretion
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