Soluble and bound acid protease activity of myelin from bovine cerebral white matter and spinal cord

1988 ◽  
Vol 13 (5) ◽  
pp. 409-416 ◽  
Author(s):  
Hans H. Berlet ◽  
Heike Ilzenh�fer ◽  
Martin Kaefer
Keyword(s):  
Spinal Cord ◽  
White Matter ◽  
Protease Activity ◽  
Acid Protease ◽  
Cerebral White Matter

scholarly journals Spinal cord injury induces widespread chronic changes in cerebral white matter

2017 ◽  
Author(s):  
Tero Ilvesmäki ◽  
Eerika Koskinen ◽  
Antti Brander ◽  
Teemu Luoto ◽  
Juha Öhman ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
White Matter ◽  
Cerebral White Matter ◽  
Cord Injury

scholarly journals ALLERGIC ENCEPHALOMYELITIS IN MONKEYS IN RESPONSE TO INJECTION OF NORMAL MONKEY NERVOUS TISSUE

1947 ◽  
Vol 85 (1) ◽  
pp. 131-140 ◽  
Author(s):  
Isabel M. Morgan
Keyword(s):  
Spinal Cord ◽  
White Matter ◽  
Peripheral Nerve ◽  
Nervous Tissue ◽  
Acute Disseminated Encephalomyelitis ◽  
Cerebral White Matter ◽  
Allergic Encephalomyelitis ◽  
Central Nervous Tissue ◽  
Normal Monkey ◽  
Cortical Gray Matter

By subcutaneous injection of central nervous tissue emulsified with adjuvants according to Freund's technique it has been possible to induce in the majority of monkeys an acute disseminated encephalomyelitis which is interpreted as an isoimmunization to CNS tissue. Positive reactions occurred only in response to CNS tissue containing white matter; i.e., cerebral white matter, spinal cord (whether normal or poliomyelitis-infected), and cortical "gray" matter (with an estimated 10 per cent contamination with white matter). No reaction occurred when peripheral nerve or kidney suspension or saline alone was injected with adjuvants. The perivascular and extravascular infiltration induced was confined to the CNS.

Acid protease activity in spinal cord and muscle in wobbler mouse

1982 ◽  
Vol 56 (2-3) ◽  
pp. 141-145 ◽  
Author(s):  
Ewa Chelmicka-Schorr ◽  
Michael Sportiello ◽  
Jack P. Antel ◽  
Barry G.W. Arnason
Keyword(s):  
Spinal Cord ◽  
Protease Activity ◽  
Acid Protease ◽  
Wobbler Mouse

scholarly journals Simultaneous new onset of neuromyelitis optica spectrum disorder in identical twins

2021 ◽  
Vol 3 (2) ◽  
pp. e000174
Author(s):  
Ivo Bekavac ◽  
Matea Matejic ◽  
Riley J Woods ◽  
John I Halloran
Keyword(s):  
Spinal Cord ◽  
White Matter ◽  
Neuromyelitis Optica ◽  
Cervical Spinal Cord ◽  
Identical Twins ◽  
Spectrum Disorder ◽  
Cerebral White Matter ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Csf Analysis ◽  
The Brain

ObjectiveTo present a case of two identical twins presenting concurrently with symptoms and subsequent initial diagnosis of neuromyelitis optica spectrum disorder (NMOSD).MethodsClinical, laboratory and MRI findings for both twins were reviewed and presented here.ResultsTwin A presented with right eye pain and subsequent blurred vision in right eye. MRI of the brain and spine demonstrated pre-chiasmal right optic nerve enhancement and T2 hyperintense lesions in the spinal cord at T7 and T9 levels. Cerebrospinal fluid (CSF) analysis was remarkable for NMO/aquaporin-4 (AQP4) fluorescence-activated cell sorting (FACS) titre of 1:32 and a serum NMO/AQP4-IgG positive titre of 1:10 000. Twin B presented with diplopia. MRI of the brain and spine demonstrated T2 hyperintense lesions in the periventricular cerebral white matter, in the periaqueductal white matter of the pons, in the midbrain and the cervical spinal cord. Neurological examination findings revealed incomplete right trochlear palsy, rotatory nystagmus, an incomplete left internuclear ophthalmoplegia and hyper-reflexia. CSF analysis was remarkable for NMO/AQP4 FACS titre of 1:256 and a serum NMO-IgG positive titre of 1:10 000. Both twins responded well to intravenous steroid therapy. There was no adverse environmental exposure present.ConclusionWe present an interesting and rare case of identical twins presenting concurrently and for the first time with NMOSD.

scholarly journals Leucoencephalopathy with brain stem and spinal cord involvement and lactate elevation: a novel mutation in the DARS2 gene

2019 ◽  
Vol 12 (1) ◽  
pp. bcr-2018-227755 ◽  
Author(s):  
Anudeep Yelam ◽  
Elanagan Nagarajan ◽  
Miguel Chuquilin ◽  
Raghav Govindarajan
Keyword(s):  
Spinal Cord ◽  
White Matter ◽  
Brain Stem ◽  
Autosomal Recessive ◽  
Novel Mutation ◽  
Trna Synthetase ◽  
Dorsal Column ◽  
Clinical Findings ◽  
Cerebral White Matter ◽  
Spinal Cord Involvement

Leucoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL) is a very rare autosomal recessive, slowly progressive neurological disorder characterised by distinctive clinical findings including cerebellar, pyramidal and dorsal column dysfunction. This is caused by a mutation in the DARS2 gene, which encodes mitochondrial aspartyl-tRNA synthetase. MRI shows distinctive abnormalities in the cerebral white matter and specific brain stem and spinal cord tracts. Here, we present a case of LBSL, with a novel c.1192-2A>G mutation.

Cerebral White Matter Atrophy and Cognitive Dysfunction Following TBI

2007 ◽  
Author(s):  
Tracy D. Vannorsdall ◽  
Vani Rao ◽  
David J. Schretlen
Keyword(s):  
White Matter ◽  
Cognitive Dysfunction ◽  
Cerebral White Matter
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