Receptor binding of corticosterone in monoaminergic structures of the brain of rats after neonatal blockade of the hypophyseoadrenal system

1991 ◽  
Vol 21 (5) ◽  
pp. 387-390
Author(s):  
I. A. Garina ◽  
V. V. Rakitskaya ◽  
V. G. Shalyapina
Keyword(s):  
Receptor Binding ◽  
Monoaminergic Structures ◽  
The Brain

Quantification of central benzodiazepine receptor binding potential in the brain with 123I-iomazenil SPECT

1993 ◽  
Vol 14 (8) ◽  
pp. 634-643 ◽  
Author(s):  
N. P.L.G. VERHOEFF ◽  
B. ERBAS ◽  
O. KAPUCU ◽  
E. BUSEMANN SOKOLE ◽  
H. BLOK ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Benzodiazepine Receptor ◽  
Binding Potential ◽  
Central Benzodiazepine Receptor ◽  
The Brain

Increases in brain and cardiac AT1 receptor and ACE densities after myocardial infarct in rats

2004 ◽  
Vol 286 (5) ◽  
pp. H1665-H1671 ◽  
Author(s):  
Junhui Tan ◽  
Hao Wang ◽  
Frans H. H. Leenen
Keyword(s):  
Paraventricular Nucleus ◽  
Receptor Binding ◽  
Myocardial Infarct ◽  
Subfornical Organ ◽  
Preoptic Nucleus ◽  
Fab Fragments ◽  
Intracerebroventricular Infusion ◽  
Organum Vasculosum Laminae Terminalis ◽  
Organum Vasculosum ◽  
The Brain

In the brain, ouabain-like compounds (OLC) and the reninangiotensin system (RAS) contribute to sympathetic hyperactivity in rats after myocardial infarction (MI). This study aimed to evaluate changes in components of the central vs. the peripheral RAS. Angiotensin-converting enzyme (ACE) and angiotensin type 1 (AT1) receptor binding densities were determined by measuring 125I-labeled 351A and 125I-labeled ANG II binding 4 and 8 wk after MI. In the brain, ACE and AT1 receptor binding increased 8–15% in the subfornical organ, 14–22% in the organum vasculosum laminae terminalis, 20–34% in the paraventricular nucleus, and 13–15% in the median preoptic nucleus. In the heart, the greatest increase in ACE and AT1 receptor binding occurred at the infarct scar (∼10-fold) and the least in the right ventricle (2-fold). In kidneys, ACE and AT1 receptor binding decreased 10–15%. After intracerebroventricular infusion of Fab fragments to block brain OLC from 0.5 to 4 wk after MI, increases in ACE and AT1 receptors in the subfornical organ, organum vasculosum laminae terminalis, paraventricular nucleus, and medial preoptic nucleus were markedly inhibited, and ACE and AT1 receptor densities in the heart increased less (6-fold in the infarct scar). In kidneys, decreases in ACE and AT1 receptor binding were absent after treatment with Fab fragments. These results demonstrate that ACE and AT1 receptor binding densities increase not only in the heart but also in relevant areas of the brain of rats after MI. Brain OLC appears to play a major role in activation of brain RAS in rats after MI and, to a modest degree, in activation of the cardiac RAS.

scholarly journals Vasopressin and Pair-Bond Formation: Genes to Brain to Behavior

Physiology ◽  
2006 ◽  
Vol 21 (2) ◽  
pp. 146-152 ◽  
Author(s):  
Hemanth P. Nair ◽  
Larry J. Young
Keyword(s):  
Social Behavior ◽  
Receptor Binding ◽  
Social Bonds ◽  
Receptor Gene ◽  
Bond Formation ◽  
Pair Bond ◽  
Vasopressin Receptor ◽  
Microsatellite Sequence ◽  
Microtine Rodents ◽  
The Brain

Microtine rodents provide an excellent model for the study of the neurobiology of social bonds. In this review, we discuss how the presence of a microsatellite sequence in the prairie vole vasopressin receptor gene may determine vasopressin receptor binding patterns in the brain and how these patterns may in turn affect social behavior.

Correlation of human cold pressor pain responses with 5-HT1A receptor binding in the brain

2007 ◽  
Vol 1172 ◽  
pp. 21-31 ◽  
Author(s):  
Ilkka K. Martikainen ◽  
Jussi Hirvonen ◽  
Jaana Kajander ◽  
Nora Hagelberg ◽  
Heikki Mansikka ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Cold Pressor ◽  
Cold Pressor Pain ◽  
The Brain ◽  
Pain Responses

scholarly journals Neonatal Clonazepam Administration Induced Long-Lasting Changes in GABAA and GABAB Receptors

2020 ◽  
Vol 21 (9) ◽  
pp. 3184
Author(s):  
Hana Kubová ◽  
Zdeňka Bendová ◽  
Simona Moravcová ◽  
Dominika Pačesová ◽  
Luisa Rocha ◽  
...  
Keyword(s):  
Gabaa Receptor ◽  
Receptor Binding ◽  
Brain Structure ◽  
Gabab Receptor ◽  
Brain Structures ◽  
Emotional Behavior ◽  
Gabab Receptors ◽  
Behavioral Impairment ◽  
Almost All ◽  
The Brain

Benzodiazepines (BZDs) are widely used in patients of all ages. Unlike adults, neonatal animals treated with BZDs exhibit a variety of behavioral deficits later in life; however, the mechanisms underlying these deficits are poorly understood. This study aims to examine whether administration of clonazepam (CZP; 1 mg/kg/day) in 7–11-day-old rats affects Gama aminobutyric acid (GABA)ergic receptors in both the short and long terms. Using RT-PCR and quantitative autoradiography, we examined the expression of the selected GABAA receptor subunits (α1, α2, α4, γ2, and δ) and the GABAB B2 subunit, and GABAA, benzodiazepine, and GABAB receptor binding 48 h, 1 week, and 2 months after treatment discontinuation. Within one week after CZP cessation, the expression of the α2 subunit was upregulated, whereas that of the δ subunit was downregulated in both the hippocampus and cortex. In the hippocampus, the α4 subunit was downregulated after the 2-month interval. Changes in receptor binding were highly dependent on the receptor type, the interval after treatment cessation, and the brain structure. GABAA receptor binding was increased in almost all of the brain structures after the 48-h interval. BZD-binding was decreased in many brain structures involved in the neuronal networks associated with emotional behavior, anxiety, and cognitive functions after the 2-month interval. Binding of the GABAB receptors changed depending on the interval and brain structure. Overall, the described changes may affect both synaptic development and functioning and may potentially cause behavioral impairment.

scholarly journals Application of (125I)(S)-5-Iodonicotine, a New Radioiodinated Ligand, in the Assay of Nicotinic Acetylcholine Receptor Binding in the Brain.

1995 ◽  
Vol 18 (11) ◽  
pp. 1463-1466 ◽  
Author(s):  
Hideo SAJI ◽  
Akira WATANABE ◽  
Yasushi KIYONO ◽  
Yasuhiro MAGATA ◽  
Yasuhiko IIDA ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Receptor Binding ◽  
Nicotinic Acetylcholine ◽  
The Brain
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