Ultrastructure of the mamillary body

1969 ◽  
Vol 3 (3) ◽  
pp. 84-90
Author(s):  
A. L. Mikeladze ◽  
I. L. Lazriev
Keyword(s):  
Mamillary Body

Mamillary Body Lesions in Monkeys Impair Object-in-Place Memory: Functional Unity of the Fornix-Mamillary System

1997 ◽  
Vol 9 (4) ◽  
pp. 512-521 ◽  
Author(s):  
Amanda Parker ◽  
David Gaffan
Keyword(s):  
Episodic Memory ◽  
Memory Task ◽  
Control Group ◽  
Thalamic Nuclei ◽  
Mamillary Body ◽  
Control Operation ◽  
Place Memory ◽  
Severe Impairment ◽  
Anterior Thalamic Nuclei

Six monkeys were trained preoperatively in an automated object-in-place memory task in which they learned 20 new scenes in each daily session. Three of the six monkeys then received stereotaxically guided bilateral mamillary body lesions, leaving the fornix intact, while the other three received a control operation. Postoperatively the control animals' rate of learning new scenes was unchanged, but the animals with mamillary body lesions showed a severe impairment, equal to that seen in previous experiments after fornix transection. All six animals were then given fornix transection, in addition to the existing mamillary or control operation. The control group now showed, after fornix transection, an impairment equal to that of the animals with mamillary body lesions alone. But the animals with mamillary body lesions did not show any additional impairment following fornix transection. We conclude that (1) the role of the mamillary bodies in a model of human episodic memory is as important as the role of the fornix, (2) the fornix and mamillary bodies form a single functional memory system, since the effect of lesions in both parts is no more severe than the effects of a lesion in one of the parts alone, and (3) the idea that the functional effects of fornix transection result from cholmergic deafferentation of the hippocampus receives no support from the present results; rather, they support the idea that in primates the fornix and mamillary bodies, together with connected structures, including the subiculum, mamillo-thalamic tract, anterior thalamic nuclei, and cingulate bundle, form a cortico-cortical association pathway for episodic memory.

Model for Korsakoff-Type Amnesias: Negative Effects from the Amygdala and Mamillary Body

1978 ◽  
Vol 43 (3) ◽  
pp. 767-770 ◽  
Author(s):  
B. P. H. Poschel ◽  
F. W. Ninteman
Keyword(s):  
Food Pellet ◽  
Learning Ability ◽  
Male Rats ◽  
Negative Effects ◽  
Mamillary Body ◽  
Hippocampal Stimulation ◽  
Set Up ◽  
Intracranial Electrodes ◽  
Stimulation Of ◽  
Daily Test

Intracranial electrodes were implanted bilaterally in the anterior area of the amygdala ( n = 7), or unilaterally in the mamillary body ( n = 6) of Hot: (SD) male rats. The rats were then trained to run back and forth to obtain food pellets at either end of a runway. At the midpoint were two adjacent doorways. Passing through the correct doorway set up food-pellet delivery. Passing through the incorrect doorway merely registered as an error. Daily test sessions lasted 25 min., and accumulated correct and incorrect runs were recorded for each session. The doorway designated as correct was changed each day throughout the training and testing period. On those days when the effects on learning of stimulation of the amygdalae or mamillary body were tested, the electrical brain stimulation was administered just prior to placing the rat in the runway. No detrimental effects on learning were associated with electrical stimulation of either brain structure. These findings are contrasted with our earlier study of hippocampal stimulation, which showed large deficits in learning ability.

Morphologic and Volumetric Analysis of Amygdala, Hippocampus, Fornix and Mamillary Body with MRI in Patients with Temporal Lobe Epilepsy

2006 ◽  
Vol 19 (3) ◽  
pp. 289-296 ◽  
Author(s):  
B. Hakyemez ◽  
K. Yucel ◽  
N. Yildirim ◽  
C. Erdogan ◽  
I. Bora ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Volumetric Analysis ◽  
Mamillary Body

scholarly journals Prevalence of Asymmetry of Mamillary Body and Fornix Size on MR Imaging

2008 ◽  
Vol 29 (2) ◽  
pp. 384-387 ◽  
Author(s):  
A. Ozturk ◽  
D.M. Yousem ◽  
A. Mahmood ◽  
S. el Sayed
Keyword(s):  
Mr Imaging ◽  
Mamillary Body
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