The structures of polyinosinic acid

1973 ◽  
Vol 9 (3) ◽  
pp. 261-277 ◽  
Author(s):  
Danielle Thiele ◽  
Wilhelm Guschlbauer
Keyword(s):  
Polyinosinic Acid

Polyinosinic acid: polycytidylic acid promotes T helper type 1-specific immune responses by stimulating macrophage production of interferon-α and interleukin-12

1995 ◽  
Vol 25 (9) ◽  
pp. 2656-2660 ◽  
Author(s):  
Roberto Manetti ◽  
Francesco Annunziato ◽  
Ljiljana Tomasevic ◽  
Valeria Giannò ◽  
Paola Parronchi ◽  
...  
Keyword(s):  
Immune Responses ◽  
Interleukin 12 ◽  
Interferon Α ◽  
T Helper ◽  
Polycytidylic Acid ◽  
Polyinosinic Acid ◽  
Helper Type

scholarly journals Clearance of NH2-terminal propeptides of types I and III procollagen is a physiological function of the scavenger receptor in liver endothelial cells.

1994 ◽  
Vol 179 (2) ◽  
pp. 405-412 ◽  
Author(s):  
J Melkko ◽  
T Hellevik ◽  
L Risteli ◽  
J Risteli ◽  
B Smedsrød
Keyword(s):  
Endothelial Cells ◽  
Physiological Function ◽  
Scavenger Receptor ◽  
Alpha Phase ◽  
Maximum Diameter ◽  
Type I ◽  
Waste Products ◽  
Type I Procollagen ◽  
Polyinosinic Acid ◽  
Liver Endothelial Cells

This study was undertaken to determine the fate of circulating NH2-terminal propeptide of type I procollagen (PINP) in rats. Radiolabeled PINP showed a biphasic serum decay curve after intravenous injection. 79% of the material disappeared from the blood during the initial alpha-phase (t1/2 alpha = 0.6 min), while the remaining 21% was eliminated with a t1/2 beta of 3.3 min. The major site of uptake was the liver, 78, 1, and 21% of its radioactivity being recovered in isolated liver endothelial cells (LEC), Kupffer cells, and parenchymal cells, respectively. In LEC, fluorescently labeled PINP accumulated in small (0.1 microns) peripheral and larger (> 0.1 microns) perinuclear vesicles within 10 min at 37 degrees C after a binding pulse at 4 degrees C. These grew in size with increasing chasing time, reaching a maximum diameter of 1 microns or more after 30 min, and taking the shape of rings that were stained only along their periphery. At chase intervals exceeding 30 min, the size of the vesicles decreased, and after 60 min the stain appeared in smaller, densely stained perinuclearly located vesicles. Degradation of 125I-PINP to free smaller fragments and 125I- was significant after 30 min. Only formaldehyde-treated albumin, acetylated LDL, polyinosinic acid and NH2-terminal propeptide of type III procollagen (PIIINP) competed with PINP for uptake. These findings indicate that clearance of PINP and PIIINP, which are normal waste products generated in large quantities, is a physiological function of the scavenger receptor in LEC.

Polyinosinic acid-stabilized fluorescent silver nanoclusters for sensitive detection of biological thiols

2013 ◽  
Vol 5 (21) ◽  
pp. 6076 ◽  
Author(s):  
Dan-Ling Zhou ◽  
Hong Huang ◽  
Jie-Ning Zheng ◽  
Jian-Rong Chen ◽  
Jiu-Ju Feng ◽  
...  
Keyword(s):  
Silver Nanoclusters ◽  
Sensitive Detection ◽  
Polyinosinic Acid

X-ray fiber diffraction and model-building study of polyguanylic acid and polyinosinic acid

1975 ◽  
Vol 92 (2) ◽  
pp. 181-192 ◽  
Author(s):  
Steven B. Zimmerman ◽  
Gerson H. Cohen ◽  
David R. Davies
Keyword(s):  
Model Building ◽  
X Ray ◽  
Fiber Diffraction ◽  
Polyinosinic Acid

Single-stranded polyinosinic acid oligonucleotides trigger leukocyte production of proteins belonging to fibrinolytic and coagulation cascades

2008 ◽  
Vol 84 (3) ◽  
pp. 741-747 ◽  
Author(s):  
Fariba Zare ◽  
Mattias Magnusson ◽  
Linda Nilsson Möllers ◽  
Tao Jin ◽  
Andrej Tarkowski ◽  
...  
Keyword(s):  
Polyinosinic Acid
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