A rational design of casting machine mold

Metallurgist ◽  
1972 ◽  
Vol 16 (1) ◽  
pp. 20-21
Author(s):  
V. F. Bannykh ◽  
G. A. Mashkov
Keyword(s):  
Rational Design ◽  
Casting Machine ◽  
Machine Mold

A new casting-machine mold

Metallurgist ◽  
1975 ◽  
Vol 19 (7) ◽  
pp. 498-499
Author(s):  
M. I. Sharapov
Keyword(s):  
Casting Machine ◽  
Machine Mold

Casting Mold Designing for Double-Chamber Throttle Valve

2013 ◽  
Vol 787 ◽  
pp. 445-449
Author(s):  
Ao Bing Wang ◽  
Xue Dong Wang ◽  
Zheng Dong Chen ◽  
Li Yong Ni ◽  
Xiao Qin Gu
Keyword(s):  
Die Casting ◽  
Casting Machine ◽  
Bottom Surface ◽  
Process Scheme ◽  
Molding Process ◽  
Valve Body ◽  
Throttle Valve ◽  
Machine Mold ◽  
Die Castings ◽  
Double Chamber

The structure and processing of double chamber throttle valve body castings were analyzed. Die-casting molding process scheme was established. The design of mold includes three core-drawing mechanisms. Considering the large parts surface area and the relatively small wall thickness and the requirement of parting, the gate was arranged on the casting bottom surface. For economy and die easy maintenance considerations, die-casting machine, mold, and mold standard parts should be standard parts. The designs of mold gating system and non-standard pieces were completed. Proved by actual production, the mold operated smoothly, without clamping stagnation, and the production of die castings meet delivery requirements.

Casting Mold Designing for Aluminum Alloy Car Holders

2013 ◽  
Vol 378 ◽  
pp. 350-354
Author(s):  
Xue Dong Wang ◽  
Jian He Lin ◽  
Suo Qing Yu ◽  
Li Yong Ni
Keyword(s):  
Aluminum Alloy ◽  
Die Casting ◽  
Casting Machine ◽  
Bottom Surface ◽  
Gating System ◽  
Process Scheme ◽  
Molding Process ◽  
Casting Mold ◽  
Machine Mold ◽  
Die Castings

The structure and processing of car holders castings were analyzed. Die-casting molding process scheme was established. The design of mold includes three core-drawing mechanisms. the gate of the gating system was arranged on the casting bottom surface. For economy and die easy maintenance considerations, die-casting machine, mold, and mold standard parts should be standard parts. The designs of mold gating system and non-standard pieces were completed with the aid of PROE. Proved by actual production, the mold operated smoothly, without clamping stagnation, and the production of die castings meet delivery requirements.

scholarly journals Improvement of the Data Processing Algorithm for Diagnostic System of the State of Continuous Casting Machine Mold

2019 ◽  
Vol 24 (1) ◽  
pp. 35-41
Author(s):  
Viktor Oleksandrovich Didenko ◽  
Yuliia Valeriivna Bondarenko ◽  
Ievhen Volodymyrovych Verbytskyi ◽  
Oleksandr Fedorovych Bondarenko
Keyword(s):  
Continuous Casting ◽  
Data Processing ◽  
Continuous Casting Machine ◽  
Casting Machine ◽  
Diagnostic System ◽  
The State ◽  
Processing Algorithm ◽  
Data Processing Algorithm ◽  
Machine Mold

Molecular insights on the dynamic stability of peptide nucleic acid functionalized carbon and boron nitride nanotubes

2021 ◽  
Vol 23 (1) ◽  
pp. 219-228
Author(s):  
Nabanita Saikia ◽  
Mohamed Taha ◽  
Ravindra Pandey
Keyword(s):  
Nucleic Acid ◽  
Boron Nitride ◽  
Nucleic Acids ◽  
Dynamic Stability ◽  
Peptide Nucleic Acid ◽  
Rational Design ◽  
Peptide Nucleic Acids ◽  
Boron Nitride Nanotubes ◽  
Molecular Hybrids ◽  
Single Wall Nanotubes

The rational design of self-assembled nanobio-molecular hybrids of peptide nucleic acids with single-wall nanotubes rely on understanding how biomolecules recognize and mediate intermolecular interactions with the nanomaterial's surface.

