State of rat adrenal glucocorticoid function in pinealectomy

1987 ◽  
Vol 17 (5) ◽  
pp. 446-448
Author(s):  
V. A. Kosykh ◽  
T. V. Lasukova ◽  
Yu. G. Kozlova
Keyword(s):  
Adrenal Glucocorticoid

Assessment of adrenal glucocorticoid function

1998 ◽  
Vol 104 (1) ◽  
pp. 61-71 ◽  
Author(s):  
Stefan Hasinski
Keyword(s):  
Adrenal Glucocorticoid

scholarly journals Extra-adrenal glucocorticoid synthesis at epithelial barriers

2019 ◽  
Vol 20 (8) ◽  
pp. 627-640 ◽  
Author(s):  
Truong San Phan ◽  
Verena M. Merk ◽  
Thomas Brunner
Keyword(s):  
Epithelial Barriers ◽  
Adrenal Glucocorticoid

Glucocorticoid Hormones in Stress: Physiological and Pharmacological Actions

Physiology ◽  
1986 ◽  
Vol 1 (2) ◽  
pp. 69-72 ◽  
Author(s):  
A Munck ◽  
PM Guyre
Keyword(s):  
Immune Responses ◽  
Defense Mechanisms ◽  
Pharmacological Effects ◽  
Glucocorticoid Hormones ◽  
Physiological Functions ◽  
Half Century ◽  
Normal Functions ◽  
Fundamental Distinction ◽  
Simple Question ◽  
Adrenal Glucocorticoid

What are the normal functions of the adrenal glucocorticoid hormones? This seemingly simple question has not yet any simple agreed-on answer. In the half-century since the glucocorticoids were distinguished from other cortical steroids, the question of their physiological functions has generated much inconclusive debate. Likewise, questions of their role in disease and therapy lack definitive answers. The authors propose that there is no fundamental distinction between the physiological and pharmacological effects of glucocorticoids and that their inhibitory actions on inflammatory and immune responses are concerned with modulating the body's defense mechanisms.

scholarly journals The transcriptional regulating protein of 132 kDa (TReP-132) differentially influences steroidogenic pathways in human adrenal NCI-H295 cells

2004 ◽  
Vol 32 (2) ◽  
pp. 557-569 ◽  
Author(s):  
F Gizard ◽  
E Teissier ◽  
I Dufort ◽  
G Luc ◽  
V Luu-The ◽  
...  
Keyword(s):  
Mrna Levels ◽  
Steroid Biosynthesis ◽  
Steroidogenic Factor 1 ◽  
Transcript Levels ◽  
Adrenal Steroid ◽  
Physiological Processes ◽  
Estrogen Production ◽  
Coordinated Expression ◽  
Species Specific ◽  
Adrenal Glucocorticoid

Steroid hormones synthesized from cholesterol in the adrenal gland are important regulators of many physiological processes. It is now well documented that the expression of many genes required for steroid biosynthesis is dependent on the coordinated expression of the nuclear receptor steroidogenic factor-1 (SF-1). However, transcriptional mechanisms underlying the species-specific, developmentally programmed and hormone-dependent modulation of the adrenal steroid pathways remain to be elucidated. Recently, we demonstrated that the transcriptional regulating protein of 132 kDa (TReP-132) acts as a coactivator of SF-1 to regulate human P450scc gene transcription in human adrenal NCI-H295 cells. The present study shows that overexpression of TReP-132 increases the level of active steroids produced in NCI-H295 cells. The conversion of pregnenolone to downstream steroids following TReP-132 expression showed increased levels of glucocorticoids, C(19) steroids and estrogens. Correlating with these data, TReP-132 increases P450c17 activities via the induction of transcript levels and promoter activity of the P450c17 gene, an effect that is enhanced in the presence of cAMP or SF-1. In addition, P450aro activity and mRNA levels are highly induced by TReP-132, whereas 3beta-hydroxysteroid dehydrogenase type II and P450c11aldo transcript levels are only slightly modulated. Taken together, these results demonstrate that TReP-132 is a trans-acting factor of genes involved in adrenal glucocorticoid, C(19) steroid and estrogen production.

A local immuno-endocrine interaction may mediate rat adrenal glucocorticoid response to bacterial endotoxins

Life Sciences ◽  
1998 ◽  
Vol 62 (19) ◽  
pp. 1783-1787 ◽  
Author(s):  
Giuseppina Mazzocchi ◽  
Giuseppe Gottardo ◽  
Gastone G. Nussdorfer
Keyword(s):  
Bacterial Endotoxins ◽  
Glucocorticoid Response ◽  
Adrenal Glucocorticoid

scholarly journals Evidence that Increased Adrenal Glucocorticoid Release During Superovulation does not Impair Gonadal Responses in Crossbred Thai Dairy Cows

2020 ◽  
Vol 19 (4) ◽  
Author(s):  
Jaruwan Khonmee ◽  
◽  
Jureerat Sumretprasong ◽  
Janine L. Brown ◽  
Kamraitip Lokham ◽  
...  
Keyword(s):  
Dairy Cows ◽  
Adrenal Glucocorticoid

scholarly journals The state of steroidogenesis in the adrenal glands and gonads in patients with polycystic ovary with inhibition of gonadotropic function

2019 ◽  
Vol 45 (1) ◽  
pp. 34-37
Author(s):  
A. D. Dobracheva ◽  
N. P. Goncharov ◽  
T. N. Todua ◽  
I. D. Nizharadze
Keyword(s):  
Gnrh Agonist ◽  
Adrenal Glands ◽  
Polycystic Ovary ◽  
Polycystic Ovaries ◽  
Adrenal Androgen ◽  
Gonadotropic Function ◽  
Adrenal Steroidogenesis ◽  
Secretion Inhibition ◽  
Gonadotropic Hormones ◽  
Adrenal Glucocorticoid

Relationships between secretion of pituitary gonadotropic hormones, adrenal glucocorticoid and androgenic function, and ovarian steroid production were studied in 14 patients with the polycystic ovaries syndrome (POS) under conditions of suppressed endogenous gonadotropic secretion, which was induced by tonic administration of busereline, a GnRH agonist. The bRH/iRH ratio is not changed in POS patients under conditions of suppressed gonadotropic secretion. Inhibition of gonadotropic secretion leads to decrease of estrogen secretion in the ovaries and does not affect the adrenal glucocorticoid function. Activation of adrenal androgen production by the delta-5 pathway was observed in 57% patients under conditions of gonadotroph inhibition. Three months after busereline was discontinued, adrenal steroidogenesis normalized. The results permit a conclusion that prolonged inhibition of gonadotropic secretion with GnRH agonist does not change the bLH/iLH ratio but can lead to activation of adrenal androgen production in part of patients with POS.

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