scholarly journals The direct effect of hypoglycaemic sulphonylureas on myocardial contractile force and arterial blood pressure

Diabetologia ◽  
1977 ◽  
Vol 13 (5) ◽  
pp. 515-519 ◽  
Author(s):  
G. Pog�tsa ◽  
E. Dubecz
Keyword(s):  
Blood Pressure ◽  
Arterial Blood Pressure ◽  
Direct Effect ◽  
Contractile Force ◽  
Arterial Blood ◽  
Myocardial Contractile Force ◽  
Myocardial Contractile ◽  
Hypoglycaemic Sulphonylureas

Eugenol: Some Pharmacologic Observations

1971 ◽  
Vol 50 (6) ◽  
pp. 1531-1535 ◽  
Author(s):  
Frank D. Sticht ◽  
Roy M. Smith
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Blood Flow ◽  
Circulatory System ◽  
Electric Activity ◽  
Contractile Force ◽  
Arterial Blood ◽  
Myocardial Contractile Force ◽  
Myocardial Contractile ◽  
Increased Blood Flow

Eugenol introduced directly into the circulatory system of the dog caused a strong but transient reduction in arterial blood pressure and myocardial contractile force, without appreciably changing heart rate or electric activity. Intra-arterial injection of the drug resulted in increased blood flow to the region.

scholarly journals Effect of erythrocyte mass on arterial blood pressure in dialysis patients receiving maintenance erythropoietin therapy.

1994 ◽  
Vol 4 (11) ◽  
pp. 1874-1878 ◽  
Author(s):  
C J Kaupke ◽  
S Kim ◽  
N D Vaziri
Keyword(s):  
Blood Pressure ◽  
Arterial Blood Pressure ◽  
Direct Effect ◽  
Chronic Hemodialysis ◽  
Significant Rise ◽  
Iron Stores ◽  
Human Erythropoietin ◽  
Arterial Blood ◽  
Target Values ◽  
Iv Iron

Treatment of renal anemia with recombinant human erythropoietin (rEPO) frequently raises arterial blood pressure. The objective of this study was to determine whether this is a direct effect of rEPO or a consequence of the expansion of erythrocyte mass. Twenty-three chronic hemodialysis patients receiving maintenance rEPO therapy who had uncontrolled anemia due to iron deficiency were studied. It was anticipated that repletion of iron stores with iv iron dextran would restore rEPO responsiveness, leading to a gradual rise in hematocrit to the target values (0.30 to 0.33). The effect of the increase in hematocrit on arterial blood pressure could then be dissected from the direct effect of rEPO in patients receiving constant doses of rEPO throughout the study period. To this end, arterial blood pressure, iron indices, hematocrit, and measures of fluid balance were monitored at baseline and for a 10-wk period after iron repletion. In eight patients, the hematocrit transiently rose above 0.33, triggering a reduction in rEPO dosage. In the remaining 15 patients, rEPO dosage was held constant during the study period. In this subgroup, repletion of iron stores led to a rise in hematocrit from 0.25 +/- 0.04 to 0.32 +/- 0.04 (P < 0.001) within 4 wk. Despite the significant rise in hematocrit, both systolic and diastolic blood pressure values remained virtually unchanged. Likewise, body weight and interdialytic fluid gain were unaltered.(ABSTRACT TRUNCATED AT 250 WORDS)

Effects of N-Acetylprocainamide and Procainamide on Myocardial Contractile Force, Heart Rate, and Blood Pressure

1979 ◽  
Vol 161 (3) ◽  
pp. 332-336 ◽  
Author(s):  
J. J. L. Lertora ◽  
D. Glock ◽  
G. P. Stec ◽  
A. J. Atkinson ◽  
L. I. Goldberg
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Contractile Force ◽  
Myocardial Contractile Force ◽  
Myocardial Contractile

Cardiovascular Effects of Micromeria graeca (L.) Benth. ex Rchb in Normotensive and Hypertensive Rats

2020 ◽  
Vol 20 (8) ◽  
pp. 1253-1261
Author(s):  
Mourad Akdad ◽  
Mohamed Eddouks
Keyword(s):  
Blood Pressure ◽  
Cardiovascular System ◽  
Arterial Blood Pressure ◽  
Antihypertensive Activity ◽  
Computer Assisted ◽  
Hypertensive Rats ◽  
Vasorelaxant Effect ◽  
Arterial Blood

Aims: The present study was performed in order to analyze the antihypertensive activity of Micromeria graeca (L.) Benth. ex Rchb. Background: Micromeria graeca (L.) Benth. ex Rchb is an aromatic and medicinal plant belonging to the Lamiaceae family. This herb is used to treat various pathologies such as cardiovascular disorders. Meanwhile, its pharmacological effects on the cardiovascular system have not been studied. Objective: The present study aimed to evaluate the effect of aqueous extract of aerial parts of Micromeria graeca (AEMG) on the cardiovascular system in normotensive and hypertensive rats. Methods: In this study, the cardiovascular effect of AEMG was evaluated using in vivo and in vitro investigations. In order to assess the acute effect of AEMG on the cardiovascular system, anesthetized L-NAME-hypertensive and normotensive rats received AEMG (100 mg/kg) orally and arterial blood pressure parameters were monitored during six hours. In the sub-chronic study, rats were orally treated for one week, followed by blood pressure assessment during one week of treatment. Blood pressure was measured using a tail-cuff and a computer-assisted monitoring device. In the second experiment, isolated rat aortic ring pre-contracted with Epinephrine (EP) or KCl was used to assess the vasorelaxant effect of AEMG. Results: Oral administration of AEMG (100 mg/kg) provoked a decrease of arterial blood pressure parameters in hypertensive rats. In addition, AEMG induced a vasorelaxant effect in thoracic aortic rings pre-contracted with EP (10 μM) or KCl (80 mM). This effect was attenuated in the presence of propranolol and methylene blue. While in the presence of glibenclamide, L-NAME, nifedipine or Indomethacin, the vasorelaxant effect was not affected. Conclusion: This study showed that Micromeria graeca possesses a potent antihypertensive effect and relaxes the vascular smooth muscle through β-adrenergic and cGMP pathways.

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