Dopamine and distal colon motility

1979 ◽  
Vol 24 (1) ◽  
pp. 86-87 ◽  
Author(s):  
Fuad Lechin ◽  
Bertha van der Dijs
Keyword(s):  
Distal Colon ◽  
Colon Motility

1080 The Effects of Sympathetic and Parasympathetic Denervation On Distal Colon Motility in Conscious Rats

2009 ◽  
Vol 136 (5) ◽  
pp. A-887
Author(s):  
Timothy J. Ridolfi ◽  
Toku Takahashi ◽  
Lauren Kosinski ◽  
Kirk A. Ludwig
Keyword(s):  
Distal Colon ◽  
Colon Motility ◽  
Conscious Rats

scholarly journals Sacral nerve stimulation with appropriate parameters improves constipation in rats by enhancing colon motility mediated via the autonomic-cholinergic mechanisms

2019 ◽  
Vol 317 (5) ◽  
pp. G609-G617 ◽  
Author(s):  
Zhihui Huang ◽  
Shiying Li ◽  
Robert D. Foreman ◽  
Jieyun Yin ◽  
Ning Dai ◽  
...  
Keyword(s):  
Spectral Analysis ◽  
Fecal Incontinence ◽  
Nerve Stimulation ◽  
Sacral Nerve Stimulation ◽  
Distal Colon ◽  
Colon Motility ◽  
Rectal Compliance ◽  
Sacral Nerve ◽  
Cholinergic Function ◽  
Colon Transit

Although sacral nerve stimulation (SNS) has been applied for treating constipation, its parameters were adopted from SNS for fecal incontinence, its effects are limited, and mechanisms are largely unknown. We investigated the effects and mechanism of SNS with appropriate parameters on constipation in rats treated with loperamide. First, using rectal compliance as an outcome measure, an experiment was performed to derive effective SNS parameters. Then, a 7-day SNS was performed in rats with constipation induced by loperamide. Autonomic functions were assessed by spectral analysis of heart rate variability (HRV) derived from an electrocardiogram. Serum levels of pancreatic polypeptide (PP), norepinephrine (NE), and acetylcholine (ACh) in colon were assessed. 1) Acute SNS at 5 Hz, 100 µs was found effective in enhancing rectal compliance and accelerating distal colon transit ( P < 0.05 vs. sham SNS). 2) The 7-day SNS normalized loperamide-induced constipation, assessed by the number, weight, and water content of fecal pellets, and accelerated the distal colon transit (29.4 ± 3.7 min with sham SNS vs. 16.4 ± 5.3 min with SNS but not gastric emptying or intestinal transit. 3) SNS significantly increased vagal activity ( P = 0.035) and decreased sympathetic activity ( P = 0.012), assessed by spectral analysis of HRV as well as by the serum PP. 4) SNS increased ACh in the colon tissue; atropine blocked the accelerative effect of SNS on distal colon transit. We concluded that SNS with appropriate parameters improves constipation induced by loperamide by accelerating distal colon motility, mediated via the autonomic-cholinergic function. NEW & NOTEWORTHY Although sacral nerve stimulation (SNS) has been applied for treating constipation, its parameters were adopted from SNS for fecal incontinence, effects are limited, and mechanisms are largely unknown. This paper shows that SNS with appropriate parameters improves constipation induced by loperamide by accelerating distal colon motility mediated via the autonomic-cholinergic function.

Estradiol upregulates the expression of oxytocin receptor in colon in rats

2009 ◽  
Vol 296 (5) ◽  
pp. E1059-E1066 ◽  
Author(s):  
Mei Feng ◽  
Junfang Qin ◽  
Chao Wang ◽  
Yanfang Ye ◽  
Shuanglian Wang ◽  
...  
Keyword(s):  
Myenteric Plexus ◽  
Distal Colon ◽  
Colon Motility ◽  
Rt Pcr ◽  
Excitatory Effect ◽  
Ovx Rats ◽  
Voltage Dependent ◽  
Female Wistar Rats

The study was designed to investigate the effect of estradiol on the excitatory effect of oxytocin (OT) on colon motility. Female Wistar rats were used, and some of them were ovariectomized (OVX) and treated with vehicle or estradiol (E2). A plastic balloon made of condom was inserted into colon to monitor the change of colonic pressure in vivo. Longitudinal muscle strips of distal colon were prepared to monitor the spontaneous contraction of colon in vitro. Expression of OT receptor (OTR) was investigated by Western blot analysis. Expression of OTR mRNA was detected by RT-PCR. Immunohistochemistry was used to locate OTR. In OVX rats, pretreatment of E2 (4–100 μg/kg sc) dose-dependently increased the excitatory effect of OT on colon motility both in vivo and in vitro and increased the expression of OTR and OTR mRNA in colon. Systemic administration of OT excited the colon motility in vivo in rats at perioda of proestrus and estrus but did not influence it at diestrus period, when the concentration of plasma E2 was lowest in the estrous cycle. Pretreatment of atosiban, the specific OTR antagonist, and TTX, the blocker of voltage-dependent sodium channel on nerve fiber, attenuated the excitatory effect of OT on colon motility. OTR was located in myenteric plexus of colon. These results suggested that E2 increased the excitatory effect of OT on colon motility by upregulating the expression of OTR in myenteric plexus.

Distal Colon Motility in Schizophrenic Patients

1980 ◽  
Vol 20 (7) ◽  
pp. 459-464 ◽  
Author(s):  
FUAD LECHIN ◽  
FRANCISCO GÖMEZ ◽  
BERTHA van der DIJS ◽  
ERNESTO LECHIN
Keyword(s):  
Distal Colon ◽  
Colon Motility ◽  
Schizophrenic Patients

Distal colon motility as a predictor of antidepressant response to fenfluramine, imipramine and clomipramine

1983 ◽  
Vol 5 (1) ◽  
pp. 27-35 ◽  
Author(s):  
F. Lechin ◽  
B. Van der Dijs ◽  
F. Gómez ◽  
L. Arocha ◽  
E. Acosta ◽  
...  
Keyword(s):  
Distal Colon ◽  
Colon Motility ◽  
Antidepressant Response

Distal colon motility and clinical parameters in depression

1983 ◽  
Vol 5 (1) ◽  
pp. 19-26 ◽  
Author(s):  
F. Lechin ◽  
B. Van der Dijs ◽  
E. Acosta ◽  
F. Gómez ◽  
E. Lechin ◽  
...  
Keyword(s):  
Distal Colon ◽  
Clinical Parameters ◽  
Colon Motility

Nitrergic-purinergic interactions in rat distal colon motility

2004 ◽  
Vol 16 (1) ◽  
pp. 81-98 ◽  
Author(s):  
K. Van Crombruggen ◽  
R. A. Lefebvre
Keyword(s):  
Distal Colon ◽  
Colon Motility ◽  
Rat Distal Colon
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