Hepatic [14C]aminopyrine demethylation capacity after portocaval shunting

1993 ◽  
Vol 38 (12) ◽  
pp. 2177-2182 ◽  
Author(s):  
Yves Horsmans ◽  
Dominique Lejeune ◽  
Andr� Pierre Geubel ◽  
Jean-Bernard Otte ◽  
Stanislas Pauwels
Keyword(s):  
Aminopyrine Demethylation

Comparison of various doses of carbon 13-labeled aminopyrine for a carbon 13-labeled aminopyrine demethylation blood test in healthy dogs

2006 ◽  
Vol 67 (7) ◽  
pp. 1110-1114 ◽  
Author(s):  
E. Michael Moeller ◽  
Jörg M. Steiner ◽  
David A. Williams ◽  
Mark Tetrick ◽  
John Burr
Keyword(s):  
Blood Test ◽  
Healthy Dogs ◽  
Aminopyrine Demethylation

scholarly journals Effect of gum Arabic on aminopyrine demethylation in rats

1978 ◽  
Vol 34 (12) ◽  
pp. 1609-1610 ◽  
Author(s):  
W. K. Lutz ◽  
E. Brändle ◽  
G. Zbinden
Keyword(s):  
Gum Arabic ◽  
Aminopyrine Demethylation

Recovery of liver function in partially hepatectomized rats evaluated by aminopyrine demethylation capacity

Hepatology ◽  
1985 ◽  
Vol 5 (4) ◽  
pp. 629-633 ◽  
Author(s):  
I. Sendama ◽  
B. de Hemptinne ◽  
L. Lambotte
Keyword(s):  
Liver Function ◽  
Aminopyrine Demethylation

Hepatic Metabolism of Aminopyrine in Patients with Chronic Renal Failure

1978 ◽  
Vol 54 (2) ◽  
pp. 133-140 ◽  
Author(s):  
S. Scherrer ◽  
B. Haldimann ◽  
A. Küpfer ◽  
F. Reubi ◽  
J. Bircher
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Renal Insufficiency ◽  
Serum Creatinine ◽  
Hepatic Metabolism ◽  
Normal Subjects ◽  
Hepatic Disease ◽  
Dialysis Treatment ◽  
History Of ◽  
Aminopyrine Demethylation

1. To evaluate potential alterations in hepatic metabolism of drugs occurring in patients with renal insufficiency the fate of aminopyrine was studied in 17 patients with chronic renal failure and in 27 normal subjects. 2. Although patients with chronic renal failure exhibited large variations, their aminopyrine plasma disappearance times (mean 0·62 ± sd 0·24 h−1) were significantly higher than those found in normal subjects (0·30 ± 0·07 h−1, P < 0·002). 3. 14CO2 derived from [dimethylamine-14C]aminopyrine disappeared from breath more rapidly in patients with chronic renal failure and a history of analgesic abuse (0·40 ± 0·04 h−1) than in control subjects (0·22 ± 0·03 h−1, P < 0·01) and in other patients with chronic renal failure (0·24 ± 0·04 h−1). 4. Dialysis treatment and serum creatinine concentrations were not correlated with the rates of aminopyrine metabolism. Two additional patients, however, with combined renal and hepatic disease, exhibited markedly slowed rates of aminopyrine demethylation. 5. Although chronic renal failure by itself might not alter microsomal drug metabolism it is concluded that, in patients with a history of abuse of phenacetin-containing analgesics, marked acceleration in aminopyrine N-demethylation may be observed.

Renal aminopyrine demethylation in several species determined by a sensitive radiometric method

1984 ◽  
Vol 36 (11) ◽  
pp. 743-747 ◽  
Author(s):  
YASUO OHNO ◽  
TORU KAWANISHI ◽  
ATSUSHI TAKAHASHI ◽  
AKIRA TAKANAKA ◽  
YUTAKA KASUYA ◽  
...  
Keyword(s):  
Radiometric Method ◽  
Aminopyrine Demethylation

Aminopyrine demethylation measured by breath analysis in cirrhosis

1976 ◽  
Vol 20 (4) ◽  
pp. 484-492 ◽  
Author(s):  
Johannes Bircher ◽  
Adrian Küpfer ◽  
Iva Gikalov ◽  
Rudolf Preisig ◽  
Rudolf Preisig
Keyword(s):  
Breath Analysis ◽  
Aminopyrine Demethylation
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