Infectious influenza virus-antibody complex

1971 ◽  
Vol 34 (3) ◽  
pp. 209-213 ◽  
Author(s):  
E. Zalan ◽  
E. Borman ◽  
N. A. Labzoffsky
2013 ◽  
Vol 16 (4) ◽  
pp. 663-669
Author(s):  
W. Rozek ◽  
M. Kwasnik ◽  
J.F. Zmudzinski

AbstractChanges in the level of cellular proteins in cells inoculated with equine influenza virus H7N7 and H3N8 were studied with microarray technique. H3N8 induced pro-apoptotic proteins while H7N7 induced both pro- as well as anti-apoptotic factors. The higher level of some cytoskeleton components and proteins involved in the protein quality control was recorded. Relatively high number of proteins involved in the regulation of transcription was down-regulated. The pattern of changes observed for H7N7 and H3N8 may reflect differences in the biological properties of both serotypes.


Virology ◽  
1963 ◽  
Vol 20 (3) ◽  
pp. 457-463 ◽  
Author(s):  
Francisco Pinheiro ◽  
G.D. Hsiung

1966 ◽  
Vol 124 (1) ◽  
pp. 81-97 ◽  
Author(s):  
Abner Louis Notkins ◽  
Suellen Mahar ◽  
Christina Scheele ◽  
Joel Goffman

If viremic sera from mice chronically infected with lactic dehydrogenase virus (LDV) were first treated with ether or ultraviolet light to inactivate the infectious virus, neutralizing antibody could be demonstrated. Significant amounts of antibody, however, were not detected until the mice had been infected for about 2½ months and its presence did not result in the elimination of the chronic viremia. Virus isolated from sera containing neutralizing antibody was found to be relatively resistant to neutralization by anti-LDV. Further studies revealed that the resistant virus existed in the form of an infectious virus-antibody complex (sensitized virus). The presence of such a complex was demonstrated by the fact that the virus fraction which persisted after in vivo or in vitro exposure to mouse anti-LDV was readily neutralized by goat anti-mouse sera or goat anti-mouse γ-globulin, whereas virus that had not been previously exposed to mouse anti-LDV was completely resistant to neutralization by goat anti-mouse sera. These findings suggest that (a) sensitization may play an important role in the resistance and susceptibility of a virus to neutralization by antiviral antibody, and (b) an anti-γ-globulin may prove useful in neutralizing the resistant fraction and in demonstrating otherwise undetectable antiviral antibody.


1985 ◽  
Vol 47 (4) ◽  
pp. 633-638 ◽  
Author(s):  
Toshihiro HIRANO ◽  
Yoshitaka OGAWA ◽  
Hitoshi GOTO ◽  
Kiheiji SHIMIZU ◽  
Shinichi NORO ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document