Intratypic antigenic heterogeneity of Coxsackie B viruses

1963 ◽  
Vol 12 (1) ◽  
pp. 29-41 ◽  
Author(s):  
Reinhard Wigand ◽  
Albert B. Sabin
Keyword(s):  
Coxsackie B Viruses ◽  
Antigenic Heterogeneity ◽  
Coxsackie B

Coxsackie B viruses and autoimmune diabetes

1982 ◽  
Vol 101 (4) ◽  
pp. 647-648 ◽  
Author(s):  
C.S. Bartsocas ◽  
C.J. Papadatos ◽  
M. Lab ◽  
N. Spyrou ◽  
B. Krikelis ◽  
...  
Keyword(s):  
Autoimmune Diabetes ◽  
Coxsackie B Viruses ◽  
Coxsackie B

scholarly journals RNA Recombination Plays a Major Role in Genomic Change during Circulation of Coxsackie B Viruses

2004 ◽  
Vol 78 (6) ◽  
pp. 2948-2955 ◽  
Author(s):  
M. Steven Oberste ◽  
Silvia Peñaranda ◽  
Mark A. Pallansch
Keyword(s):  
Phylogenetic Trees ◽  
Clinical Isolates ◽  
Human Enterovirus ◽  
Rna Recombination ◽  
Genomic Change ◽  
Genome Region ◽  
Nontranslated Region ◽  
Frequent Event ◽  
Coxsackie B Viruses ◽  
Coxsackie B

ABSTRACT RNA recombination has been shown to occur during circulation of enteroviruses, but most studies have focused on poliovirus. To examine the role of recombination in the evolution of the coxsackie B viruses (CVB), we determined the partial sequences of four genomic intervals for multiple clinical isolates of each of the six CVB serotypes isolated from 1970 to 1996. The regions sequenced were the 5′-nontranslated region (5′-NTR) (350 nucleotides [nt]), capsid (VP4-VP2, 416 nt, and VP1, ∼320 nt), and polymerase (3D, 491 nt). Phylogenetic trees were constructed for each genome region, using the clinical isolate sequences and those of the prototype strains of all 65 enterovirus serotypes. The partial VP1 sequences of each CVB serotype were monophyletic with respect to serotype, as were the VP4-VP2 sequences, in agreement with previously published studies. In some cases, however, incongruent tree topologies suggested that intraserotypic recombination had occurred between the sequenced portions of VP2 and VP1. Outside the capsid region, however, isolates of the same serotype were not monophyletic, indicating that recombination had occurred between the 5′-NTR and capsid, the capsid and 3D, or both. Almost all clinical isolates were recombinant relative to the prototype strain of the same serotype. All of the recombination partners appear to be members of human enterovirus species B. These results suggest that recombination is a frequent event during enterovirus evolution but that there are genetic restrictions that may influence recombinational compatibility.

Association between group G chromosomes, especially chromosome G21, and susceptibility of human cells to coxsackie B viruses

1978 ◽  
Vol 86 (5) ◽  
pp. 1493-1496
Author(s):  
Ya. E. Khesin ◽  
A. M. Amchenkova ◽  
N. E. Gulevich ◽  
A. N. Narovlyanskii
Keyword(s):  
Human Cells ◽  
Coxsackie B Viruses ◽  
Coxsackie B

Echoviruses and Coxsackie B Viruses That Use Human Decay‐Accelerating Factor (DAF) as a Receptor Do Not Bind the Rodent Analogues of DAF

2000 ◽  
Vol 181 (1) ◽  
pp. 340-343 ◽  
Author(s):  
O. Brad Spiller ◽  
Ian G. Goodfellow ◽  
David J. Evans ◽  
Jeffrey W. Almond ◽  
B. Paul Morgan
Keyword(s):  
Decay Accelerating Factor ◽  
Coxsackie B Viruses ◽  
Coxsackie B

