scholarly journals Decreased cyclic AMP and Insulin responses to glucose in pancreatic islets of diabetic chinese hamsters

Diabetologia ◽  
1976 ◽  
Vol 12 (6) ◽  
pp. 581-587 ◽  
Author(s):  
A. Rabinovitch ◽  
A. E. Renold ◽  
E. Cerasi
1979 ◽  
Vol 180 (1) ◽  
pp. 233-236 ◽  
Author(s):  
E G Siegel ◽  
C B Wollheim ◽  
G W Sharp ◽  
L Herberg ◽  
A E Renold

In pancreatic islets from normal Chinese hamsters preloaded with 45Ca2+, glucose-induced biphasic insulin release was associated with increased 45Ca2+ efflux; islets from diabetic hamsters showed decreased insulin release and no increase in 45Ca2+ efflux. The lack of stimulated 45Ca2+ efflux persisted even when glucose-induced insulin release was potentiated by 3-isobutyl-1-methylxanthine. Since glucose-stimulated 45Ca2+ uptake by diabetic islets was not impaired, a defect in intracellular Ca2+ handling may be involved in the defective insulin release of the diabetic Chinese hamster.


1993 ◽  
Vol 39 (1-2) ◽  
pp. 67-72 ◽  
Author(s):  
Barbara J. Frankel ◽  
Olle Korsgren ◽  
Arne Andersson

Diabetologia ◽  
1974 ◽  
Vol 10 (S1) ◽  
pp. 567-579 ◽  
Author(s):  
M. G. Soret ◽  
W. E. Dulin ◽  
J. Mathews ◽  
G. C. Gerritsen

Author(s):  
Akizuki MORIKAWA ◽  
Kiyoshi Watanabe ◽  
Masaaki ETO ◽  
Yasunori IWASHIMA ◽  
Eiji OHSHIMA ◽  
...  

1988 ◽  
Vol 35 (1) ◽  
pp. 1-9 ◽  
Author(s):  
EIJI OSHIMA ◽  
KIYOSHI WATANABE ◽  
KANEO ISHII

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