State of the effect of long-term administration of thyrotrophin releasing hormone to rats on the posterior lobe of the pituitary

1986 ◽  
Vol 16 (2) ◽  
pp. 169-172
Author(s):  
I. A. Krasnovskaya ◽  
T. V. Tavrovskaya
Keyword(s):  
Posterior Lobe ◽  
Thyrotrophin Releasing Hormone ◽  
Releasing Hormone ◽  
Term Administration

scholarly journals PET Study in a Patient with Spinocerebellar Degeneration before and after Long-Term Administration of Thyrotropin Releasing Hormone

1996 ◽  
Vol 9 (3-4) ◽  
pp. 171-175
Author(s):  
H. Tanji ◽  
H. Nagasawa ◽  
T. Hayashi ◽  
H. Onodera ◽  
T. Fujiwara ◽  
...  
Keyword(s):  
Thyrotropin Releasing Hormone ◽  
Spinocerebellar Degeneration ◽  
Chronic Effect ◽  
Releasing Hormone ◽  
Positron Emission ◽  
Significant Difference ◽  
Before And After ◽  
Term Administration ◽  
The Central Nervous System

We studied the chronic effect of thyrotropin releasing hormone (TRH) in a patient with spinocerebellar degeneration by measuring cerebral metabolic rate for glucose (CMRG1c) using 2-[18F]fluoro-2-deoxy-D-glucose (18FDG) and positron emission tomography (PET). A 56-year-old female, who had suffered from progressive ataxia for 2 years, was treated by intravenous administration of 2 mg TRH for 3 weeks, and CMRG1c of the brain was measured before and after treatment. CMRG1c was markedly decreased in the cerebellum and there was no significant difference before and after the treatment, i.e. mean CMRG1c values were 4.92 and 4.90 mg/100 g/min, and the ratios of the cerebellum versus the frontal cortex were 0.50 and 0.51, respectively. The degree of disequilibrium of her body examined with stabilography became better by the 19th day and further improved by the 26th day after the start of TRH treatment. Based on the present study we conclude that long-term administration of TRH did not improve CMRG1c in the cerebellum, but evidently improved the sway of gravity center by stabilography. We speculate that the chronic effect of TRH was not necessarily due to an improvement of cerebellar function, because TRH receptors are widely distributed throughout the central nervous system.

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