The pineal gland of the mole (Talpa europaea L.) VII. Activity of hydroxyindole-O-methyltransferase (HIOMT) in the formation of 5-methoxytryptophan, 5-methoxytryptamine, 5-methoxyindole-3-acetic acid, 5-methoxytryptophol and melatonin in the eyes and the pineal gland

1981 ◽  
Vol 51 (3-4) ◽  
pp. 271-282 ◽  
Author(s):  
P. Pévet ◽  
M. G. M. Balemans ◽  
G. F. de Reuver
Keyword(s):  
Acetic Acid ◽  
Pineal Gland ◽  
Talpa Europaea

The pineal gland of the mole (Talpa europaea L.)

1976 ◽  
Vol 165 (3) ◽  
Author(s):  
P. Pevet ◽  
M.T. Juillard ◽  
A.R. Smith ◽  
J. Ari�ns Kappers
Keyword(s):  
Pineal Gland ◽  
Talpa Europaea

scholarly journals Effects of Streptozotocin-Induced Diabetes on the Pineal Gland in the Domestic Pig

2018 ◽  
Vol 19 (10) ◽  
pp. 3077 ◽  
Author(s):  
Bogdan Lewczuk ◽  
Magdalena Prusik ◽  
Natalia Ziółkowska ◽  
Michał Dąbrowski ◽  
Kamila Martniuk ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Pineal Gland ◽  
Vanillylmandelic Acid ◽  
Domestic Pig ◽  
Streptozotocin Induced Diabetes ◽  
Adrenergic Neurotransmission ◽  
Gland Function ◽  
Biochemical Analyses ◽  
In Vitro Treatment

Several observations from experiments in rodents and human patients suggest that diabetes affects pineal gland function, including melatonin secretion; however, the accumulated data are not consistent. The aim of the present study was to determine the effects of streptozotocin-induced diabetes on the pineal gland in the domestic pig, a species widely used as a model in various biomedical studies. The study was performed on 10 juvenile pigs, which were divided into two groups: control and diabetic. Diabetes was evoked by administration of streptozotocin (150 mg/kg of body weight). After six weeks, the animals were euthanized between 12.00 and 14.00, and the pineal glands were removed and divided into two equal parts, which were used for biochemical analyses and for preparation of explants for the superfusion culture. The pineal contents (per 100 μg protein) of serotonin, 5-hydroxyindole acetic acid, 5-hydroxytryptophol, 5-methoxyindole acetic acid, 5-methoxytryptophol, and 5-methoxytryptamine were significantly lower in diabetic pigs than in control pigs. In contrast, the level of N-acetylserotonin was significantly higher in diabetic animals. No significant differences were found in the level of melatonin between control and experimental pigs. The amounts of 3,4-dihydroxyphenylalanine, dopamine, norepinephrine, and 3,4-dihydroxyphenylacetic acid were significantly lower in the pineal glands of diabetic animals. The level of vanillylmandelic acid was higher in diabetic pigs. No differences were observed in the level of basal and NE-stimulated release of N-acetylserotonin or melatonin between the pineal explants prepared from control and experimental animals. In vitro treatment with insulin was ineffective. In conclusion, streptozotocin-induced diabetes affects both indole metabolism and adrenergic neurotransmission in the pig pineal gland.

Relationships between methoxyindoles and hydroxyindoles formed from 5-hydroxytryptamine in rat pineal gland

1982 ◽  
Vol 95 (2) ◽  
pp. 253-256 ◽  
Author(s):  
D. J. Morton ◽  
B. Potgieter
Keyword(s):  
Acetic Acid ◽  
Pineal Gland ◽  
Thin Layer ◽  
Chromatographic Separation ◽  
The Other ◽  
Rat Pineal Gland

5-Hydroxytryptophol, 5-methoxytryptophol, 5-hydroxyindole-3-acetic acid, 5-methoxyindole-3-acetic acid, N-acetylserotonin and N-acetyl-5-methoxytryptamine produced in pineal gland culture from [14C]serotonin were measured after thin-layer chromatographic separation. A correlation between the amounts of hydroxy- and corresponding methoxyindoles was sought. The results showed a correlation between N-acetylserotonin levels and the production of N-acetyl-5-methoxytryptamine, whereas no correlation between the other hydroxy- and methoxyindoles was found.

Day:Night variations of melatonin, 5-hydroxyindole acetic acid, serotonin, serotonin N-acetytransferase, tryptophan, norephinephrine and dopamine in the rabbit pineal gland

Life Sciences ◽  
1984 ◽  
Vol 35 (15) ◽  
pp. 1615-1622 ◽  
Author(s):  
George C. Brainard ◽  
Susan A. Matthews ◽  
Richard W. Steger ◽  
Russel J. Reiter ◽  
Ricardo H. Asch
Keyword(s):  
Acetic Acid ◽  
Pineal Gland
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