Acetylene derivatives Communication 151 . Heterocyclic compounds XXVII. Synthesis of polycyclic ?-amino alcohols and their esters

1954 ◽  
Vol 2 (4) ◽  
pp. 655-667
Author(s):  
I. N. Nazarov ◽  
L. I. Ukhova ◽  
V. A. Rudenko
Keyword(s):  
Heterocyclic Compounds ◽  
Amino Alcohols ◽  
Acetylene Derivatives

Research Progress of N-Alkylation of Alcohol and Amine by "Hydrogen Reaction"

2021 ◽  
Vol 871 ◽  
pp. 312-317
Author(s):  
Si Min Feng ◽  
Qing Liu
Keyword(s):  
Natural Products ◽  
Heterocyclic Compounds ◽  
Amino Alcohols ◽  
New Method ◽  
Research Progress ◽  
Primary Alcohols ◽  
Ammonia Gas ◽  
Fine Chemical ◽  
Chemical Products ◽  
Amine Compounds

Amine compounds are widely found in natural products, pharmaceuticals and fine chemical products. Therefore, it is of great significance to develop methods for synthesizing amine compounds. Therefore, in recent years, a new method of synthesizing amines has been developed, namely "hydrogen borrowing reaction". This article reviews the alkylation of primary alcohols and amines, the cyclization of amino alcohols to form N-heterocyclic compounds, the reaction of diols and amines to form N-heterocyclic compounds, the reaction of alcohols and sulfonamides, and the reaction of alcohols and amines containing N heteroatoms , Alcohol and ammonia gas and ammonia to produce amine by hydrogen reaction research progress.

Synthetic Routes to 1,4,5,6-Tetrahydropyrimidines: An Overview and Recent Advances

2019 ◽  
Vol 23 (17) ◽  
pp. 1843-1856
Author(s):  
Aditya Bhattacharyya
Keyword(s):  
Carbonyl Compounds ◽  
Heterocyclic Compounds ◽  
Multicomponent Reactions ◽  
Biological Significance ◽  
Selective Reduction ◽  
Ring Expansion ◽  
Amino Alcohols ◽  
Review Article ◽  
Pharmacological Properties ◽  
Synthetic Routes

Partially reduced heterocyclic compounds such as 1,4,5,6-tetrahydropyrimidines are often found to possess interesting pharmacological properties. Yet, the synthetic routes towards such systems are less developed than their fully aromatic counterparts. In this review article, the biological significance of 1,4,5,6-tetrahydropyrimidines is discussed and the existing literature reports describing various preparative routes to access 1,4,5,6-tetrahydropyrimidine derivatives have been categorically described. The focus has been expanded to present an overview of the chronological development of the traditional synthetic routes as well as the contemporary approaches to 1,4,5,6-tetrahydropyrimidines that generally include: (i) condensation reactions of diamines with various appropriate counterparts such as carbonyl compounds, imino ethers, amidines or nitriles, condensation of amidines with 1,3-dibromopropane and α,β-unstaurated carbonyl compounds, condensation of amino alcohols; (ii) selective reduction of pyrimidines; (iii) ring expansion chemistry of cyclopropanes, aziridines, and azetidines; and (iv) miscellaneous examples such as various multicomponent reactions.

Sign in / Sign up

Export Citation Format

Share Document