scholarly journals Increased sensitivity of diabetic rat adipose tissue towards the lipolytic action of epinephrine

Diabetologia ◽  
1975 ◽  
Vol 11 (6) ◽  
pp. 509-516 ◽  
Author(s):  
J. Zapf ◽  
D. Feuerlein ◽  
M. Waldvogel ◽  
E. R. Froesch
Keyword(s):  
Adipose Tissue ◽  
Diabetic Rat ◽  
Lipolytic Action ◽  
Increased Sensitivity ◽  
Rat Adipose Tissue

scholarly journals Proinsulin C-Peptide Inhibits Lipolysis in Diabetic Rat Adipose Tissue Through Phosphodiestrase-3B Enzyme

2012 ◽  
Vol 45 (03) ◽  
pp. 221-225 ◽  
Author(s):  
A. Ghorbani ◽  
G. Omrani ◽  
M. Hadjzadeh ◽  
M. Varedi
Keyword(s):  
Adipose Tissue ◽  
Diabetic Rat ◽  
C Peptide ◽  
Rat Adipose Tissue

OBSERVATIONS ON THE LIPOLYTIC ACTION IN VITRO OF A FAT-MOBILIZING SUBSTANCE EXTRACTED FROM URINE OF FASTING RATS

1966 ◽  
Vol 44 (1) ◽  
pp. 103-113 ◽  
Author(s):  
John R. Beaton ◽  
A. J. Szlavko ◽  
J. A. F. Stevenson
Keyword(s):  
Adipose Tissue ◽  
Young Male ◽  
High Protein Diet ◽  
Inhibitory Effect ◽  
Male Rat ◽  
Lipolytic Action ◽  
Electrolytic Ablation ◽  
Rat Adipose Tissue

An investigation has been carried out of factors in the lipolytic response of adipose tissue to a fat-mobilizing substance (FMS IB) extracted from the urine of fasting rats. Response was increased when rats were exposed to cold prior to removal of adipose tissue and was decreased in adipose tissue of rats rendered hyperphagic and obese by bilateral electrolytic ablation of the ventromedial region of the hypothalamus. These observations in vitro are consistent with observations on fat catabolism or storage in vivo after cold exposure and in hypothalamic hyperphagia.Previous feeding of a high-protein diet inhibited lipolytic response in vitro of adipose tissue to both FMS IB and adrenaline; previous feeding of a noncarbohydrate high-fat diet also inhibited lipolytic response to FMS IB but not to adrenaline. Of the adipose tissues tested, lipolytic response to FMS IB was in the order epididymal > perinephric > omentum. There was no sex difference in the response of adipose tissue; the response of adipose tissue of the young male rat was considerably less than that of the adult male rat. Adipose tissue of fasted rats was much more responsive to FMS IB than was that of fed rats. This response could be almost completely abolished by the addition of glucose (180 mg/100 ml) to the incubating medium; lesser concentrations of glucose had a smaller inhibitory effect. A linear lipolytic response of adipose tissue to increasing amounts of FMS IB has been demonstrated.

scholarly journals Lipolytic Action of Corticotropin on Rat Adipose Tissue In Vitro12

1958 ◽  
Vol 37 (11) ◽  
pp. 1556-1563 ◽  
Author(s):  
J. Earle White ◽  
Frank L. Engel
Keyword(s):  
Adipose Tissue ◽  
Lipolytic Action ◽  
Rat Adipose Tissue

scholarly journals Changes in the anti-lipolytic action and binding to plasma membranes of N6-L-phenylisopropyladenosine in adipocytes from starved and hypothyroid rats

1984 ◽  
Vol 223 (1) ◽  
pp. 53-59 ◽  
Author(s):  
P Chohan ◽  
C Carpenter ◽  
E D Saggerson
Keyword(s):  
Adipose Tissue ◽  
Adenosine Deaminase ◽  
Binding Sites ◽  
Plasma Membranes ◽  
High Concentration ◽  
Lipolytic Action ◽  
Increased Sensitivity ◽  
Adipose Tissue Lipolysis ◽  
Adenosine Analogue ◽  
Adipocyte Plasma Membranes

The anti-lipolytic effect of the adenosine analogue N6-L-phenylisopropyladenosine was studied with rat adipocytes incubated with a high concentration of adenosine deaminase (0.5 unit/ml, approx. 2.5 micrograms/ml) and concentrations of noradrenaline that were equieffective in different physiological states. These studies were performed to compare the fed and starved (24h) states and to compare a hypothyroid state (induced by feeding propylthiouracil + a low-iodine diet) with the euthyroid state. Starvation increased sensitivity of the cells to the lipolytic action of noradrenaline, while decreasing sensitivity to the antilipolytic action of phenylisopropyladenosine. Hypothyroidism resulted in decreased sensitivity to noradrenaline and increased sensitivity to phenylisopropyladenosine. Studies of the binding of [3H]phenylisopropyladenosine to adipocyte plasma membranes indicated heterogeneity of binding sites or negative co-operativity in the binding. Starvation did not change [3H]phenylisopropyladenosine binding to membranes, whereas hypothyroidism caused an unexpected decrease in both the number and affinity of the binding sites. These observations are discussed in terms of the dual regulation of adipose-tissue lipolysis by lipolytic and anti-lipolytic agents.

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