scholarly journals Monoamine oxidase and catechol-o-methyltransferase activity in hamster and rat insulinomas

Diabetologia ◽  
1979 ◽  
Vol 17 (4) ◽  
pp. 249-256 ◽  
Author(s):  
J. M. Feldman ◽  
D. S. Reintgen ◽  
H. F. Seigler
1983 ◽  
Vol 12 (1) ◽  
pp. 85-91 ◽  
Author(s):  
O.P. Agarwal ◽  
G. Philippu ◽  
U. Milech ◽  
B. Ziemsen ◽  
O. Schrappe ◽  
...  

1976 ◽  
Vol 51 (s3) ◽  
pp. 395s-397s
Author(s):  
M. Iijima ◽  
Y. Kitamura ◽  
N. Yamamoto ◽  
H. Kawamura ◽  
T. Yasugi ◽  
...  

1. Intravenous administration of angiotensin II reduced the adrenaline content, increased the catechol-O-methyltransferase activity, and decreased the monoamine oxidase activity of the rat hypothalamus. 2. Intraventricularly administered angiotensin II reduced the noradrenaline content to a smaller extent. 3. The change produced by intravenous administration of angiotensin might be indirectly caused by a response to angiotensin.


Author(s):  
Martin Hagopian ◽  
Michael D. Gershon ◽  
Eladio A. Nunez

The ability of cardiac tissues to take up norepinephrine from an external medium is well known. Two mechanisms, called Uptake and Uptake respectively by Iversen have been differentiated. Uptake is a high affinity system associated with adrenergic neuronal elements. Uptake is a low affinity system, with a higher maximum rate than that of Uptake. Uptake has been associated with extraneuronal tissues such as cardiac muscle, fibroblasts or vascular smooth muscle. At low perfusion concentrations of norepinephrine most of the amine taken up by Uptake is metabolized. In order to study the localization of sites of norepinephrine storage following its uptake in the active bat heart, tritiated norepinephrine (2.5 mCi; 0.064 mg) was given intravenously to 2 bats. Monoamine oxidase had been inhibited with pheniprazine (10 mg/kg) one hour previously to decrease metabolism of norepinephrine.


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