Regional mapping of the gene encoding dihydroorotate dehydrogenase, an enzyme involved in UMP synthesis, electron transport, and superoxide generation, to human chromosome region 16q22

1993 ◽  
Vol 19 (4) ◽  
pp. 405-411 ◽  
Author(s):  
Tristan Barnes ◽  
Preston Parry ◽  
Iris Hart ◽  
Carol Jones ◽  
Michele Minet ◽  
...  
Keyword(s):  
Electron Transport ◽  
Human Chromosome ◽  
Chromosome Region ◽  
Regional Mapping ◽  
Dihydroorotate Dehydrogenase ◽  
Superoxide Generation ◽  
Gene Encoding ◽  
Ump Synthesis

The Gene Encoding Protein Kinase SEK1 Maps to Mouse Chromosome 11 and Human Chromosome 17

Genomics ◽  
1996 ◽  
Vol 34 (3) ◽  
pp. 430-432 ◽  
Author(s):  
Robert A. White ◽  
Rowland T. Hughes ◽  
Linda R. Adkison ◽  
Gail Bruns ◽  
Leonard I. Zon
Keyword(s):  
Protein Kinase ◽  
Human Chromosome ◽  
Mouse Chromosome ◽  
Chromosome 17 ◽  
Chromosome 11 ◽  
Gene Encoding ◽  
Human Chromosome 17 ◽  
Mouse Chromosome 11 ◽  
Encoding Protein

scholarly journals Effects of Atovaquone and Diospyrin-Based Drugs on the Cellular ATP of Pneumocystis carinii f. sp.carinii

2000 ◽  
Vol 44 (3) ◽  
pp. 713-719 ◽  
Author(s):  
Melanie T. Cushion ◽  
Margaret Collins ◽  
Banasri Hazra ◽  
Edna S. Kaneshiro
Keyword(s):  
Electron Transport ◽  
Drug Target ◽  
Coenzyme Q ◽  
Pneumocystis Carinii ◽  
Atp Depletion ◽  
Malarial Parasite ◽  
Dihydroorotate Dehydrogenase ◽  
Atp Levels ◽  
Transport Chain ◽  
Kinetics Of

ABSTRACT Atovaquone (also called Mepron, or 566C80) is a napthoquinone used for the treatment of infections caused by pathogens such asPlasmodium spp. and Pneumocystis carinii. The mechanism of action against the malarial parasite is the inhibition of dihydroorotate dehydrogenase (DHOD), a consequence of blocking electron transport by the drug. As an analog of ubiquinone (coenzyme Q [CoQ]), atovaquone irreversibly binds to the mitochondrial cytochrome bc 1 complex; thus, electrons are not able to pass from dehydrogenase enzymes via CoQ to cytochrome c. Since DHOD is a critical enzyme in pyrimidine biosynthesis, and because the parasite cannot scavenge host pyrimidines, the drug is lethal to the organism. Oxygen consumption inP. carinii is inhibited by the drug; thus, electron transport has also been identified as the drug target in P. carinii. However, unlike Plasmodium DHOD, P. carinii DHOD is inhibited only at high atovaquone concentrations, suggesting that the organism may salvage host pyrimidines and that atovaquone exerts its primary effects on ATP biosynthesis. In the present study, the effect of atovaquone on ATP levels in P. carinii was measured directly from 1 to 6 h and then after 24, 48, and 72 h of exposure. The average 50% inhibitory concentration after 24 to 72 h of exposure was 1.5 μg/ml (4.2 μM). The kinetics of ATP depletion were in contrast to those of another family of naphthoquinone compounds, diospyrin and two of its derivatives. Whereas atovaquone reduced ATP levels within 1 h of exposure, the diospyrins required at least 48 h. After 72 h, the diospyrins were able to decrease ATP levels of P. carinii at nanomolar concentrations. These data indicate that although naphthoquinones inhibit the electron transport chain, the molecular targets in a given organism are likely to be distinct among members of this class of compounds.

Regional mapping of a liver α-subunit gene of phosphorylase kinase (PHKA) to the distal region of human chromosome Xp

1992 ◽  
Vol 60 (3-4) ◽  
pp. 194-196 ◽  
Author(s):  
J.G. Wauters ◽  
P.J. Bossuyt ◽  
J. Davidson ◽  
J. Hendrickx ◽  
M.W. Kilimann ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Distal Region ◽  
Alpha Subunit ◽  
Phosphorylase Kinase ◽  
Regional Mapping ◽  
Subunit Gene

Regional localization of the LCA oncogene to human chromosome region 2q14→q21

1988 ◽  
Vol 48 (1) ◽  
pp. 63-64 ◽  
Author(s):  
T. Tokino ◽  
H. Satoh ◽  
M.C. Yoshida ◽  
T. Ochiya ◽  
K. Matsubara
Keyword(s):  
Human Chromosome ◽  
Chromosome Region ◽  
Regional Localization

Assignment of the gene coding for both the β-subunit of prolyl 4-hydroxylase and the enzyme disulfide isomerase to human chromosome region 17p11→qter

1988 ◽  
Vol 47 (1-2) ◽  
pp. 37-41 ◽  
Author(s):  
L. Pajunen ◽  
R. Myllylä ◽  
T. Helaakoski ◽  
T. Pihlajaniemi ◽  
K. Tasanen ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Chromosome Region ◽  
Beta Subunit ◽  
Disulfide Isomerase ◽  
Gene Coding

Assignment1 of SND1, the gene encoding coactivator p100, to human chromosome 7q31.3 and rat chromosome 4q23 by in situ hybridization

2000 ◽  
Vol 90 (3-4) ◽  
pp. 253-254 ◽  
Author(s):  
P. Liénard ◽  
M. Rivière ◽  
P. van Vooren ◽  
C. Szpirer ◽  
J. Szpirer
Keyword(s):  
In Situ Hybridization ◽  
Human Chromosome ◽  
Gene Encoding

The Gene Encoding the GPI-Anchored Membrane Protein p137GPI(M11S1) Maps to Human Chromosome 11p13 and Is Highly Conserved in the Mouse

Genomics ◽  
1996 ◽  
Vol 32 (1) ◽  
pp. 169-170 ◽  
Author(s):  
M. Gessler ◽  
B. Klamt ◽  
S. Tsaoussidou ◽  
J.A. Ellis ◽  
J.P. Luzio
Keyword(s):  
Membrane Protein ◽  
Human Chromosome ◽  
Gene Encoding
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