Role of presynaptic serotonergic receptors on the mechanism of action of 5-HT1A and 5-HT1B agonists on masculine sexual behaviour: physiological and pharmacological implications

1991 ◽  
Vol 85 (2) ◽  
pp. 95-107 ◽  
Author(s):  
A. Fern�ndez-Guasti ◽  
A. Escalante
Keyword(s):  
Mechanism Of Action ◽  
Sexual Behaviour ◽  
Serotonergic Receptors ◽  
Masculine Sexual Behaviour

Sex differences in behavioural androgen sensitivity: possible role of androgen metabolism

1984 ◽  
Vol 100 (2) ◽  
pp. 245-248 ◽  
Author(s):  
A. Mode ◽  
J.-Å. Gustafsson ◽  
P. Södersten ◽  
P. Eneroth
Keyword(s):  
Sex Difference ◽  
Sexual Behaviour ◽  
Behavioural Response ◽  
Female Rats ◽  
Male Rats ◽  
Androgen Metabolism ◽  
Target Organs ◽  
Androgen Sensitivity ◽  
Masculine Sexual Behaviour

ABSTRACT Masculine sexual behaviour was induced in castrated sexually inactive but experienced male rats by testosterone-filled constant-release implants or daily injections of the synthetic androgen 17β-hydroxy-17α-methyl-estra-4,9,11-triene-3-one (methyltrienolone, R 1881), which resists metabolism by target organs. Feminization of the hepatic androgen metabolism by subcutaneous implantation of osmotic minipumps, which delivered a constant amount of human GH, did not affect the behavioural response of castrated rats to testosterone. Testosterone implants were only minimally effective in inducing male behaviour in ovariectomized female rats, but R 1881 was as effective in stimulating male behaviour in females as in males. Testosterone-treated but not R 1881-treated females showed pronounced female sexual behaviour in response to progesterone treatment despite the absence of measureable amounts of oestradiol-17β in peripheral blood. The results provide evidence that masculine sexual behaviour can be activated by an androgen in the absence of oestrogenic stimulation and suggest that the sex difference in the behavioural response to testosterone may be due to a sex difference in the metabolism of androgens by the brain. J. Endocr. (1984) 100, 245–248

SOME ASPECTS OF THE FUNCTION OF FSH- AND LH-LIKE HORMONES IN NORMAL AND HYPOPHYSECTOMIZED FEMALE RATS, IN CONNECTION WITH RESERPINE ADMINISTRATION

1965 ◽  
Vol 49 (1) ◽  
pp. 28-38
Author(s):  
M. Grönroos ◽  
E. Mäkinen ◽  
K. Lahtinen ◽  
R. Tirri
Keyword(s):  
Mechanism Of Action ◽  
Biological Effect ◽  
Female Rats ◽  
Histological Picture ◽  
Peripheral Effect ◽  
Pituitary Secretion

ABSTRACT The effect of reserpine on the secretion of FSH and LH was studied as well as the role of the peripheral effect of reserpine after hypophysectomy. The results in the unoperated animals suggest that reserpine inhibits the pituitary secretion of both FSH and LH. Both these hormones combined with reserpine had a very different biological effect than was seen without reserpine. HCG (LH-like) and particularly PMS (FSH-like) hormones combined with reserpine caused definite enlargement of the ovaries. In the hypophysectomized groups, the effect of the PMS and HCG hormones administered together with reserpine or without it was the same with regard to the weight of the ovaries, but not with regard to their histological picture. On the basis of these results, reserpine may be said to have a peripheral effect although the nature of its mechanism of action is difficult to state. Reserpine probably affects the ovaries by inhibiting the follicular cycle and, consequently, the formation of new and more mature follicles.

Role of Flavonoids in Neurodegenerative Disorders with Special Emphasis on Tangeritin

2019 ◽  
Vol 18 (8) ◽  
pp. 581-597 ◽  
Author(s):  
Ambreen Fatima ◽  
Yasir Hasan Siddique
Keyword(s):  
Medicinal Plants ◽  
Mechanism Of Action ◽  
Neurodegenerative Disorders ◽  
Treatment Strategies ◽  
Dietary Supplementation ◽  
Plant Polyphenols ◽  
Promising Candidate ◽  
Naturally Occurring ◽  
The Brain

Flavonoids are naturally occurring plant polyphenols found universally in all fruits, vegetables and medicinal plants. They have emerged as a promising candidate in the formulation of treatment strategies for various neurodegenerative disorders. The use of flavonoid rich plant extracts and food in dietary supplementation have shown favourable outcomes. The present review describes the types, properties and metabolism of flavonoids. Neuroprotective role of various flavonoids and the possible mechanism of action in the brain against the neurodegeneration have been described in detail with special emphasis on the tangeritin.

scholarly journals The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species

2021 ◽  
pp. 107916
Author(s):  
Brandán Pedre ◽  
Uladzimir Barayeu ◽  
Daria Ezeriņa ◽  
Tobias P. Dick
Keyword(s):  
Mechanism Of Action ◽  
Sulfur Species ◽  
Sulfane Sulfur

Role of cyclic nucleotides in the mechanism of action of enkephalins

1982 ◽  
Vol 93 (3) ◽  
pp. 265-267
Author(s):  
M. Ya. Maizelis ◽  
A. L. Zabludovskii ◽  
S. N. Shikhov
Keyword(s):  
Mechanism Of Action ◽  
Cyclic Nucleotides

EFFECT OF PROSTAGLANDIN E2 ON MASCULINE SEXUAL BEHAVIOUR IN THE RAT

1977 ◽  
Vol 75 (3) ◽  
pp. 383-389 ◽  
Author(s):  
L. G. CLEMENS ◽  
B. A. GLADUE
Keyword(s):  
Prostaglandin E2 ◽  
Sexual Behaviour ◽  
Testosterone Propionate ◽  
Prostaglandin E ◽  
Intracerebral Infusion ◽  
Masculine Sexual Behaviour ◽  
Copulatory Behaviour

Intracerebral infusion of prostaglandin E2 (PGE2) facilitated copulatory behaviour of longterm castrated rats. Castrated rats were given daily systemic injections of testosterone propionate (50 pg) or oil vehicle, and then 30 min before behavioural testing they received an intrahypothalamic infusion of either PGE2 or saline. Rats receiving PGE2 in addition to systemic testosterone showed more copulatory behaviour than those receiving PGE2 or testosterone alone.

The role of neurotensin in the pathophysiology of schizophrenia and the mechanism of action of antipsychotic drugs

2001 ◽  
Vol 50 (11) ◽  
pp. 856-872 ◽  
Author(s):  
Elisabeth B Binder ◽  
Becky Kinkead ◽  
Michael J Owens ◽  
Charles B Nemeroff
Keyword(s):  
Mechanism Of Action ◽  
Antipsychotic Drugs
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