Effect of HDL1 infusion on biliary secretion in perfused rat liver

1992 ◽  
Vol 12 (5) ◽  
pp. 425-432 ◽  
Author(s):  
Roberto Rivabene ◽  
Alfredo Cantafora ◽  
Chong Chao Yan ◽  
Flavia Castellano ◽  
Giovannella Bruscalupi ◽  
...  
Keyword(s):  
Rat Liver ◽  
In Vitro Model ◽  
Significant Rise ◽  
Molar Ratio ◽  
Strong Increase ◽  
Perfused Rat Liver ◽  
Biliary Lipid ◽  
Liver Membrane ◽  
Vitro Model

The effects of HDL1 lipoprotein infusion on biliary lipid secretion were studied in the in vitro model of rat perfused liver. A strong increase in bile flow was observed during and after lipoprotein infusion. This caused a significant rise in cholesterol, phospholipid and bile salt secretions. However, only the percentage of cholesterol increased with respect to the other bile lipids. The changes observed in the cholesterol/phospholipid molar ratio values of liver membrane subfractions (i.e., liver plasma membrane, mitochondria plus lysosomes and microsomes) isolated from the perfused rat liver after HDL1 administration were not significant.

scholarly journals Recellularization of rat liver: An in vitro model for assessing human drug metabolism and liver biology

PLoS ONE ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. e0191892 ◽  
Author(s):  
Matthew J. Robertson ◽  
Benjamin Soibam ◽  
Jacqueline G. O’Leary ◽  
Luiz C. Sampaio ◽  
Doris A. Taylor
Keyword(s):  
Drug Metabolism ◽  
Rat Liver ◽  
In Vitro Model ◽  
Vitro Model

Insulin resistance in uremia: In vitro model in the rat liver using human serum to study mechanisms

Metabolism ◽  
1986 ◽  
Vol 35 (11) ◽  
pp. 989-998 ◽  
Author(s):  
Franco Folli ◽  
Madhur K. Sinha ◽  
Diego Brancaccio ◽  
Jose F. Caro
Keyword(s):  
Insulin Resistance ◽  
Human Serum ◽  
Rat Liver ◽  
In Vitro Model ◽  
Vitro Model

An in vitro model for investigation of vitamin A effects on wound healing

2021 ◽  
pp. 1-6
Author(s):  
Hoda Keshmiri Neghab ◽  
Mohammad Hasan Soheilifar ◽  
Gholamreza Esmaeeli Djavid
Keyword(s):  
Wound Healing ◽  
Endothelial Cell ◽  
Vitamin A ◽  
In Vitro Model ◽  
Cellular Proliferation ◽  
Endothelial Cell Migration ◽  
Normal Fibroblast ◽  
Anti Inflammatory ◽  
Vitro Model

Abstract. Wound healing consists of a series of highly orderly overlapping processes characterized by hemostasis, inflammation, proliferation, and remodeling. Prolongation or interruption in each phase can lead to delayed wound healing or a non-healing chronic wound. Vitamin A is a crucial nutrient that is most beneficial for the health of the skin. The present study was undertaken to determine the effect of vitamin A on regeneration, angiogenesis, and inflammation characteristics in an in vitro model system during wound healing. For this purpose, mouse skin normal fibroblast (L929), human umbilical vein endothelial cell (HUVEC), and monocyte/macrophage-like cell line (RAW 264.7) were considered to evaluate proliferation, angiogenesis, and anti-inflammatory responses, respectively. Vitamin A (0.1–5 μM) increased cellular proliferation of L929 and HUVEC (p < 0.05). Similarly, it stimulated angiogenesis by promoting endothelial cell migration up to approximately 4 fold and interestingly tube formation up to 8.5 fold (p < 0.01). Furthermore, vitamin A treatment was shown to decrease the level of nitric oxide production in a dose-dependent effect (p < 0.05), exhibiting the anti-inflammatory property of vitamin A in accelerating wound healing. These results may reveal the therapeutic potential of vitamin A in diabetic wound healing by stimulating regeneration, angiogenesis, and anti-inflammation responses.

A new in vitro model for pre-transplantation diagnosis of frozen/thawed human ovarian tissue

2011 ◽  
Vol 71 (05) ◽  
Author(s):  
M Salama ◽  
K Winkler ◽  
KF Murach ◽  
S Hofer ◽  
L Wildt ◽  
...  
Keyword(s):  
In Vitro Model ◽  
Ovarian Tissue ◽  
Human Ovarian Tissue ◽  
Vitro Model
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