Coxsackie B viruses use multiple receptors to infect human cardiac cells

2004 ◽  
Vol 74 (2) ◽  
pp. 291-299 ◽  
Author(s):  
George Orthopoulos ◽  
Kathy Triantafilou ◽  
Martha Triantafilou
Keyword(s):  
Cardiac Cells ◽  
Multiple Receptors ◽  
Coxsackie B Viruses ◽  
Coxsackie B

Use of synthetic oligodeoxyribonucleotides for type-specific identification of coxsackie B viruses

1989 ◽  
Vol 3 (2) ◽  
pp. 103-108 ◽  
Author(s):  
Marianne Alksnis ◽  
Michael Lindberg ◽  
Per Stålhandske ◽  
Hans Hultberg ◽  
Ulf Pettersson
Keyword(s):  
Specific Identification ◽  
Coxsackie B Viruses ◽  
Coxsackie B

scholarly journals MDA5 and MAVS Mediate Type I Interferon Responses to Coxsackie B Virus

2009 ◽  
Vol 84 (1) ◽  
pp. 254-260 ◽  
Author(s):  
Jennifer P. Wang ◽  
Anna Cerny ◽  
Damon R. Asher ◽  
Evelyn A. Kurt-Jones ◽  
Roderick T. Bronson ◽  
...  
Keyword(s):  
Type I Interferon ◽  
Histopathological Examination ◽  
Hepatic Necrosis ◽  
Type I ◽  
Innate Immune Responses ◽  
Inflammatory Cytokine Production ◽  
B Virus ◽  
Coxsackie B Viruses ◽  
Interferon Responses ◽  
Coxsackie B

ABSTRACT Coxsackie B viruses (CVB) are enteroviruses that have been associated with a variety of human diseases, including myocarditis. In the present study, we found that MDA5 and its adaptor molecule MAVS are critical for type I interferon responses to CVB, since the absence of either MAVS or MDA5 leads to deficient type I interferon production and early mortality in mice infected with CVB. Pancreatic and hepatic necrosis were observed on histopathological examination of MAVS and MDA5 knockout mice infected with CVB. Inflammatory cytokine production in response to systemic CVB infection was independent of MAVS. Surprisingly, virus titers were not elevated in MAVS-deficient mice, despite significant reductions in type I interferon levels. These data highlight the importance of type I interferon in host defense and provide insight on the mechanisms of innate immune responses following coxsackievirus infection.

scholarly journals Splenomegaly in acute infections due to group A streptococci and viruses

1992 ◽  
Vol 109 (2) ◽  
pp. 199-209 ◽  
Author(s):  
P. M. Higgins
Keyword(s):  
Mononuclear Cells ◽  
Streptococcal Infection ◽  
Group A Streptococci ◽  
Upper Respiratory Tract ◽  
Cervical Lymphadenitis ◽  
Acute Infections ◽  
Group A ◽  
Coxsackie B Viruses ◽  
Upper Respiratory ◽  
Coxsackie B

SUMMARYOver a period of 9 years in general practice temporary enlargement of the spleen was found in 29 episodes of pharyngitis or tonsillitis, in 2 episodes of acute upper respiratory tract infection other than pharyngitis and in 6 episodes of acute cervical lymphadenitis. In five patients more than one episode of illness associated with splenomegaly was recorded.In 26 of the 37 episodes a possible aetiology was identified. Evidence only of infection with group A streptococci was found in 14 episodes, adenoviruses or coxsackie B viruses were isolated alone in 4 episodes and in 4 episodes the only finding was the presence in the blood of more than occasional atypical mononuclear cells; in 4 episodes there was evidence of both streptococcal and viral infection. Episodes with evidence of streptococcal infection only tended to be of shorter duration and to be more evenly distributed over the year than were episodes without such evidence. Temporary splenomegaly was noted also in two children with varicella (one of whom also had streptococcal infection) and in an adult with probable rubella.

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