Chemical stability, biological activity and cellular uptake of a cisplatin analogue having a 1,2-diarylethyleneamine ligand in cultures of human breast cancer cells

1995 ◽  
Vol 121 (1) ◽  
pp. 31-38 ◽  
Author(s):  
Angela M. Otto ◽  
Nicole A. Kratochwil ◽  
Hella Eggers ◽  
Patrick J. Bednarski
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Chemical Stability ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast

scholarly journals Synthesis, Retention, and Biological Activity of Methotrexate Polyglutamates in Cultured Human Breast Cancer Cells

1982 ◽  
Vol 70 (2) ◽  
pp. 351-360 ◽  
Author(s):  
Jacques Jolivet ◽  
Richard L. Schilsky ◽  
Brenda D. Bailey ◽  
James C. Drake ◽  
Bruce A. Chabner
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Methotrexate Polyglutamates

scholarly journals Uptake of Photosensitizer 2-Devinyl-2-(1-methoxylethyl) Chlorinfin Human Breast Cancer Cells: A Diffusion Kinetics Study

2012 ◽  
Vol 2012 ◽  
pp. 1-8
Author(s):  
Ping Chen ◽  
Feng Zhang ◽  
Lei Zhang ◽  
Song-Cheng Mao ◽  
Lie Lin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Diffusion Kinetics ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Kinetics Of ◽  
Mcf 7

The kinetics of photosensitizer 2-devinyl-2-(1-methoxylethyl) chlorinf(CPD4) uptake in MCF-7 human breast cancer cells is described by a diffusion kinetics model and experimentally investigated using laser scanning confocal microscopy (LSCM). CPD4 permeated into MCF-7 cells with increasing incubation time, which was followed by its binding to cell organelles. Subcellular distribution study revealed that CPD4 was primarily localized on the mitochondria and membranes, supporting that the mode of transmembrane transport was diffusion. A kinetics model describing CPD4 passing through the plasma membrane of MCF-7 cells was proposed based on Fick's first law of diffusion. The kinetics of cellular uptake of CPD4 was studied by three-dimensional LSCM. By fitting the experimental data using the above model, important cellular uptake and distribution parameters were obtained, which are of clinical significance in photodynamic therapy.

scholarly journals Autoinduction of Retinoic Acid Metabolism to Polar Derivatives with Decreased Biological Activity in Retinoic Acid-sensitive, but Not in Retinoic Acid-resistant Human Breast Cancer Cells

1997 ◽  
Vol 272 (29) ◽  
pp. 17921-17928 ◽  
Author(s):  
Bas-jan M. van der Leede ◽  
Christina E. van den Brink ◽  
Wilhelmus W. M. Pijnappel ◽  
Edwin Sonneveld ◽  
Paul T. van der Saag ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Retinoic Acid ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Acid Metabolism ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Polar Derivatives
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