Assessment of proliferating-cell nuclear antigen immunostaining in soft-tissue tumours: Relationship to histological grade and mitotic activity

1994 ◽  
Vol 120 (7) ◽  
pp. 393-398 ◽  
Author(s):  
Penelope Korkolopoulou ◽  
Panayota Christodoulou ◽  
Athanasios Papanikolaou ◽  
Artemis Tsenga ◽  
Euphemia Thomas-Tsagli
Keyword(s):  
Soft Tissue ◽  
Mitotic Activity ◽  
Proliferating Cell Nuclear Antigen ◽  
Histological Grade ◽  
Nuclear Antigen ◽  
Soft Tissue Tumours ◽  
Proliferating Cell

Proliferating cell nuclear antigen and mitotic activity in rectal cancer: predictor of response to preoperative irradiation.

1994 ◽  
Vol 12 (4) ◽  
pp. 679-682 ◽  
Author(s):  
C G Willett ◽  
G Warland ◽  
R Cheek ◽  
J Coen ◽  
J Efird ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Mitotic Activity ◽  
Proliferating Cell Nuclear Antigen ◽  
Residual Disease ◽  
Tumor Regression ◽  
Rectal Wall ◽  
Clinical Stage ◽  
Nuclear Antigen ◽  
Preoperative Irradiation ◽  
Proliferating Cell

PURPOSE This study examines the association between the pathologic response of rectal cancer after irradiation and its pretreatment proliferative state as assayed by proliferating cell nuclear antigen (PCNA) and mitotic activity. PATIENTS AND METHODS Ninety patients with clinical stage T3 and T4 rectal cancer received preoperative irradiation followed by surgery. Pretreatment tumor biopsies were scored for PCNA activity (number of tumor cells staining immunohistochemically with an anti-PCNA monoclonal antibody) and the number of mitoses per 10 high-powered fields (hpf). Postirradiation surgical specimens were examined for extent of residual disease. RESULTS The tumors of 33 of 90 patients (37%) exhibited marked pathologic downstaging (no residual tumor or cancer confined to the rectal wall) after preoperative irradiation. Two features were independently associated with the likelihood of marked pathologic regression after preoperative irradiation: lesion size and PCNA/mitotic activity. When stratified by tumor size, marked tumor regression occurred most frequently in smaller tumors with high PCNA/mitotic activity compared with larger tumors with lower PCNA/mitotic activity. Intermediate downstaging rates were seen for small or large tumors with moderate PCNA/mitotic activity. CONCLUSION Tumor PCNA/mitotic activity predicts the likelihood of response to irradiation, which may aid in formulating treatment policies for patients with rectal cancer.

Expression of proliferating cell nuclear antigen (PCNA) and Ki-67 in soft tissue sarcoma. Is prognostic significance histotype-specific?

Apmis ◽  
1995 ◽  
Vol 103 (7-8) ◽  
pp. 797-805 ◽  
Author(s):  
PETER F. M. CHOONG ◽  
MÅNS ÅKERMAN ◽  
HELENA WILLÉN ◽  
CHRISTINA ANDERSSON ◽  
PELLE GUSTAFSON ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Proliferating Cell Nuclear Antigen ◽  
Prognostic Significance ◽  
Nuclear Antigen ◽  
Ki 67 ◽  
Proliferating Cell
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