Characterization of a human granulocyte differentiation antigen (CDw15) commonly recognized by monoclonal antibodies

1985 ◽  
Vol 5 (10-11) ◽  
pp. 933-941 ◽  
Author(s):  
Noirin C. McCarthy ◽  
Merete T. Albrechtsen ◽  
M. A. Kerr
Keyword(s):  
Monoclonal Antibodies ◽  
Cell Surface ◽  
Cell Types ◽  
Carbohydrate Antigen ◽  
Differentiation Antigen ◽  
Molecular Weights ◽  
Wide Range ◽  
Cell Surface Glycoproteins ◽  
Surface Glycoproteins

Many different anti-human granulocyte monoclonal antibodies recognize the same carbohydrate antigen which contains the trisaccharide 3-fucosyl-N-acetyllactosamine. The antigen is expressed mainly on two cell surface glycoproteins of molecular weights around 105 K and 160K which are apparently not members of the LFA-1 family of proteins. Although specific for granulocytes in blood, the antigen is expressed on a wide range of non-haemopoietic cell types.

Cell surface glycoproteins of rabbit lymphocytes: Characterization with monoclonal antibodies

1984 ◽  
Vol 21 (1) ◽  
pp. 95-103 ◽  
Author(s):  
John M. Wilkinson ◽  
Debra L. Wetterskog ◽  
John A. Sogn ◽  
Thomas J. Kindt
Keyword(s):  
Monoclonal Antibodies ◽  
Cell Surface ◽  
Rabbit Lymphocytes ◽  
Cell Surface Glycoproteins ◽  
Surface Glycoproteins

scholarly journals Production of Monoclonal Antibodies Directed against Carbohydrate Moieties of Cell Surface Glycoproteins

1988 ◽  
Vol 79 (10) ◽  
pp. 1119-1129 ◽  
Author(s):  
Shigeyuki Fukui ◽  
Yoshito Numata ◽  
Akira Kurosaka ◽  
Hiroshi Kitagawa ◽  
Hiroshi Nakada ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Cell Surface ◽  
Cell Surface Glycoproteins ◽  
Surface Glycoproteins

scholarly journals Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen Mac-1.

1981 ◽  
Vol 154 (5) ◽  
pp. 1517-1524 ◽  
Author(s):  
I S Trowbridge ◽  
M B Omary
Keyword(s):  
Monoclonal Antibodies ◽  
Cell Types ◽  
Surface Structures ◽  
Differentiation Antigen ◽  
Antigenic Analysis ◽  
Macrophage Differentiation ◽  
Hematopoietic System ◽  
Cell Surface Structures ◽  
Molecular Complexity ◽  
Surface Glycoproteins

Monoclonal antibodies have been obtained that react with the murine leukocyte surface glycoproteins bearing the macrophage differentiation antigen Mac-1. Structural and antigenic analysis shows that related glycoproteins are found on other murine hematopoietic cell types. The data not only illustrate the complexity of cell surface structures that can be detected by means of monoclonal antibodies, but also raise questions as to the functional significance of this family of molecules within the hematopoietic system.

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