Intestinal motility in irritable bowel syndrome: Is IBS a motility disorder?

1993 ◽  
Vol 38 (10) ◽  
pp. 1761-1772 ◽  
Author(s):  
Daniel P. McKee ◽  
Eamonn M. M. Quigley
Keyword(s):  
Irritable Bowel Syndrome ◽  
Intestinal Motility ◽  
Motility Disorder ◽  
Irritable Bowel

scholarly journals Evaluation of Small Intestinal Motility in a Rat Model of Irritable Bowel Syndrome

2021 ◽  
Author(s):  
Masamichi Sato ◽  
Takahiro Kudo ◽  
Nobuyasu Arai ◽  
Reiko Kyodo ◽  
Kenji Hosoi ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Small Intestine ◽  
Real Time ◽  
Rat Model ◽  
Intestinal Motility ◽  
Restraint Stress ◽  
Rat Models ◽  
Small Intestinal Motility ◽  
Small Intestinal ◽  
Irritable Bowel

Abstract Background: The correlation between small intestinal motility alteration and irritable bowel syndrome (IBS) is not well evaluated. Aims: To assess the small intestinal and colonic transits in an IBS rat model with restraint stress and determine the role of small intestinal motility in the IBS pathophysiology.Methods: Restraint stress was utilized to make adolescent IBS rat models that were evaluated for clinical symptoms, including stool frequency and diarrhea. The small intestinal motility and transit rate were also evaluated. The amounts of mRNA encoding corticotropin-releasing hormone, mast cell, and serotonin (5-Hydroxytryptamine; 5-HT) receptor 3a were quantified using real-time polymerase chain reaction (PCR); the 5-HT expression was evaluated using immunostaining.Results: Restraint stress significantly increased the number of fecal pellet outputs, stool water content, and small intestinal motility in the IBS rat models. There was no difference in real-time PCR results, but immunostaining analysis revealed that 5-HT expression in the small intestine was significantly increased in the IBS rat models.Conclusions: In the adolescent rat model of IBS with restraint stress, we observed an increase in small intestinal and colonic motility. In the small intestine, enhanced 5-HT secretion in the distal portion may be involved in increasing the small intestinal motility.

Tu1446 Intestinal Motility Patterns and Bacterial Overgrowth in Idiopathic and Post-Infectious Irritable Bowel Syndrome (IBS)

2012 ◽  
Vol 142 (5) ◽  
pp. S-835
Author(s):  
Andrew W. Dupont ◽  
Zhi-Dong Jiang ◽  
Stephen A. Harold ◽  
Ned Snyder ◽  
Greg Galler ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Intestinal Motility ◽  
Bacterial Overgrowth ◽  
Irritable Bowel ◽  
Post Infectious

Irritable bowel syndrome and its treatment

1983 ◽  
Vol 21 (10) ◽  
pp. 37-39
Keyword(s):  
General Practice ◽  
Irritable Bowel Syndrome ◽  
Adult Population ◽  
Motility Disorder ◽  
Normal Adult ◽  
Irritable Bowel ◽  
A Minor

The irritable bowel syndrome (IBS) is a motility disorder of the gut. Some of its symptoms affect more than 10% of the normal adult population,1 but most people accept these symptoms as a minor nuisance. Only those with severe, persistent and recurrent symptoms, and those who worry about their symptoms, consult a doctor and become ‘patients’ with a ‘disease’. Patients with IBS, about 30% of whom are women under 40, are often seen in general practice and constitute up to half of the referrals to gastroenterological outpatients. Treatment has much to offer but is often unsatisfactory.

The Role of Dietary Approach in Irritable Bowel Syndrome

2019 ◽  
Vol 26 (19) ◽  
pp. 3512-3520 ◽  
Author(s):  
Piero Portincasa ◽  
Antony Lembo ◽  
Ornella de Bari ◽  
Domenica M. Di Palo ◽  
Anna Maggio ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Gastrointestinal Tract ◽  
Intestinal Microbiota ◽  
Intestinal Motility ◽  
Gastrointestinal Diseases ◽  
Functional Disorder ◽  
First Line ◽  
Dietary Education ◽  
Irritable Bowel

Irritable bowel syndrome (IBS) is a chronic functional disorder of the gastrointestinal tract and is one of the most frequent gastrointestinal diseases. In IBS multiple pathophysiological mechanisms including alterations in intestinal motility, permeability, nutrient absorption, and intestinal microbiota have been implicated. Foods are commonly reported by patients to be a trigger of symptoms and therefore are likely involved in the generation of symptoms in IBS. Among all possible therapeutic options, a first-line approach to IBS is dietary education and identification of foods potentially responsible for the onset or worsening of symptoms. Dietary approaches include reduction of gas-producing foods (i.e. fermentable oligo-, di-, and monosaccharides and polyols (FODMAPs)), lactose and gluten. Further studies are required to link the ultimate role of diets in different IBS subtypes.

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