Effect of a cold stimulus on the synthesis of uncoupling protein in brown adipose tissue of rats and newborn rabbits

1985 ◽  
Vol 5 (1) ◽  
pp. 57-62 ◽  
Author(s):  
John Arnold ◽  
Hasmukh V. Patel ◽  
Robert G. Ridley ◽  
Karl B. Freeman
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Uncoupling Protein ◽  
Cold Stimulus ◽  
Uncoupling Protein 3 ◽  
Brown Adipose ◽  
Old Rats

Rats are known to respond to a cold stimulus by increasing the activity and amount of the uncoupling protein in brown adipose tissue. A 48 h cold stimulus was found to increase the synthesis of uncoupling protein 3.g-fold in 4–5 week old rats whereas no change was observed with newborn rabbits. The lack of response in the latter case may reflect a difference between rabbits and rats or that synthesis is already maximal in newborn rabbits.

Absence of uncoupling protein 3 at thermoneutrality influences brown adipose tissue mitochondrial functionality in mice

2020 ◽  
Vol 34 (11) ◽  
pp. 15146-15163
Author(s):  
Elena Silvestri ◽  
Rosalba Senese ◽  
Rita De Matteis ◽  
Federica Cioffi ◽  
Maria Moreno ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Uncoupling Protein ◽  
Uncoupling Protein 3 ◽  
Brown Adipose

Brown Adipose Tissue and Its Uncoupling Protein in Chronically Hypoxic Rats

1997 ◽  
Vol 93 (4) ◽  
pp. 349-354 ◽  
Author(s):  
Jacopo P. Mortola ◽  
Lina Naso
Keyword(s):  
Adipose Tissue ◽  
Ambient Temperature ◽  
Brown Adipose Tissue ◽  
Body Mass ◽  
Uncoupling Protein ◽  
Total Proteins ◽  
Tissue Mass ◽  
Brown Adipose ◽  
Adipose Tissue Mass ◽  
Old Rats

1. Hypoxia is known to decrease thermogenesis. We set out to determine whether this is accompanied by alterations in the brown adipose tissue, which is a major source of non-shivering thermogenesis. 2. Measurements were performed on 25- and 64-day-old rats, after 4 days of hypoxia (10% inspired O2), and on ∼3.5-month-old rats in hypobaric hypoxia since birth, at an ambient temperature of 25°C. 3. All hypoxic rats had higher haematocrit and lower body mass than corresponding controls. 4. In the 25-day-old rats, hypoxia had minimal and non significant effects on brown adipose tissue mass, proteins and DNA concentration. The content of the mitochondrial uncoupling protein thermogenin, evaluated by immunoblot after electrophoretic separation, relative to the cytoskeleton actin (UCP/Act), was not significantly altered. 5. In 25-day-old rats exposed for 4 days to cold (ambient temperature = 7–9°C), brown adipose tissue was hyperplastic, with increased UCP/Act; hypoxia did not appreciably alter the response to cold. 6. In the 2-month-old rats, after 4 days of hypoxia UCP/Act was reduced to about 40% of control. 7. In the 3.5-month-old rats maintained in hypoxia since birth, brown adipose tissue mass was reduced in proportion to body mass, with little effect on total proteins and DNA; UCP/Act was decreased to about 50% of control. 8. We conclude that chronic hypoxia had a minimal effect on brown adipose tissue total proteins and DNA content. However, the uncoupling protein content can be greatly reduced, depending upon age and duration of hypoxia.

scholarly journals Endurance training blocks uncoupling protein 1 up-regulation in brown adipose tissue while increasing uncoupling protein 3 in the muscle tissue of rats fed with a high-sugar diet

2012 ◽  
Vol 32 (9) ◽  
pp. 709-717 ◽  
Author(s):  
Karina Barbosa de Queiroz ◽  
Gisele Vieira Rodovalho ◽  
Juliana Bohnen Guimarães ◽  
Daniel Carvalho de Lima ◽  
Cândido Celso Coimbra ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Endurance Training ◽  
Muscle Tissue ◽  
Uncoupling Protein ◽  
Uncoupling Protein 1 ◽  
High Sugar ◽  
Uncoupling Protein 3 ◽  
Brown Adipose

Discordance Between Thermogenic Activity and Expression of Uncoupling Protein in Brown Adipose Tissue of Old Rats

1994 ◽  
Vol 49 (2) ◽  
pp. B54-B59 ◽  
Author(s):  
H. Yamashita ◽  
M. Yamamoto ◽  
T. Ookawara ◽  
Y. Sato ◽  
N. Ueno ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Uncoupling Protein ◽  
Brown Adipose ◽  
Old Rats

scholarly journals A single mutation in uncoupling protein of rat brown adipose tissue mitochondria abolishes GDP sensitivity of H+ transport.

1994 ◽  
Vol 269 (10) ◽  
pp. 7435-7438
Author(s):  
D.L. Murdza-Inglis ◽  
M. Modriansky ◽  
H.V. Patel ◽  
G. Woldegiorgis ◽  
K.B. Freeman ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Uncoupling Protein ◽  
Single Mutation ◽  
Brown Adipose
Sign in / Sign up

Export Citation Format

Share Document