Fine structure of the afferent synapse and gap junctions on the sensory hair cell in the saccular macula of goldfish: A freeze-fracture study

1980 ◽  
Vol 9 (6) ◽  
pp. 845-860 ◽  
Author(s):  
Kiyoshi Hama
Keyword(s):  
Fine Structure ◽  
Gap Junctions ◽  
Hair Cell ◽  
Freeze Fracture ◽  
Sensory Hair ◽  
Sensory Hair Cell ◽  
Afferent Synapse ◽  
Fracture Study

scholarly journals A missense mutation in DCDC2 causes human recessive deafness DFNB66, likely by interfering with sensory hair cell and supporting cell cilia length regulation

2015 ◽  
Vol 24 (9) ◽  
pp. 2482-2491 ◽  
Author(s):  
M'hamed Grati ◽  
Imen Chakchouk ◽  
Qi Ma ◽  
Mariem Bensaid ◽  
Alexandra Desmidt ◽  
...  
Keyword(s):  
Hair Cell ◽  
Missense Mutation ◽  
Supporting Cell ◽  
Sensory Hair ◽  
Sensory Hair Cell ◽  
Length Regulation

scholarly journals Dimethyl Sulfoxide (DMSO) Exacerbates Cisplatin-induced Sensory Hair Cell Death in Zebrafish (Danio rerio)

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e55359 ◽  
Author(s):  
Phillip M. Uribe ◽  
Melissa A. Mueller ◽  
Julia S. Gleichman ◽  
Matthew D. Kramer ◽  
Qi Wang ◽  
...  
Keyword(s):  
Cell Death ◽  
Hair Cell ◽  
Dimethyl Sulfoxide ◽  
Danio Rerio ◽  
Sensory Hair ◽  
Hair Cell Death ◽  
Sensory Hair Cell

scholarly journals Oral Antioxidant Vitamins and Magnesium Limit Noise-Induced Hearing Loss by Promoting Sensory Hair Cell Survival: Role of Antioxidant Enzymes and Apoptosis Genes

Antioxidants ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1177
Author(s):  
Juan C. Alvarado ◽  
Verónica Fuentes-Santamaría ◽  
Pedro Melgar-Rojas ◽  
María C. Gabaldón-Ull ◽  
José J. Cabanes-Sanchis ◽  
...  
Keyword(s):  
Cell Death ◽  
Hearing Loss ◽  
Antioxidant Enzymes ◽  
Oral Administration ◽  
Hair Cell ◽  
Cell Survival ◽  
Sensory Cell ◽  
Auditory Function ◽  
Sensory Hair ◽  
Sensory Hair Cell

Noise induces oxidative stress in the cochlea followed by sensory cell death and hearing loss. The proof of principle that injections of antioxidant vitamins and Mg2+ prevent noise-induced hearing loss (NIHL) has been established. However, effectiveness of oral administration remains controversial and otoprotection mechanisms are unclear. Using auditory evoked potentials, quantitative PCR, and immunocytochemistry, we explored effects of oral administration of vitamins A, C, E, and Mg2+ (ACEMg) on auditory function and sensory cell survival following NIHL in rats. Oral ACEMg reduced auditory thresholds shifts after NIHL. Improved auditory function correlated with increased survival of sensory outer hair cells. In parallel, oral ACEMg modulated the expression timeline of antioxidant enzymes in the cochlea after NIHL. There was increased expression of glutathione peroxidase-1 and catalase at 1 and 10 days, respectively. Also, pro-apoptotic caspase-3 and Bax levels were diminished in ACEMg-treated rats, at 10 and 30 days, respectively, following noise overstimulation, whereas, at day 10 after noise exposure, the levels of anti-apoptotic Bcl-2, were significantly increased. Therefore, oral ACEMg improves auditory function by limiting sensory hair cell death in the auditory receptor following NIHL. Regulation of the expression of antioxidant enzymes and apoptosis-related proteins in cochlear structures is involved in such an otoprotective mechanism.

scholarly journals A freeze-fracture study on the developing satellite cells of spinal ganglia in the chick embryo

1988 ◽  
Vol 46 (1) ◽  
pp. 6-9
Author(s):  
Claudio A. Ferraz de Carvalho ◽  
Ciro F. da Silva
Keyword(s):  
Chick Embryo ◽  
Gap Junctions ◽  
Tight Junctions ◽  
Small Groups ◽  
Satellite Cells ◽  
Freeze Fracture ◽  
Fracture Analysis ◽  
Spinal Ganglia ◽  
Pinocytotic Vesicles ◽  
Fracture Study

A freeze-fracture analysis of the satellite cells of spinal ganglia of the chick embryo was performed in 8 successive stages of development, from the 5th incubation day to hatching. The characteristic laminar disposition of the cells were first observed on the 7th day. Tight junctions were found at the 20th incubation day. Small groups or irregular aggregates of particles, but not gap junctions, were described on the 7th and 8th days. Pinocytotic vesicles were pointed out in the different stages considered.

scholarly journals Basic helix–loop–helix gene Hes6 delineates the sensory hair cell lineage in the inner ear

2006 ◽  
Vol 235 (6) ◽  
pp. 1689-1700 ◽  
Author(s):  
Dong Qian ◽  
Kristen Radde-Gallwitz ◽  
Michael Kelly ◽  
Björn Tyrberg ◽  
Jaesang Kim ◽  
...  
Keyword(s):  
Hair Cell ◽  
Inner Ear ◽  
Cell Lineage ◽  
Sensory Hair ◽  
Basic Helix Loop Helix ◽  
Helix Loop Helix ◽  
Sensory Hair Cell
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