Characterization of Schwann cells from normal nerves and from neurofibromas in the bicolour damselfish

1994 ◽  
Vol 23 (11) ◽  
pp. 668-681 ◽  
Author(s):  
Michael C. Schmale ◽  
Ken A. Gill ◽  
Saul M. Cacal ◽  
Sean D. Baribeau
Keyword(s):  
Schwann Cells

Long-term culture and characterization of human neurofibroma-derived Schwann cells

2000 ◽  
Vol 61 (5) ◽  
pp. 524-532 ◽  
Author(s):  
Thorsten Rosenbaum ◽  
Claudia Rosenbaum ◽  
Ursula Winner ◽  
Hans Werner M�ller ◽  
Hans-Gerd Lenard ◽  
...  
Keyword(s):  
Schwann Cells ◽  
Long Term Culture

Isolation and Characterization of Schwann Cells from Neurofibromatosis Type 2 Patients

1998 ◽  
Vol 5 (1) ◽  
pp. 55-64 ◽  
Author(s):  
C. Rosenbaum ◽  
L. Kluwe ◽  
V.F. Mautner ◽  
R.E. Friedrich ◽  
H.W. Müller ◽  
...  
Keyword(s):  
Schwann Cells ◽  
Neurofibromatosis Type ◽  
Neurofibromatosis Type 2 ◽  
Isolation And Characterization

scholarly journals Characterization of Glial Cell Models andIn VitroManipulation of the Neuregulin1/ErbB System

2014 ◽  
Vol 2014 ◽  
pp. 1-15 ◽  
Author(s):  
Davide Pascal ◽  
Alessia Giovannelli ◽  
Sara Gnavi ◽  
Stefan Adriaan Hoyng ◽  
Fred de Winter ◽  
...  
Keyword(s):  
Cell Line ◽  
Schwann Cells ◽  
Peripheral Nerve Regeneration ◽  
Cell Behavior ◽  
Cell Models ◽  
Migratory Activity ◽  
Pathological Conditions

The neuregulin1/ErbB system plays an important role in Schwann cell behavior both in normal and pathological conditions. Upon investigation of the expression of the neuregulin1/ErbB systemin vitro, we explored the possibility to manipulate the system in order to increase the migration of Schwann cells, that play a fundamental role in the peripheral nerve regeneration. Comparison of primary cells and stable cell lines shows that both primary olfactory bulb ensheathing cells and a corresponding cell line express ErbB1-ErbB2 and neuregulin1, and that both primary Schwann cells and a corresponding cell line express ErbB2-ErbB3, while only primary Schwann cells express neuregulin1. To interfere with the neuregulin1/ErbB system, the soluble extracellular domain of the neuregulin1 receptor ErbB4 (ecto-ErbB4) was expressedin vitroin the neuregulin1 expressing cell line, and an unexpected increase in cell motility was observed.In vitroexperiments suggest that the back signaling mediated by the transmembrane neuregulin1 plays a role in the migratory activity induced by ecto-ErbB4. These results indicate that ecto-ErbB4 could be usedin vivoas a tool to manipulate the neuregulin1/ErbB system.

Establishment and characterization of immortalized Schwann cells from murine model of Niemann-Pick disease type C (spm/spm)

2001 ◽  
Vol 6 (2) ◽  
pp. 85-94 ◽  
Author(s):  
Kazuhiko Watabe ◽  
Hiroyuki Ida ◽  
Keiko Uehara ◽  
Kiyomitsu Oyanagi ◽  
Tsuyoshi Sakamoto ◽  
...  
Keyword(s):  
Schwann Cells ◽  
Murine Model ◽  
Disease Type ◽  
Niemann Pick Disease ◽  
Type C ◽  
Niemann Pick ◽  
Pick Disease ◽  
Immortalized Schwann Cells

scholarly journals Identification and functional characterization of thromboxane A2receptors in Schwann cells

2001 ◽  
Vol 78 (3) ◽  
pp. 446-456 ◽  
Author(s):  
Naser Muja ◽  
Samuel C. Blackman ◽  
Guy C. Le Breton ◽  
George H. DeVries
Keyword(s):  
Schwann Cells ◽  
Functional Characterization

scholarly journals Purification and Characterization of Schwann Cells from Adult Human Skin and Nerve

eNeuro ◽  
2017 ◽  
Vol 4 (3) ◽  
pp. ENEURO.0307-16.2017 ◽  
Author(s):  
Jo Anne Stratton ◽  
Ranjan Kumar ◽  
Sarthak Sinha ◽  
Prajay Shah ◽  
Morgan Stykel ◽  
...  
Keyword(s):  
Schwann Cells ◽  
Human Skin ◽  
Purification And Characterization ◽  
Adult Human ◽  
Adult Human Skin

scholarly journals Functional Characterization of Muscarinic Receptors in Human Schwann Cells

2020 ◽  
Vol 21 (18) ◽  
pp. 6666
Author(s):  
Roberta Piovesana ◽  
Alessandro Faroni ◽  
Ada Maria Tata ◽  
Adam J. Reid
Keyword(s):  
Cell Proliferation ◽  
Schwann Cells ◽  
Muscarinic Receptor ◽  
Muscarinic Receptors ◽  
Functional Characterization ◽  
Receptor Subtypes ◽  
Muscarinic Receptor Subtypes ◽  
Selective Stimulation ◽  
Stimulation Of

Functional characterization of muscarinic cholinergic receptors in myelinating glial cells has been well described both in central and peripheral nervous system. Rat Schwann cells (SCs) express different muscarinic receptor subtypes with the prevalence of the M2 subtype. The selective stimulation of this receptor subtype inhibits SC proliferation, improving their differentiation towards myelinating phenotype. In this work, we describe for the first time that human SCs are cholinoceptive as they express several muscarinic receptor subtypes and, as for rat SCs, M2 receptor is one of the most abundant. Human SCs, isolated from adult nerves, were cultured in vitro and stimulated with M2 muscarinic agonist arecaidine propargyl ester (APE). Similarly to that observed in rat, M2 receptor activation causes a decreased cell proliferation and promotes SC differentiation as suggested by increased Egr2 expression with an improved spindle-like shape cell morphology. Conversely, the non-selective stimulation of muscarinic receptors appears to promote cell proliferation with a reduction of SC average cell diameter. The data obtained demonstrate that human SCs are cholinoceptive and that human cultured SCs may represent an interesting tool to understand their physiology and increase the knowledge on how the cholinergic stimulation may contribute to address human SC development in normal and pathological conditions.

scholarly journals Characterization of glial cell line-derived neurotrophic factor family receptor α-1 in peripheral nerve Schwann cells

2005 ◽  
Vol 95 (2) ◽  
pp. 537-543 ◽  
Author(s):  
Asako Hase ◽  
Fumiaki Saito ◽  
Hiroki Yamada ◽  
Ken Arai ◽  
Teruo Shimizu ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Cell Line ◽  
Glial Cell ◽  
Schwann Cells ◽  
Neurotrophic Factor

Establishment and characterization of spontaneously immortalized Schwann cells from murine model of globoid cell leukodystrophy (twitcher)

2002 ◽  
Vol 68 (5) ◽  
pp. 588-594 ◽  
Author(s):  
Jin-Song Shen ◽  
Kazuhiko Watabe ◽  
Xing-Li Meng ◽  
Hiroyuki Ida ◽  
Toya Ohashi ◽  
...  
Keyword(s):  
Schwann Cells ◽  
Murine Model ◽  
Globoid Cell Leukodystrophy ◽  
Globoid Cell ◽  
Immortalized Schwann Cells
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