Bovine pericardium for heart valve bioprostheses:in vitro andin vivo characterization of new chemical treatments

1994 ◽  
Vol 5 (12) ◽  
pp. 850-854 ◽  
Author(s):  
E. Pasquino ◽  
S. Pascale ◽  
M. Andreon ◽  
S. Rinaldi ◽  
F. Laborde ◽  
...  
Author(s):  
Robert Guidoin ◽  
Taniela Marli Bes ◽  
Tomas Francisco Cianciulli ◽  
Julianne Klein ◽  
Bin Li ◽  
...  

Fuel ◽  
1996 ◽  
Vol 75 (13) ◽  
pp. 1549-1556 ◽  
Author(s):  
Igor E. Nosyrev ◽  
Rene Gruber ◽  
Denise Cagniant ◽  
Andrzej Krzton ◽  
Janusz Pajak ◽  
...  

Author(s):  
Scott C. Corbett ◽  
Neil Verma ◽  
Parnian Boloori Zadeh ◽  
Ahmet U. Coskun ◽  
Hamid N.-Hashemi

While heart valve prostheses have been used successfully since 1960, 10-year survival rates still range from 37–58% [1]. The underlying problem with bioprostheses is a limited life from structural changes such as calcification and leaflet wear, leading to valve failure [2]. Biological tissue fixation and methods used to mount the tissue to a supporting stent can be blamed for this shortcoming. The underlying problem with mechanical heart valves is the presence of a centrally located leaflet, or occluder. It propagates high velocity jets, turbulence and areas of stagnation: the disturbances which necessitate anticoagulation [3]. A polyurethane valve has the potential to improve upon the shortcomings of existing valves and ultimately improve patient survival.


2017 ◽  
Vol 7 (1) ◽  
pp. 53-58
Author(s):  
Yang Li ◽  
Zhigang Zhu ◽  
Jingli Ding ◽  
Wei Yang ◽  
Yi Gong ◽  
...  

Author(s):  
Caitlin Martin ◽  
Wei Sun

Bio-prosthetic heart valves (BHVs) with leaflets made of glutaraldehyde-treated bovine pericardium (GLBP), have been used extensively to replace diseased heart valves. BHVs display superior hemodynamics to mechanical valves and eliminate the need for anticoagulant therapy; however, they exhibit poor durability resulting from in vivo degradation and fatigue damage of the leaflets.


1976 ◽  
Vol 22 (12) ◽  
pp. 1743-1750 ◽  
Author(s):  
Ronald Yule ◽  
B. D. Barridge

Broth-grown cultures of Bacillus stearothermophilus strain NU-10 produce a bacteriocin which exerts lethal activity on other strains of the bacterium. Optimal production occurs during late maximum stationary phase of growth, at neutral pH, and 55–65 °C. The bacteriocin can be substantially purified by a combination of precipitations, centrifugations, and gel filtrations. The thermocin is composed of protein and carbohydrate. It is partially destroyed by proteolytic enzymes but is resistant to DNase, RNase, and various chemical treatments. The bacteriocin has a small molecular weight and exhibits considerable thermostability.


2006 ◽  
Vol 55 (8) ◽  
pp. 1135-1140 ◽  
Author(s):  
Ryota Nomura ◽  
Kazuhiko Nakano ◽  
Hirotoshi Nemoto ◽  
Kazuyo Fujita ◽  
Satoko Inagaki ◽  
...  

Streptococcus mutans, known to be an aetiologic agent of dental caries, also causes infective endocarditis (IE), although a comparison of isolates from the oral cavity and infected heart valve of the same patient has not been reported. In the present study, infected heart valve and dental plaque samples from a patient with IE were analysed. Broad-range PCR with DNA sequencing revealed that 50 clones from the dental plaque isolates were composed of oral streptococci and periodontopathic bacteria, whereas only Streptococcus mutans was detected in 50 clones from the heart valve. Eighteen strains of Streptococcus mutans were isolated from dental plaque and seven from the heart valve, and the biochemical properties of each were in accordance with those of Streptococcus mutans. DNA fingerprinting analysis revealed that all the oral isolates of Streptococcus mutans had similar patterns, which were different from those of the isolates from the infected heart valve. Western blotting using glucosyltransferase (GTF)-specific antiserum showed that the seven strains from the heart valve lacked the three types of intact GTF. In addition, the sucrose-dependent adhesion rates of these isolates were significantly lower than those of the oral isolates (P<0.001). Furthermore, the isolates from the heart valve were less susceptible to erythromycin and kanamycin. These results indicate that the properties of the Streptococcus mutans strains isolated from the infected valve were different from those of typical oral strains, which may be related to the effects of IE.


2005 ◽  
Vol 6 (4) ◽  
pp. 1858-1863 ◽  
Author(s):  
Lucksanaporn Tarachiwin ◽  
Jitladda Sakdapipanich ◽  
Koichi Ute ◽  
Tatsuki Kitayama ◽  
Yasuyuki Tanaka

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