The fall of homovanillic acid and 5-hydroxyindoleacetic acid concentrations in brains of mice withdrawn from repeated morphine treatment and their restoration by acute morphine administration

1987 ◽  
Vol 68 (1-2) ◽  
pp. 63-78 ◽  
Author(s):  
L. Ahtee ◽  
P. Attila ◽  
V. Lauhakangas ◽  
A. Solkinen ◽  
J. Sipil�
Keyword(s):  
Homovanillic Acid ◽  
Morphine Treatment ◽  
Morphine Administration ◽  
Hydroxyindoleacetic Acid

Noradrenergic Overactivity in Chronic Schizophrenia: Evidence Based on Cerebrospinal Fluid Noradrenaline and Cyclic Nucleotide Concentrations

1980 ◽  
Vol 137 (4) ◽  
pp. 346-351 ◽  
Author(s):  
U. C. R. Gomes ◽  
B. C. Shanley ◽  
L. Potgieter ◽  
J. T. Roux
Keyword(s):  
Cerebrospinal Fluid ◽  
Cyclic Nucleotides ◽  
Homovanillic Acid ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Chronic Schizophrenia ◽  
Evidence Based ◽  
Chronic Schizophrenics ◽  
Hydroxyindoleacetic Acid ◽  
Lumbar Cerebrospinal Fluid

SummaryConcentrations of noradrenaline (NA), homovanillic acid, 5-hydroxyindoleacetic acid and cyclic nucleotides were determined in lumbar cerebrospinal fluid (CSF) from acute and chronic schizophrenics and various groups of psychiatric and non-psychiatric control subjects. Statistically significant increases in NA and cyclic adenosine monophosphate were found in CSF from chronic schizophrenics compared to all other groups. These results were shown by statistical analyses to be unrelated to medication. They may be interpreted as evidence for noradrenergic overactivity as a possible primary abnormality in chronic schizophrenia.

Use of alumina, sephadex G10, and ion-exchange columns to purify samples for determination of epinephrine, norepinephrine, dopamine, homovanillic acid, and 5-hydroxyindoleacetic acid in urine.

1982 ◽  
Vol 28 (8) ◽  
pp. 1745-1748 ◽  
Author(s):  
B H Westerink ◽  
F J Bosker ◽  
J F O'Hanlon
Keyword(s):  
Ion Exchange ◽  
High Performance ◽  
Homovanillic Acid ◽  
Clinical Chemistry ◽  
Simultaneous Quantification ◽  
Analytical Recovery ◽  
Hydroxyindoleacetic Acid ◽  
One Year ◽  
Catecholamines In Urine

Abstract We investigated the usefulness of small Sephadex columns, prepared in Pasteur pipettes, in purifying samples to be analyzed for catecholamines, homovanillic acid, and 5-hydroxyindoleacetic acid. After free catecholamines in urine samples were purified on alumina followed by Sephadex G10, a reliable and simultaneous quantification of epinephrine, norepinephrine, and dopamine was achieved by using high-performance liquid-chromatography with electrochemical detection. Purification of urine on Bio-Rad prepacked ion-exchange columns followed by Sephadex G10 resulted in a reliable, fast (200 samples processed per week) method for determination of free catecholamines in urine. Analytical recoveries of both methods were between 80 and 95%, with a CV of about 3%. Single purification on Sephadex G10 sufficed to allow simultaneous determination of homovanillic acid and 5-hydroxyindoleacetic acid in urine. Analytical recovery for this method was about 90%, with a CV of about 5%. Sephadex G10 columns, which can be re-used without regeneration for at least one year, appear to have a great potential in clinical chemistry.

Monoamines and CSF: relevance to neuropsychiatric disorders

1992 ◽  
Vol 4 (3) ◽  
pp. 47-51
Author(s):  
W.M.A. Verhoeven
Keyword(s):  
Homovanillic Acid ◽  
Neuropsychiatric Disorders ◽  
Endogenous Depression ◽  
Research Strategy ◽  
Future Research ◽  
Monoamine Metabolites ◽  
The Past ◽  
Hydroxyindoleacetic Acid ◽  
Functional Psychopathology ◽  
The Relationship

SummaryOver the past 25 years much effort has been put into the research of the relationship between neuropsychiatric disorders and the concentrations of CSF-monoamine metabolites. Most of this research has beenfocused on the relation between CSF-concentrations of 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) and specific symptomatological entities, particularly schizophrenia, Alzheimer's dementia and endogenous depression. It appeared that specific relations between diseases and CSF-concentrations of monoamine metabolites cannot be longer maintained and that a more functional psychopathology should be considered as the future research strategy.

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