Antitumor effect induced by granulocyte/macrophage-colony-stimulating factor gene-modified tumor vaccination: Comparison of adenovirus- and retrovirus-mediated genetic transduction

1995 ◽  
Vol 121 (9-10) ◽  
pp. 587-592 ◽  
Author(s):  
Junko Abe ◽  
Hiroaki Wakimoto ◽  
Yoko Yoshida ◽  
Masaru Aoyagi ◽  
Kimiyoshi Hirakawa ◽  
...  
Keyword(s):  
Antitumor Effect ◽  
Colony Stimulating Factor ◽  
Factor Gene ◽  
Tumor Vaccination ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

scholarly journals Testing of Experimental Compounds in a Relapse Model of Tuberculosis Using Granulocyte-Macrophage Colony-Stimulating Factor Gene-Disrupted Mice

2008 ◽  
Vol 53 (1) ◽  
pp. 306-308 ◽  
Author(s):  
Lisa K. Woolhiser ◽  
Donald R. Hoff ◽  
Karen S. Marietta ◽  
Ian M. Orme ◽  
Anne J. Lenaerts
Keyword(s):  
Subsequent Treatment ◽  
In Vivo Model ◽  
Disease Relapse ◽  
Colony Stimulating Factor ◽  
Factor Gene ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor ◽  
Number Of Bacteria

ABSTRACT This study describes an in vivo model for evaluating the sterilizing activity of compounds against persisting Mycobacterium tuberculosis. The initial treatment with isoniazid and rifampin in granulocyte-macrophage colony-stimulating factor gene-disrupted mice reduced the number of bacteria more than 99% within 3 weeks. A subsequent treatment with individual drugs was performed to assess their activity on the 1% of remaining bacilli and disease relapse.

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