Effect of destruction of central noradrenergic and serotonergic nerve terminals by systemic neurotoxins on the long-term effects of antidepressants on?-adrenoceptors and 5-HT2 binding sites in the rat cerebral cortex

1984 ◽  
Vol 59 (1) ◽  
pp. 9-23 ◽  
Author(s):  
H. Hall ◽  
S. B. Ross ◽  
Maria S�llemark
Keyword(s):  
Cerebral Cortex ◽  
Binding Sites ◽  
Rat Cerebral Cortex ◽  
Nerve Terminals ◽  
Long Term Effects

Hyperthermia‐induced seizures produce long‐term effects on the functionality of adenosine A 1 receptor in rat cerebral cortex

2020 ◽  
Vol 80 (1) ◽  
pp. 1-12
Author(s):  
María Crespo ◽  
David Agustín León‐Navarro ◽  
María Ángeles Ruíz ◽  
Mairena Martín
Keyword(s):  
Cerebral Cortex ◽  
Rat Cerebral Cortex ◽  
Long Term Effects

3-[(±)-2-Carboxypiperazin-4-yl]propyl-1-Phosphonic Acid Recognizes Two N-Methyl-D-Aspartate Binding Sites in Rat Cerebral Cortex Membranes

1992 ◽  
Vol 59 (5) ◽  
pp. 1850-1855 ◽  
Author(s):  
Frank Th. M. Amsterdam ◽  
Alessandra Giberti ◽  
Manolo Mugnaini ◽  
Emiliangelo Ratti
Keyword(s):  
Cerebral Cortex ◽  
Phosphonic Acid ◽  
Binding Sites ◽  
Rat Cerebral Cortex

Regulation of g-protein mRNA abundancy and cAMP accumulation after long-term opioid incubation in primary cultures of astroglia from the rat cerebral cortex

1992 ◽  
Vol 16 (3-4) ◽  
pp. 345-352 ◽  
Author(s):  
Peter S. Eriksson ◽  
Björn Carlsson ◽  
Olle G.P. Isaksson ◽  
Elisabeth Hansson ◽  
Lars Rönnbäck
Keyword(s):  
Cerebral Cortex ◽  
G Protein ◽  
Primary Cultures ◽  
Rat Cerebral Cortex ◽  
Camp Accumulation

scholarly journals Differentiation of [3 H]phencyclidine and ( + )-[3 H]SKF-10,047 binding sites in rat cerebral cortex

FEBS Letters ◽  
1985 ◽  
Vol 190 (2) ◽  
pp. 333-336 ◽  
Author(s):  
Mark E. Goldman ◽  
Arthur E. Jacobson ◽  
Kenner C. Rice ◽  
Steven M. Paul
Keyword(s):  
Cerebral Cortex ◽  
Binding Sites ◽  
Rat Cerebral Cortex

Sexual dimorphism in [3H]histamine binding sites of rat cerebral cortex

1991 ◽  
Vol 23 (2) ◽  
pp. 187-193 ◽  
Author(s):  
P. Ghi ◽  
C. Ferretti ◽  
M.L. Lupi ◽  
M. Blengio ◽  
P. Portaleone
Keyword(s):  
Cerebral Cortex ◽  
Sexual Dimorphism ◽  
Binding Sites ◽  
Rat Cerebral Cortex ◽  
Histamine Binding

scholarly journals Solubilization and characterization of high and low affinity pirenzepine binding sites from rat cerebral cortex

1985 ◽  
Vol 85 (3) ◽  
pp. 697-703 ◽  
Author(s):  
Christopher P. Berrie ◽  
Nigel J.M. Birdsall ◽  
Edward C. Hulme ◽  
Mary Keen ◽  
Jane M. Stockton
Keyword(s):  
Cerebral Cortex ◽  
Binding Sites ◽  
Rat Cerebral Cortex

scholarly journals Acute action of DSP-4 on central norepinephrine axons: biochemical and immunohistochemical evidence for differential effects.

1989 ◽  
Vol 37 (9) ◽  
pp. 1435-1442 ◽  
Author(s):  
R Grzanna ◽  
U Berger ◽  
J M Fritschy ◽  
M Geffard
Keyword(s):  
Cerebral Cortex ◽  
High Performance ◽  
Direct Evidence ◽  
Selective Vulnerability ◽  
Brain Regions ◽  
Acute Effects ◽  
Long Term Effects ◽  
Immunohistochemical Evidence ◽  
Immunohistochemical Studies

Previous immunohistochemical studies of the long-term effects of the noradrenergic neurotoxin DSP-4 have demonstrated a remarkably selective vulnerability of norepinephrine (NE) axons of the locus coeruleus (LC). NE axons originating in non-LC NE neurons appear to be largely resistant to the neurotoxic action of DSP-4. We conducted this study to evaluate the acute effects of DSP-4 on NE axons in four different brain regions: cerebral cortex, cerebellum, ventral forebrain, and hypothalamus. NE levels were determined by high-performance liquid chromatography (HPLC) 6 and 24 hr and 14 days after DSP-4 administration. NE axons in these brain regions were visualized in brain sections at 6 and 24 hr after drug treatment, using a specific antiserum to NE. HPLC assays revealed profound reductions of NE levels in cerebral cortex and cerebellum, but only minor decreases in ventral forebrain and hypothalamus. NE immunohistochemistry showed dramatic differences in the acute effects of DSP-4 on NE axon staining: nearly complete loss of staining in cortex and cerebellum, in contrast to an almost unchanged staining pattern in ventral forebrain and hypothalamus. This study demonstrates that NE immunohistochemistry is a valuable tool to assess the acute effects of DSP-4 on NE axons in different brain regions. The results provide the first direct evidence that NE axons are not uniformly acted on by DSP-4 and suggest that the acute effects of DSP-4 are restricted to LC axons.

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