Vasopressin and isoproterenol activate adenylate cyclase in the guinea pig inner ear

1979 ◽  
Vol 222 (4) ◽  
pp. 275-283 ◽  
Author(s):  
Hans -Peter Zenner ◽  
Birgit Zenner
Keyword(s):  
Adenylate Cyclase ◽  
Guinea Pig ◽  
Inner Ear

Hair Cell Damage in the Inner Ear of the Guinea Pig Due to Noise in a Workshop

1987 ◽  
Vol 103 (5) ◽  
pp. 204-211 ◽  
Author(s):  
B. Erlandsson ◽  
H. Hakanson ◽  
A. Ivarsson ◽  
P. Nilsson ◽  
J. Wersall
Keyword(s):  
Guinea Pig ◽  
Hair Cell ◽  
Inner Ear ◽  
Cell Damage ◽  
Hair Cell Damage

X-ray microanalysis of inner ear fluids in the embryonic and newborn guinea pig

1982 ◽  
Vol 234 (2) ◽  
pp. 125-130 ◽  
Author(s):  
Matti Anniko ◽  
Aron Sobin ◽  
Romuald Wr�blewski
Keyword(s):  
Guinea Pig ◽  
Inner Ear ◽  
X Ray ◽  
Inner Ear Fluids

The effect of diazepam on adenosine uptake and adenosine-stimuiated adenylate cyclase in guinea-pig brain

1982 ◽  
Vol 60 (3) ◽  
pp. 302-307 ◽  
Author(s):  
M. J. York ◽  
L. P. Davies
Keyword(s):  
Adenylate Cyclase ◽  
Guinea Pig ◽  
Adenosine Deaminase ◽  
Small Component ◽  
Extracellular Adenosine ◽  
Pig Brain ◽  
Adenosine Uptake ◽  
Adenosine Antagonist ◽  
Guinea Pig Brain ◽  
Stimulation Of

We have used the adenosine-stimulated adenylate cyclase of guinea-pig brain to examine the potency of diazepam as an adenosine uptake inhibitor. Diazepam at concentrations in the range 10–500 μM stimulates the production of cAMP in incubated slices of guinea-pig cerebral cortex, with maximal fivefold stimulations over basal levels by 200 μM diazepam. The increases can be largely (but not completely) blocked by the adenosine antagonist theophylline or by addition of excess adenosine deaminase to the system. It appears that the stimulation of cAMP production is due to a blockade of adenosine uptake which results in an increase in extracellular adenosine and concomitant activation of the adenosine receptor coupled to adenylate cyclase. Since the cAMP response to standard adenosine uptake blockers (dipyridamole, dilazep) can be completely blocked by theophylline or adenosine deaminase, a small component of the diazepam response cannot be explained by an adenosine effect. The concentration of diazepam at which the first significant cAMP increase occurs is 10 μM or slightly lower. This is significantly higher than the concentration of diazepam needed to saturate the pharmacologically characterized central nervous system receptors for benzodiazepines.

Molecular cloning of theCochgene of guinea pig inner ear and its expression analysis in cultured fibrocytes of the spiral ligament

2010 ◽  
Vol 130 (8) ◽  
pp. 868-880
Author(s):  
Lishu Li ◽  
Tetsuo Ikezono ◽  
Kuwon Sekine ◽  
Susumu Shindo ◽  
Tomohiro Matsumura ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Inner Ear ◽  
Molecular Cloning ◽  
Expression Analysis ◽  
Spiral Ligament

Role of capillary pericytes and precapillary arterioles in the vascular mechanism of betahistine in a guinea pig inner ear model

Life Sciences ◽  
2017 ◽  
Vol 187 ◽  
pp. 17-21 ◽  
Author(s):  
Mattis Bertlich ◽  
Friedrich Ihler ◽  
Bernhard G. Weiss ◽  
Saskia Freytag ◽  
Michael Strupp ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Inner Ear

Erythropoietin and erythropoietin receptor expression in the guinea pig inner ear

2005 ◽  
Vol 203 (1-2) ◽  
pp. 21-27 ◽  
Author(s):  
Per Cayé-Thomasen ◽  
Niels Wagner ◽  
Birgitte Lidegaard Frederiksen ◽  
Korhan Asal ◽  
Jens Thomsen
Keyword(s):  
Guinea Pig ◽  
Inner Ear ◽  
Erythropoietin Receptor ◽  
Receptor Expression
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