Presynaptic effects of gamma-aminobutyric acid on norepinephrine release and uptake in rat pineal gland

1990 ◽  
Vol 82 (2) ◽  
pp. 131-140 ◽  
Author(s):  
R. E. Rosenstein ◽  
H. E. Chuluyan ◽  
D. P. Cardinali
Keyword(s):  
Pineal Gland ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Norepinephrine Release ◽  
Rat Pineal Gland

Presynaptic effects of melatonin on norepinephrine release and uptake in rat pineal gland

1991 ◽  
Vol 10 (4) ◽  
pp. 165-173 ◽  
Author(s):  
Héctor E. Chuluyan ◽  
Ruth E. Rosenstein ◽  
Su Min Chang ◽  
María M. Gálvez ◽  
Daniel P. Cardinali
Keyword(s):  
Pineal Gland ◽  
Norepinephrine Release ◽  
Rat Pineal Gland

Gamma aminobutyric acid uptake, release, and effect on36Cl?-influx in bovine pineal gland

1989 ◽  
Vol 77 (2-3) ◽  
pp. 141-152 ◽  
Author(s):  
Ruth E. Rosenstein ◽  
Claudia Sanjurjo ◽  
D. P. Cardinali
Keyword(s):  
Pineal Gland ◽  
Aminobutyric Acid ◽  
Acid Uptake ◽  
Gamma Aminobutyric Acid ◽  
Bovine Pineal Gland

Norepinephrine Release in the Rat Pineal Gland: The Input from the Biological Clock Measured by In Vivo Microdialysis

2002 ◽  
Vol 66 (2) ◽  
pp. 748-755 ◽  
Author(s):  
W. J. Drijfhout ◽  
A. G. Van Der Linde ◽  
S. E. Kooi ◽  
C. J. Grol ◽  
B. H. C. Westerink
Keyword(s):  
Pineal Gland ◽  
Biological Clock ◽  
In Vivo Microdialysis ◽  
Norepinephrine Release ◽  
Rat Pineal Gland

In vitro effect of neuropeptide Y on melatonin and norepinephrine release in rat pineal gland

1987 ◽  
Vol 7 (3) ◽  
pp. 309-315 ◽  
Author(s):  
Mar�a I. Vacas ◽  
Mar�a I. Keller Sarmiento ◽  
Elba N. Pereyra ◽  
Graciela S. Etchegoyen ◽  
Daniel P. Cardinali
Keyword(s):  
Pineal Gland ◽  
Neuropeptide Y ◽  
Norepinephrine Release ◽  
Vitro Effect ◽  
Rat Pineal Gland

Purification of Antihemophilic Factor (Factor VIII) by Amino Acid Precipitation*

1964 ◽  
Vol 11 (01) ◽  
pp. 064-074 ◽  
Author(s):  
Robert H Wagner ◽  
William D McLester ◽  
Marion Smith ◽  
K. M Brinkhous
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Factor Viii ◽  
Plasma Protein ◽  
Acid Precipitation ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Specific Procedure ◽  
Beta Alanine ◽  
Antihemophilic Factor

Summary1. The use of several amino acids, glycine, alpha-aminobutyric acid, alanine, beta-alanine, and gamma-aminobutyric acid, as plasma protein precipitants is described.2. A specific procedure is detailed for the preparation of canine antihemophilic factor (AHF, Factor VIII) in which glycine, beta-alanine, and gammaaminobutyric acid serve as the protein precipitants.3. Preliminary results are reported for the precipitation of bovine and human AHF with amino acids.

A Simple Method for Preparing Fibrinogen

1966 ◽  
Vol 16 (01/02) ◽  
pp. 198-206 ◽  
Author(s):  
W Straughn ◽  
R. H Wagner
Keyword(s):  
Barium Sulfate ◽  
Caproic Acid ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Human Fibrinogen ◽  
Simple Method ◽  
High Yields ◽  
Marked Stability

SummaryA simple new procedure is reported for the isolation of canine, bovine, porcine, and human fibrinogen. Two molar β-alanine is used to precipitate fibrinogen from barium sulfate adsorbed plasma. The procedure is characterized by dependability and high yields. The material is 95% to 98% clottable protein but still contains impurities such as plasminogen and fibrin-stabilizing factor. Plasminogen may be removed by adsorption with charcoal. The fibrinogen preparations exhibit marked stability to freezing, lyophilization, and dialysis. Epsilon-amino-n-caproic acid and gamma-aminobutyric acid which were also studied have the property of precipitating proteins from plasma but lack the specificity for fibrinogen found with β-alanine.

Understanding Schizophrenia: Genetic Causes and Treatment

2019 ◽  
Vol 1 (1) ◽  
pp. 6-12
Author(s):  
Fatima Javeria ◽  
Shazma Altaf ◽  
Alishah Zair ◽  
Rana Khalid Iqbal
Keyword(s):  
Copy Number ◽  
Drug Targets ◽  
Disease Risk ◽  
Mental Disease ◽  
Copy Number Variants ◽  
Aminobutyric Acid ◽  
Epigenetic Mechanisms ◽  
Gamma Aminobutyric Acid ◽  
Wide Range ◽  
Severe Mental Disease

Schizophrenia is a severe mental disease. The word schizophrenia literally means split mind. There are three major categories of symptoms which include positive, negative and cognitive symptoms. The disease is characterized by symptoms of hallucination, delusions, disorganized thinking and speech. Schizophrenia is related to many other mental and psychological problems like suicide, depression, hallucinations. Including these, it is also a problem for the patient’s family and the caregiver. There is no clear reason for the disease, but with the advances in molecular genetics; certain epigenetic mechanisms are involved in the pathophysiology of the disease. Epigenetic mechanisms that are mainly involved are the DNA methylation, copy number variants. With the advent of GWAS, a wide range of SNPs is found linked with the etiology of schizophrenia. These SNPs serve as ‘hubs’; because these all are integrating with each other in causing of schizophrenia risk. Until recently, there is no treatment available to cure the disease; but anti-psychotics can reduce the disease risk by minimizing its symptoms. Dopamine, serotonin, gamma-aminobutyric acid, are the neurotransmitters which serve as drug targets in the treatment of schizophrenia. Due to the involvement of genetic and epigenetic mechanisms, drugs available are already targeting certain genes involved in the etiology of the disease.

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