Reduced inhibitory effects of clonidine and neuropeptide Y on3H-noradrenaline release from synaptosomes of the medulla oblongata of the spontaneously hypertensive rat

1989 ◽  
Vol 76 (3) ◽  
pp. 181-189 ◽  
Author(s):  
M. Martire ◽  
K. Fuxe ◽  
G. Pistritto ◽  
P. Preziosi ◽  
L. F. Agnati
Keyword(s):  
Neuropeptide Y ◽  
Medulla Oblongata ◽  
Noradrenaline Release ◽  
Spontaneously Hypertensive Rat ◽  
Inhibitory Effects ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat

scholarly journals Ultrastructural Correlates of Enhanced Norepinephrine and Neuropeptide Y Cotransmission in the Spontaneously Hypertensive Rat Brain

ASN NEURO ◽  
2015 ◽  
Vol 7 (5) ◽  
pp. 175909141561011 ◽  
Author(s):  
Ioannis Kourtesis ◽  
Sergey Kasparov ◽  
Paul Verkade ◽  
Anja G. Teschemacher
Keyword(s):  
Neuropeptide Y ◽  
Rat Brain ◽  
Spontaneously Hypertensive Rat ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat

Increased Presynaptic α-Adrenoceptor-Mediated Regulation of Noradrenaline Release in the Isolated Perfused Kidney of Spontaneously Hypertensive Rats

1982 ◽  
Vol 63 (s8) ◽  
pp. 309s-311s ◽  
Author(s):  
R. D. Ekas ◽  
M. L. Steenberg ◽  
M. F. Lokhandwala
Keyword(s):  
Nerve Stimulation ◽  
Noradrenaline Release ◽  
Spontaneously Hypertensive Rats ◽  
Spontaneously Hypertensive Rat ◽  
Hypertensive Rats ◽  
Isolated Perfused Kidney ◽  
Spontaneously Hypertensive ◽  
Wistar Kyoto Rats ◽  
Hypertensive Rat ◽  
Wistar Kyoto

1. Release of [3H]noradrenaline during peri-arterial nerve stimulation and its inhibition by the presynaptic α-adrenoceptor mechanism were studied in the isolated perfused kidney from spontaneously hypertensive and Wistar-Kyoto rats. 2. A frequency related vasoconstriction as well as [3H]noradrenaline release were observed over the stimulating range of 0.25-32 Hz in both the Wistar-Kyoto and spontaneously hypertensive rats. The spontaneously hypertensive rat kidneys exhibited both an increased vasoconstrictor response and a greater [3H]noradrenaline release when compared with the Wistar-Kyoto rat kidneys. 3. Presynaptic inhibition of [3H]noradrenaline release was evaluated at 2 Hz by using the α-adrenoceptor agonist, tramazoline. Increasing concentrations of tramazoline from 2 × 10−9 mol/l to 2 × 10−7 mol/l caused a dose-dependent decrease in the stimulus-induced release of [3H]noradrenaline in spontaneously hypertensive rats but not in Wistar-Kyoto rats. Only 2 × 10−7 mol/l tramazoline had an inhibitory effect in the Wistar-Kyoto rats. 4. These data indicate that noradrenaline release during sympathetic nerve stimulation is greater in the spontaneously hypertensive rat. The supersensitivity of presynaptic α-adrenoceptors observed in spontaneously hypertensive rats may be a consequence of the greater noradrenaline release present in these animals.

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