EPR of complexes of divalent copper ions with organophosphorus derivatives of 2-aminopyridine

1990 ◽  
Vol 39 (12) ◽  
pp. 2498-2504
Author(s):  
D. V. Tolkachev ◽  
A. A. Khodak ◽  
S. P. Solodovnikov ◽  
N. N. Bubnov ◽  
M. I. Kabachnik
Keyword(s):  
Copper Ions ◽  
Divalent Copper ◽  
Derivatives Of ◽  
Organophosphorus Derivatives

Synthesis of organophosphorus derivatives of lupinine and epilupinine and their interaction with cholinesterases

1987 ◽  
Vol 36 (3) ◽  
pp. 594-597
Author(s):  
D. N. Dalimov ◽  
M. B. Gafurov ◽  
G. M. Vaizburg ◽  
A. A. Abduvakhabov ◽  
N. N. Godovikov
Keyword(s):  
Derivatives Of ◽  
Organophosphorus Derivatives

scholarly journals 8-Hydroxyquinoline Glycoconjugates: Modifications in the Linker Structure and Their Effect on the Cytotoxicity of the Obtained Compounds

Molecules ◽  
2019 ◽  
Vol 24 (22) ◽  
pp. 4181 ◽  
Author(s):  
Monika Krawczyk ◽  
Gabriela Pastuch-Gawołek ◽  
Aleksandra Pluta ◽  
Karol Erfurt ◽  
Adrian Domiński ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Cytotoxic Effect ◽  
Copper Ions ◽  
Nitrogen Heterocycles ◽  
Anti Cancer ◽  
Hct 116 ◽  
Complexing Properties ◽  
Sugar Derivatives ◽  
Derivatives Of ◽  
Mcf 7

Small molecule nitrogen heterocycles are very important structures, widely used in the design of potential pharmaceuticals. Particularly, derivatives of 8-hydroxyquinoline (8-HQ) are successfully used to design promising anti-cancer agents. Conjugating 8-HQ derivatives with sugar derivatives, molecules with better bioavailability, selectivity, and solubility are obtained. In this study, 8-HQ derivatives were functionalized at the 8-OH position and connected with sugar derivatives (D-glucose or D-galactose) substituted with different groups at the anomeric position, using copper(I)-catalyzed 1,3-dipolar azide-alkyne cycloaddition (CuAAC). Glycoconjugates were tested for inhibition of the proliferation of cancer cell lines (HCT 116 and MCF-7) and inhibition of β-1,4-galactosyltransferase activity, which overexpression is associated with cancer progression. All glycoconjugates in protected form have a cytotoxic effect on cancer cells in the tested concentration range. The presence of additional amide groups in the linker structure improves the activity of glycoconjugates, probably due to the ability to chelate metal ions present in many types of cancers. The study of metal complexing properties confirmed that the obtained glycoconjugates are capable of chelating copper ions, which increases their anti-cancer potential.

ChemInform Abstract: ORGANOPHOSPHORUS DERIVATIVES OF CHLORALUREA

1979 ◽  
Vol 10 (33) ◽  
Author(s):  
K. V. NIKONOROV ◽  
E. A. GURYLEV ◽  
L. A. ANTOKHINA ◽  
E. YA. LATYPOV
Keyword(s):  
Derivatives Of ◽  
Organophosphorus Derivatives

Solvent extraction of copper ions by 3-substituted derivatives of β-diketones

2017 ◽  
Vol 53 (8) ◽  
pp. 1223-1229 ◽  
Author(s):  
Elzbieta Radzyminska-Lenarcik ◽  
Katarzyna Witt
Keyword(s):  
Solvent Extraction ◽  
Copper Ions ◽  
Derivatives Of

Synthesis of organophosphorus derivatives of lupinine and solasodine and investigation of their cholinergic activities

1992 ◽  
Vol 28 (5) ◽  
pp. 472-473 ◽  
Author(s):  
A. M. Gazaliev ◽  
S. D. Fazylov ◽  
S. N. Balitskii ◽  
R. Z. Kasenov
Keyword(s):  
Derivatives Of ◽  
Organophosphorus Derivatives

Synthesis of organophosphorus derivatives of anabasine and investigation of their cholinergic activity

1989 ◽  
Vol 25 (4) ◽  
pp. 502-503
Author(s):  
A. M. Gazaliev ◽  
M. Zh. Zhurinov ◽  
Z. Tilyabaev ◽  
D. N. Dalimov ◽  
K. D. Mukanova ◽  
...  
Keyword(s):  
Cholinergic Activity ◽  
Derivatives Of ◽  
Organophosphorus Derivatives

scholarly journals Monovalent Copper Ions Inhibit Enzymatic Systems

2021 ◽  
Author(s):  
Magal Saphier ◽  
Lea Moshkovich ◽  
Stanislav Popov ◽  
Yoram Shotland ◽  
Eldad Silberstein ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acid Phosphatase ◽  
Dna Polymerase ◽  
Restriction Enzyme ◽  
Copper Ions ◽  
Divalent Copper ◽  
Nitrogen Base ◽  
Monovalent Ions ◽  
Wide Range ◽  
Enzymatic Systems

Abstract The effect of monovalent copper ions on enzymatic systems has hardly been studied to date; this is due to the low stability of monovalent copper ions in aqueous solutions, which led to the assumption that their concentration is negligible in biological systems. However, in an anaerobic atmosphere, and in the presence of a ligand that stabilizes the monovalent copper ions over the divalent copper ions, high and stable concentrations of monovalent copper ions can be reached. Moreover, the cell cytoplasm has a substantial concentration of potential stabilizers that can explain significant concentrations of monovalent copper ions in the cytoplasm. This study demonstrates the effect of monovalent and divalent copper ions on DNA polymerase, ligaseT4 DNA, the restriction enzymes EcoP15I and EcoR I, acid phosphatase, and α and βamylase enzymes. These systems were chosen because they can be monitored under conditions necessary for maintaining a stable concentration of monovalent copper ions, and since they exhibit a wide range of dependency on ATP. Previous studies indicated that ATP interacts with monovalent and divalent copper ions and stabilizing monovalent copper ions over divalent copper ions. The results showed that monovalent copper ions dramatically inhibit DNA polymerase and acid phosphatase, inhibit ligaseT4 DNA and the restriction enzyme EcoP15I, moderately inhibit α and β amylase, and have no effect on the restriction enzyme EcoR I. From the results presented in this work, it can be concluded that the mechanism is not one of oxidative stress, even though monovalent copper ions generate reactive oxygen species (ROS). Molecular oxygen in the medium, which is supposed to increase the oxidative stress, impairs the inhibitory effect of monovalent and divalent copper ions, and the kinetics of the inhibition is not suitable for the ROS mechanism.ATP forms a complex with copper ions (di and monovalent ions, where the latter is more stable) in which the metal ion is bound both to the nitrogen base and to the oxygen charged on the phosphate groups, forming an unusually distorted complex. The results of this study indicate that these complexes have the ability to inhibit enzymatic systems that are dependent on ATP.This finding can provide an explanation for the strong antimicrobial activity of monovalent copper ions, suggesting that rapid and lethal metabolic damage is the main mechanism of monovalent copper ions’ antimicrobial effect.

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