Antiproliferative activity of liposomal epirubicin on experimental human gliomas in vitro and in vivo after intratumoral/interstitial application

1995 ◽  
Vol 121 (3) ◽  
pp. 164-168 ◽  
Author(s):  
D. K. Todorov ◽  
S. S. Ninjo ◽  
W. J. Zeller
Keyword(s):  
Antiproliferative Activity ◽  
Human Gliomas

In vitro and in vivo antiproliferative activity of arucanolide isolated from Calea pinnatifida

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
G Marchetti ◽  
K Silva ◽  
A Ruiz ◽  
I Sousa ◽  
S Tinti ◽  
...  
Keyword(s):  
Antiproliferative Activity

scholarly journals Design, Synthesis, Molecular Modeling and Antitumor Evaluation of Novel Indolyl-Pyrimidine Derivatives with EGFR Inhibitory Activity

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1838
Author(s):  
Naglaa M. Ahmed ◽  
Mahmoud M. Youns ◽  
Moustafa K. Soltan ◽  
Ahmed M. Said
Keyword(s):  
Molecular Modeling ◽  
Antitumor Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Antiproliferative Activity ◽  
Antitumor Agents ◽  
Cancer Cell Lines ◽  
Normal Cells

Scaffolds hybridization is a well-known drug design strategy for antitumor agents. Herein, series of novel indolyl-pyrimidine hybrids were synthesized and evaluated in vitro and in vivo for their antitumor activity. The in vitro antiproliferative activity of all compounds was obtained against MCF-7, HepG2, and HCT-116 cancer cell lines, as well as against WI38 normal cells using the resazurin assay. Compounds 1–4 showed broad spectrum cytotoxic activity against all these cancer cell lines compared to normal cells. Compound 4g showed potent antiproliferative activity against these cell lines (IC50 = 5.1, 5.02, and 6.6 μM, respectively) comparable to the standard treatment (5-FU and erlotinib). In addition, the most promising group of compounds was further evaluated for their in vivo antitumor efficacy against EAC tumor bearing mice. Notably, compound 4g showed the most potent in vivo antitumor activity. The most active compounds were evaluated for their EGFR inhibitory (range 53–79 %) activity. Compound 4g was found to be the most active compound against EGFR (IC50 = 0.25 µM) showing equipotency as the reference treatment (erlotinib). Molecular modeling study was performed on compound 4g revealed a proper binding of this compound inside the EGFR active site comparable to erlotinib. The data suggest that compound 4g could be used as a potential anticancer agent.

scholarly journals Antiproliferative activity of thiazole and oxazole derivatives: A systematic review of in vitro and in vivo studies

2021 ◽  
Vol 138 ◽  
pp. 111495
Author(s):  
Nancy Y. Guerrero-Pepinosa ◽  
María C. Cardona-Trujillo ◽  
Sandra C. Garzón-Castaño ◽  
Luz Angela Veloza ◽  
Juan C. Sepúlveda-Arias
Keyword(s):  
Systematic Review ◽  
Antiproliferative Activity ◽  
In Vivo Studies ◽  
Oxazole Derivatives

Expression of REST4 in human gliomas in vivo and influence of pioglitazone on REST in vitro

2015 ◽  
Vol 463 (4) ◽  
pp. 504-509 ◽  
Author(s):  
Huan Ren ◽  
Zhangfeng Gao ◽  
Nayiyuan Wu ◽  
Liu Zeng ◽  
Xinyue Tang ◽  
...  
Keyword(s):  
Human Gliomas

scholarly journals Anticancer and Anti-Inflammatory Activities of a Standardized Dichloromethane Extract fromPiper umbellatumL. Leaves

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Leilane Hespporte Iwamoto ◽  
Débora Barbosa Vendramini-Costa ◽  
Paula Araújo Monteiro ◽  
Ana Lúcia Tasca Gois Ruiz ◽  
Ilza Maria de Oliveira Sousa ◽  
...  
Keyword(s):  
Solid Tumor ◽  
Anticancer Agents ◽  
Antiproliferative Activity ◽  
Tumor Model ◽  
Oral Route ◽  
Paw Edema ◽  
Anti Inflammatory ◽  
Cancer And Inflammation

Despite the advances in anticancer drug discovery field, the worldwide cancer incidence is remarkable, highlighting the need for new therapies focusing on both cancer cell and its microenvironment. The tumor microenvironment offers multiple targets for cancer therapy, including inflammation. Nowadays, almost 75% of the anticancer agents used in chemotherapy are derived from natural products, and plants are an important source of new promising therapies. Continuing our research onPiper umbellatumspecies, here we describe the anticancer (in vitroantiproliferative activity andin vivoEhrlich solid tumor model) and anti-inflammatory (carrageenan-induced paw edema and peritonitis models) activities of a standardized dichloromethane extract (SDE) fromP. umbellatumleaves, containing 23.9% of 4-nerolidylcatechol. SDE showedin vitroandin vivoantiproliferative activity, reducing Ehrlich solid tumor growth by 38.7 and 52.2% when doses of 200 and 400 mg/kg, respectively, were administered daily by oral route. Daily treatments did not produce signals of toxicity. SDE also reduced paw edema and leukocyte migration on carrageenan-induced inflammation models, suggesting that the anticancer activity of SDE fromPiper umbellatumleaves could involve antiproliferative and anti-inflammatory effects. These findings highlightP. umbellatumas a source of compounds against cancer and inflammation.

In Vitro and In Vivo Efficacy of a New Immunotoxin, 5E9-RNAse, in the Treatment of Human Gliomas

Neurosurgery ◽  
1992 ◽  
Vol 30 (5) ◽  
pp. 804-805
Author(s):  
O. Ilercil ◽  
D. Laske ◽  
D. Newton ◽  
S. Rybak ◽  
E. Oldfield ◽  
...  
Keyword(s):  
Human Gliomas ◽  
In Vivo Efficacy

scholarly journals Deferasirox, a novel oral iron chelator, shows antiproliferative activity against pancreatic cancer in vitro and in vivo

BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Hirofumi Harima ◽  
Seiji Kaino ◽  
Taro Takami ◽  
Shuhei Shinoda ◽  
Toshihiko Matsumoto ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Antiproliferative Activity ◽  
Iron Chelator ◽  
Oral Iron ◽  
Oral Iron Chelator
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