Neurotoxic destruction of the serotoninergic innervation of the rat subcommissural organ is followed by reinnervation through collateral sprouting of non-monoaminergic neurons

1979 ◽  
Vol 8 (4) ◽  
pp. 469-480 ◽  
Author(s):  
Leif Wiklund ◽  
Kjeld M�llg�rd
Keyword(s):  
Subcommissural Organ ◽  
Collateral Sprouting ◽  
Monoaminergic Neurons ◽  
Serotoninergic Innervation

Origin and influence of the serotoninergic innervation of the subcommissural organ in the rat

Neuroscience ◽  
1983 ◽  
Vol 10 (2) ◽  
pp. 411-423 ◽  
Author(s):  
L. Léger ◽  
A. Degueurce ◽  
J.J. Lundberg ◽  
J.F. Pujol ◽  
K. Møllgård
Keyword(s):  
Subcommissural Organ ◽  
Serotoninergic Innervation

Analysis and quantification of the secretory products of the subcommissural organ by use of monoclonal antibodies

2001 ◽  
Vol 52 (5) ◽  
pp. 510-519 ◽  
Author(s):  
Pedro Fern�ndez-Llebrez ◽  
Elena Miranda ◽  
Guillermo Estivill-Torr�s ◽  
Manuel Cifuentes ◽  
Jesus M. Grondona ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Subcommissural Organ ◽  
Secretory Products

scholarly journals Neuropathology of the Brainstem to Mechanistically Understand and to Treat Alzheimer’s Disease

2021 ◽  
Vol 10 (8) ◽  
pp. 1555
Author(s):  
Ágoston Patthy ◽  
János Murai ◽  
János Hanics ◽  
Anna Pintér ◽  
Péter Zahola ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cortical Neurons ◽  
Molecular Mechanisms ◽  
Neurodegenerative Disorder ◽  
Brain Structures ◽  
Specific Information ◽  
Cellular Mechanisms ◽  
Monoaminergic System ◽  
Monoaminergic Neurons

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder as yet without effective therapy. Symptoms of this disorder typically reflect cortical malfunction with local neurohistopathology, which biased investigators to search for focal triggers and molecular mechanisms. Cortex, however, receives massive afferents from caudal brain structures, which do not only convey specific information but powerfully tune ensemble activity. Moreover, there is evidence that the start of AD is subcortical. The brainstem harbors monoamine systems, which establish a dense innervation in both allo- and neocortex. Monoaminergic synapses can co-release neuropeptides either by precisely terminating on cortical neurons or, when being “en passant”, can instigate local volume transmission. Especially due to its early damage, malfunction of the ascending monoaminergic system emerges as an early sign and possible trigger of AD. This review summarizes the involvement and cascaded impairment of brainstem monoaminergic neurons in AD and discusses cellular mechanisms that lead to their dysfunction. We highlight the significance and therapeutic challenges of transmitter co-release in ascending activating system, describe the role and changes of local connections and distant afferents of brainstem nuclei in AD, and summon the rapidly increasing diagnostic window during the last few years.

Isograft and xenograft of the subcommissural organ into the lateral ventricle of the rat and the formation of Reissner's fiber

1999 ◽  
Vol 296 (3) ◽  
pp. 457-469 ◽  
Author(s):  
S. Rodríguez ◽  
E. H. Navarrete ◽  
K. Vio ◽  
C. González ◽  
K. Schöbitz ◽  
...  
Keyword(s):  
Lateral Ventricle ◽  
Subcommissural Organ ◽  
Reissner's Fiber ◽  
Reissner’S Fiber

HISTOLOGY AND HISTOCHEMISTRY OF THE PINEAL ORGAN IN THE SOCKEYE SALMON, ONCORHYNCHUS NERKA WALBAUM

1967 ◽  
Vol 45 (1) ◽  
pp. 117-126 ◽  
Author(s):  
M. A. Hafeez ◽  
P. Ford
Keyword(s):  
Sockeye Salmon ◽  
Pineal Organ ◽  
Subcommissural Organ ◽  
Sensory Nerve ◽  
Nerve Fibers ◽  
Supporting Cells ◽  
Dependent Behavior ◽  
Aldehyde Fuchsin ◽  
Pineal Nerve ◽  
The Brain

The morphohistology and some histochemical aspects of the pineal organ in the sockeye salmon were studied. The distal part of the organ lies in a pineal fossa in the cranial roof. Photosensory cells and two kinds of ependymal supporting cells are present throughout its epithelium, which is entirely devoid of either melanin or lipofuchsin. Besides sensory nerve fibers, efferent end-loops are present on the photosensory as well as the supporting cells. The dorsal pineal nerve tract probably contains both sensory and efferent fibers. The apocrine secretion of sensory as well as some supporting cells is probably associated with either the maintenance of a constant chemical composition of the cerebrospinal fluid or with supply of certain chemical substances to the brain tissue. The secretion in the pineal and the subcommissural organ consists of glycogen, mucopolysaccharides, mucoproteins, and aldehyde fuchsin positive granules.It is proposed that the pineal organ is photosensory as well as secretory and that its photosensitivity might be of some significance in the light-dependent behavior of this species in terms of intensity detection.

scholarly journals Neuregulin-1 promotes functional improvement by enhancing collateral sprouting in SOD1G93A ALS mice and after partial muscle denervation

2016 ◽  
Vol 95 ◽  
pp. 168-178 ◽  
Author(s):  
Renzo Mancuso ◽  
Anna Martínez-Muriana ◽  
Tatiana Leiva ◽  
David Gregorio ◽  
Lorena Ariza ◽  
...  
Keyword(s):  
Functional Improvement ◽  
Muscle Denervation ◽  
Neuregulin 1 ◽  
Collateral Sprouting

Radioautographic evidence for an innervation of the subcommissural organ by GABA-containing nerve fibres

1981 ◽  
Vol 10 (3) ◽  
pp. 411-424 ◽  
Author(s):  
H. Gamrani ◽  
M. F. Belin ◽  
M. Aguera ◽  
A. Calas ◽  
J. F. Pujol
Keyword(s):  
Subcommissural Organ ◽  
Nerve Fibres
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