Enzymatic model of the pharmacokinetics of phenazepam in the mouse organism

1980 ◽  
Vol 14 (12) ◽  
pp. 833-837
Author(s):  
N. Ya. Golovenko ◽  
V. G. Zin'kovskii ◽  
S. B. Seredenin
Keyword(s):  
Enzymatic Model ◽  
Mouse Organism

Enzymatic model for receptor activation of GTP-binding regulatory proteins

1987 ◽  
Vol 12 ◽  
pp. 473-477 ◽  
Author(s):  
Marianne Wessling-Resnick ◽  
Daniel J. Kelleher ◽  
Ellen R. Weiss ◽  
Gary L. Johnson
Keyword(s):  
Receptor Activation ◽  
Regulatory Proteins ◽  
Gtp Binding ◽  
Enzymatic Model

A Model Mechanism for the Enzymatic Synthesis of Lupin Alkaloids

1979 ◽  
Vol 34 (9-10) ◽  
pp. 704-708 ◽  
Author(s):  
Michael Wink ◽  
Thomas Hartmann ◽  
Hans-M artin Schiebel
Keyword(s):  
Enzyme System ◽  
Cell Suspension Cultures ◽  
Gas Liquid Chromatography ◽  
Alkaloid Biosynthesis ◽  
Tracer Studies ◽  
Lupinus Polyphyllus ◽  
Crude Enzyme Preparation ◽  
Enzymatic Model ◽  
Hypothetical Mechanism

Abstract A crude enzyme preparation obtained from cell suspension cultures of Lupinus polyphyllus catalyzes the pyruvate dependent conversion of cadaverine into the tetracyclic lupin alkaloids. As the first reaction product 17-oxosparteine could be identified by gas-liquid chromatography and mass spectroscopy. In some experiments sparteine was found additionally. A participation of di­amine oxidase could be ruled out. The cadaverine-pyruvate transaminating enzyme system (17-oxosparteine synthase) catalyzes the formation of 17-oxosparteine from three cadaverine units without releasing free intermediates. These results are inconsistent with the hypothetical mechanism thus far formulated for the lupin alkaloid biosynthesis. A new enzymatic model mechanism is proposed regarding both the results of the enzymatic experiments and those of the in vivo tracer studies.

Der Redox-Zyklus von Phenanthrenchinon in Ascites-Tumorzellen und in einem vereinfachten Modell

1962 ◽  
Vol 17 (5) ◽  
pp. 322-325 ◽  
Author(s):  
H. J. Risse ◽  
H. Tiedemann
Keyword(s):  
Oxygen Uptake ◽  
Ehrlich Ascites Carcinoma ◽  
Carcinoma Cells ◽  
Redox Cycle ◽  
Aerobic Conditions ◽  
Quinone Reduction ◽  
Ehrlich Ascites ◽  
Enzymatic Model

Phenanthraquinone (9, 10) added to Ehrlich-Ascites carcinoma cells under aerobic conditions is involved in a redox-cycle. During the autoxydation of the reduced quinone radicals and H2O2 were formed, which are responsible for the carcinostatic action of the quinone. The number of the runs through the redox-cycle is calculated from the oxygen uptake during the autoxidation. The frequency of carrying out the cycle is limited from the rate of quinone-reduction. The cycle can be reproduced in a non enzymatic model using cysteine as a hydrogen donator.

On the electrochemical study of an enzymatic model reaction

1994 ◽  
Vol 6 (11-12) ◽  
pp. 1119-1125
Author(s):  
Teresa Pineda ◽  
Manuel Blazquez
Keyword(s):  
Model Reaction ◽  
Electrochemical Study ◽  
Enzymatic Model

Analytical Estimation of Water Contents, Specific Heat Capacity and Thermal Profiles Associated with Enzymatic Model Compound β-Cyclodextrin

2018 ◽  
Vol 114 (12) ◽  
pp. 2525 ◽  
Author(s):  
Gaurav R. Gupta ◽  
Pankaj D. Patil ◽  
Vasim R. Shaikh ◽  
Rahul R. Kolhapurkar ◽  
Dilip H. Dagade ◽  
...  
Keyword(s):  
Heat Capacity ◽  
Specific Heat ◽  
Specific Heat Capacity ◽  
Model Compound ◽  
Analytical Estimation ◽  
Enzymatic Model ◽  
Water Contents
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