Hemolysis, elevated liver enzymes, and low platelets in pregnancy (HELLP syndrome)

1991 ◽  
Vol 36 (11) ◽  
pp. 1649-1652 ◽  
Author(s):  
Beth Schorr-Lesnick ◽  
Brad Dworkin ◽  
William S. Rosenthal
Keyword(s):  
Hellp Syndrome ◽  
Liver Enzymes ◽  
Elevated Liver Enzymes ◽  
In Pregnancy

Acute Severe Pancreatitis in Pregnancy Masquerading as Partial Hemolysis Elevated Liver enzymes Low Platelet (HELLP) Syndrome

2015 ◽  
Vol 2 (2) ◽  
Author(s):  
Talat Dabaghi ◽  
Mona Shariati ◽  
Masoumeh Dadashaliha ◽  
Mousa Talebi Bakhshayesh ◽  
Ali Zargar
Keyword(s):  
Hellp Syndrome ◽  
Liver Enzymes ◽  
Acute Severe Pancreatitis ◽  
Severe Pancreatitis ◽  
Elevated Liver Enzymes ◽  
In Pregnancy

scholarly journals A study of maternal and perinatal outcome in cases of HELLP and partial HELLP syndrome

2017 ◽  
Vol 6 (12) ◽  
pp. 5491 ◽  
Author(s):  
Kanchan Durugkar
Keyword(s):  
Prospective Study ◽  
Hellp Syndrome ◽  
Perinatal Outcome ◽  
Liver Enzymes ◽  
Severe Preeclampsia ◽  
Perinatal Morbidity ◽  
Elevated Liver Enzymes ◽  
Low Platelet Count ◽  
Laboratory Investigations ◽  
In Pregnancy

Background: The HELLP syndrome is a serious complication in pregnancy characterized by haemolysis, elevated liver enzymes and low platelet count occurring in 0.5 to 0.9% of all pregnancies and in 10-20% of cases with severe preeclampsia. The objective of the present prospective study is to study on incidence, diagnosis, and variable presentations of HELLP syndrome in preeclampsia to analyse the severity and complications, as it is associated with maternal, perinatal morbidity and mortality. HELLP syndrome is difficult to diagnose when it presents with atypical clinical features.Methods: In the prospective study of 300 admitted cases with more than 20 weeks of gestation, were having preeclampsia. The selected cases were analyzed clinically with relevant history, clinical data and detailed laboratory investigations made for better analyses of complications and outcome in HELLP syndrome.Results: Under further clinical diagnosis of 300 cases of preeclampsia, 34 cases (11.33%) were of HELLP Syndrome and 44 (14.66%) cases were of partial HELLP syndrome. The present study shows 2.9% maternal mortality in HELLP and 4.5% in partial HELLP syndrome. Perinatal mortality was 17.6% with HELLP and 25% with partial HELLP.Conclusions: The diagnosis of HELLP syndrome has been made as a severe variant and complication of severe preeclampsia and eclampsia. It needs early diagnosis, timely intervention to arrest further progress and complications like multi organ dysfunction, renal failure, DIC, abruption etc and to improve maternal and perinatal outcome.

scholarly journals Appendicitis in pregnancy mimicking haemolysis, elevated liver enzymes and low platelets syndrome

2011 ◽  
Vol 4 (1) ◽  
pp. 35-36
Author(s):  
Pooja Sikka ◽  
Neelam Aggarwal ◽  
Seema Chopra ◽  
Vanita Suri
Keyword(s):  
Abdominal Pain ◽  
Hellp Syndrome ◽  
Liver Enzymes ◽  
High Index ◽  
Biochemical Evidence ◽  
Elevated Liver Enzymes ◽  
High Index Of Suspicion ◽  
In Pregnancy

We report a patient with pregnancy at term in whom appendicitis mimicked haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome. A high index of suspicion of appendicitis should be kept in patients with abdominal pain and biochemical evidence of HELLP.

scholarly journals Babesiosis in Pregnancy: An Imitator of HELLP Syndrome

2019 ◽  
Vol 09 (02) ◽  
pp. e147-e152 ◽  
Author(s):  
Raminder Khangura ◽  
Nayo Williams ◽  
Shontreal Cooper ◽  
Anne- Marie Prabulos
Keyword(s):  
Hellp Syndrome ◽  
Clinical Presentation ◽  
Liver Enzymes ◽  
Neonatal Morbidity ◽  
Pregnancy Complication ◽  
Morbidity And Mortality ◽  
Fetal Outcomes ◽  
Laboratory Findings ◽  
Elevated Liver Enzymes ◽  
In Pregnancy

AbstractHELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) is a serious pregnancy complication that can cause significant maternal and neonatal morbidity and mortality. There are several conditions that may occur in pregnancy that may imitate the laboratory findings and clinical presentation of HELLP syndrome. Babesiosis is a parasitic imitator of HELLP syndrome that can be spread by the tick, transfusions, or congenitally. Recognition and treatment of this condition is important to optimize maternal and fetal outcomes.

scholarly journals Haemolysis, elevated liver enzymes and low platelets: Diagnosis and management in critical care

2021 ◽  
pp. 175114372110254
Author(s):  
Evangelia Poimenidi ◽  
Yavor Metodiev ◽  
Natasha Nicole Archer ◽  
Richard Jackson ◽  
Mansoor Nawaz Bangash ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Critical Care ◽  
Liver Failure ◽  
Hellp Syndrome ◽  
Seizure Control ◽  
Liver Enzymes ◽  
Kidney Injury ◽  
Definitive Treatment ◽  
Multisystem Disease ◽  
Elevated Liver Enzymes

A thirty-year-old pregnant woman was admitted to hospital with headache and gastrointestinal discomfort. She developed peripheral oedema and had an emergency caesarean section following an episode of tonic-clonic seizures. Her delivery was further complicated by postpartum haemorrhage and she was admitted to the Intensive Care Unit (ICU) for further resuscitation and seizure control which required infusions of magnesium and multiple anticonvulsants. Despite haemodynamic optimisation she developed an acute kidney injury with evidence of liver damage, thrombocytopenia and haemolysis. Haemolysis, Elevated Liver enzymes and Low Platelets (HELLP) syndrome, a multisystem disease of advanced pregnancy which overlaps with pre-eclampsia, was diagnosed. HELLP syndrome is associated with a range of complications which may require critical care support, including placental abruption and foetal loss, acute kidney injury, microangiopathic haemolytic anaemia, acute liver failure and liver capsule rupture. Definitive treatment of HELLP is delivery of the fetus and in its most severe forms requires admission to the ICU for multiorgan support. Therapeutic strategies in ICU are mainly supportive and include blood pressure control, meticulous fluid balance and possibly escalation to renal replacement therapy, mechanical ventilation, neuroprotection, seizure control, and management of liver failure-related complications. Multidisciplinary input is essential for optimal treatment.

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