scholarly journals Inter-relationship between insulin secretion and plasma free fatty acid and triglyceride transport kinetics in maturity onset diabetes and the effect of phenethylbiguanide (Phenformin)

Diabetologia ◽  
1974 ◽  
Vol 10 (2) ◽  
pp. 119-130 ◽  
Author(s):  
A. H. Kissebah ◽  
P. W. Adams ◽  
V. Wynn
Keyword(s):  
Insulin Secretion ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Plasma Free Fatty Acid ◽  
Transport Kinetics ◽  
Maturity Onset Diabetes ◽  
Onset Diabetes

scholarly journals Enhanced insulin secretion and glucose tolerance in rats exhibiting low plasma free fatty acid levels and hypertriglyceridaemia due to congenital albumin deficiency

2012 ◽  
Vol 97 (4) ◽  
pp. 525-533 ◽  
Author(s):  
Tiago R. Figueira ◽  
Rosane A. Ribeiro ◽  
Letícia M. Ignacio-Souza ◽  
Anibal E. Vercesi ◽  
Everardo M. Carneiro ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Glucose Tolerance ◽  
Plasma Free Fatty Acid

Plasma Free Fatty Acid and Triglyceride Transport Kinetics in Man

1974 ◽  
Vol 47 (3) ◽  
pp. 259-278 ◽  
Author(s):  
A. H. Kissebah ◽  
P. W. Adams ◽  
V. Wynn
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Density Lipoprotein ◽  
Plasma Free Fatty Acid ◽  
Compartment Model ◽  
Plasma Triglyceride ◽  
Transport Kinetics ◽  
Plasma Triglyceride Concentration ◽  
Triglyceride Concentration ◽  
Plasma Ffa

1. Studies were carried out to test the assumptions involved in the calculation of free fatty acid (FFA) and triglyceride transport rates from the plasma radioactivity curves after the intravenous administration of labelled fatty acid or of pre-labelled lipoprotein triglyceride. 2. Plasma FFA equilibrates reversibly with the interstitial lymph. This makes it necessary to use either a pulse injection, with analysis of the results in terms of a two-compartment model, or continuous infusion of the label in determining the FFA flux. 3. The recycling of labelled fatty acid due to direct hydrolysis of plasma triglyceride accounted for less than 5% of the total plasma FFA flux and did not appreciably affect the plasma triglyceride disappearance curve after endogenous labelling with 14C-labelled fatty acid. Turnover values calculated from triglyceride in unfractionated plasma represent mainly the very-low-density lipoprotein triglyceride transport. The distribution space of plasma triglyceride was found to be equal to the plasma volume. 4. Our findings suggest a complex relation between plasma triglyceride concentration and its transport kinetics. The plasma triglyceride concentration is determined by the rates of influx and efflux, and this concentration also regulates its own production and removal. Evidence obtained from the endogenous labelling technique and after experimental hypertriglyceridaemia suggests the application of enzyme kinetic models to characterize plasma triglyceride transport.

Respiratory capacity and glycogen depletion in thyroid-deficient muscle

1980 ◽  
Vol 49 (1) ◽  
pp. 102-106 ◽  
Author(s):  
K. M. Baldwin ◽  
A. M. Hooker ◽  
R. E. Herrick ◽  
L. F. Schrader
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Plasma Free Fatty Acid ◽  
Endurance Capacity ◽  
Glycogen Depletion ◽  
Respiratory Capacity ◽  
Rest And Exercise

This study was undertaken to determine the effects of propylthiouracil-induced thyroid deficiency on a) the capacity of muscle homogenates to oxidize [2-14C]pyruvate and [U-14C]palmitate and b) glycogen depletion during exercise in liver and in fast-oxidative-glycogenolytic (FOG), fast-glycogenolytic (FG), and slow-oxidative (SO) muscle. Relative to the rates for normal rats, oxidation with pyruvate was reduced by 53, 68, and 58%, and palmitate by 40, 50, and 48% in FOG, FG, and SO muscle, respectively (P less than 0.05). Normal rats ran longer than thyroid-deficient rats at 26.7 m/min (87 ± 8 vs. 37 ± 5 min). After 40 min of running (22 m/min), the amount of glycogen consumed in normal FOG, FG, and SO muscle and in liver amounted to only 23, 12, 66, and 52%, respectively, of that for their thyroid-deficient counterparts. Also, normal rats maintained higher plasma free fatty acid levels than thyroid-deficient rats during both rest and exercise (P less than 0.05). These findings suggest that thyroid deficiency causes a reduced potential for FFA utilization in skeletal muscle that enhances its consumption of glycogen, thereby limiting endurance capacity.

The Effects of Cold and Prostaglandin E1 on Lipid Mobilization in the Chicken

1971 ◽  
Vol 49 (5) ◽  
pp. 394-398 ◽  
Author(s):  
W. D. Wagner ◽  
R. A. Peterson ◽  
R. J. Cenedella
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Cold Exposure ◽  
Prostaglandin E1 ◽  
Plasma Free Fatty Acid ◽  
Prostaglandin E ◽  
Elevated Plasma ◽  
Lower Plasma ◽  
Lipid Mobilization ◽  
Plasma Ffa

Plasma free fatty acid (FFA) levels and the effects of prostaglandin E1 (PGE1) were studied in cold-acclimated and cold-exposed chickens and compared to controls. Chickens cold-acclimated at 4–7 or 8–11 °C for 4 weeks had significantly elevated plasma FFA when compared to the controls at 19–21 °C. Although PGE1 had no effect on the basal level of FFA of controls, a significantly lower plasma FFA was seen after injection of either 10 or 30 μg PGE1/kg in cold-acclimated chickens. Chickens cold-exposed to 2–3 °C for 4 h demonstrated significant elevations of plasma FFA when compared to controls. Only 30 μg PGE1/kg significantly depressed the plasma FFA in the cold-exposed birds. No inhibition of basal FFA release was seen in control animals. From these experiments, it is concluded that chickens mobilize FFA extensively under cold-exposure and that this stimulated lipolysis is inhibited by PGE1.

405 REGULATION OF PLASMA FREE FATTY ACID METABOLISM DURING INTENSE EXERCISE

1994 ◽  
Vol 26 (Supplement) ◽  
pp. S72
Author(s):  
C. A. Raguso ◽  
A. R. Coggan ◽  
L. S. Sidossis ◽  
A. Gastaldelli ◽  
R. R. Wolfe
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Plasma Free Fatty Acid ◽  
Intense Exercise ◽  
Free Fatty Acid Metabolism
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