Optimizing electron density of nickel sulfide electrocatalysts through sulfur vacancy engineering for alkaline hydrogen evolution

2020 ◽  
Vol 8 (35) ◽  
pp. 18207-18214
Author(s):  
Dongbo Jia ◽  
Lili Han ◽  
Ying Li ◽  
Wenjun He ◽  
Caichi Liu ◽  
...  
Keyword(s):  
Hydrogen Evolution ◽  
Electron Density ◽  
Rational Design ◽  
Nickel Sulfide ◽  
Catalytic Performance ◽  
Sulfide Catalysts ◽  
Sulfur Vacancy

A novel, rational design for porous S-vacancy nickel sulfide catalysts with remarkable catalytic performance for alkaline HER.

Rational design of annotine analogues with increased inhibitory activity towards acetylcholinesterase

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
ES Halldorsdottir ◽  
S Oddsson ◽  
AM Einarsdottir ◽  
B Eiriksdottir ◽  
NM Kowal ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Rational Design

Anticoagulant Activity of Hirulog™, a Direct Thrombin Inhibitor, in Humans

1993 ◽  
Vol 69 (02) ◽  
pp. 157-163 ◽  
Author(s):  
Irving Fox ◽  
Adrian Dawson ◽  
Peter Loynds ◽  
Jane Eisner ◽  
Kathleen Findlen ◽  
...  
Keyword(s):  
Rational Design ◽  
Therapeutic Potential ◽  
Anticoagulant Activity ◽  
Subcutaneous Administration ◽  
Direct Thrombin Inhibitor ◽  
Controlled Study ◽  
Thrombin Inhibitor ◽  
Thrombin Time ◽  
Thrombotic Disease ◽  
Dose Dependent

SummaryHirulog™ (BG8967) is a direct thrombin inhibitor built by rational design using the protein hirudin as a model (Maraganore et al. [1990]; Biochemistry 29: 7095–101). In order to evaluate the therapeutic potential for hirulog in the management of thrombotic disease, the tolerability and anticoagulant activity of the agent were examined in a study of human volunteers.In a randomized, placebo-controlled study (n = 54), the intravenous infusion of hirulog over 15 min showed a rapid, dose-dependent prolongation of activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT). There was a corresponding dose-dependent increase in plasma hirulog levels. The peptide was rapidly cleared with a half-life of 36 min and a total body clearance rate for the peptide of 0.43 1 kg−1 h−1. Similar activity was observed following subcutaneous injection but with sustained pharmacodynamic and pharmacokinetic behavior. There was a significant correlation between pharmacokinetic and pharmacodynamic variables for both intravenous (r = 0.8, p <0.001) and subcutaneous administration (r = 0.7, p = 0.002).To evaluate the possible interactions of aspirin on the tolerability and anticoagulant activity of intravenous hirulog, a cross-over design was employed in eight subjects. Aspirin administration did not modify the peptide’s activity. At the administered dose of 0.6 mg kg−1 h−1 for 2 h, hirulog infusion prolonged APTT from 230 to 260% baseline. The infusion of hirulog in subjects who had received aspirin was not associated with any significant changes in the template bleeding time.The final phase of the study examined the activity and tolerability of hirulog in ten subjects during prolonged intravenous infusions for up to 24 h. The peptide (0.3 mg kg−1 h−1) exhibited sustained anticoagulant activity with no evidence for a cumulative effect. During hirulog infusion, APTT was prolonged from 210 to 250% baseline.In all phases of the study, hirulog administration was generally well-tolerated.Our observations show that hirulog is an active antithrombin agent with excellent tolerability in humans. As a direct thrombin inhibitor, hirulog provides a novel approach for the management of thrombotic disease.

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