Enhanced production of dolichol, but not dolichyl phosphate, in the earliest stages of rat liver regeneration

1986 ◽  
Vol 6 (4) ◽  
pp. 409-413 ◽  
Author(s):  
M. Marino ◽  
G. Bruscalupi ◽  
S. Spagnuolo ◽  
S. Leoni ◽  
M. T. Mangiantini ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Rat Liver ◽  
Physiological Significance ◽  
Regenerating Liver ◽  
Rat Liver Regeneration ◽  
Enhanced Production ◽  
Dolichyl Phosphate

The regenerating liver presents a changed ability to use mevalonate 16 hr after partial hepatectomy. The dolichol content and its synthesis from mevalonate is increased, while no variation of dolichyl-P and ubiquinone parameters are detectable. The greater amount ofmevalonate utilized to form dolichol, but not dolichyl-P, in this proliferating system, raises some questions about the physiological significance of these isoprenoid compounds and about their biosynthetic sequence.

Turnover of ribosomal 28S and 18S rRNA during rat liver regeneration

1983 ◽  
Vol 3 (8) ◽  
pp. 781-788 ◽  
Author(s):  
Emil N. Nikolov ◽  
Mariane D. Dabeva
Keyword(s):  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Rat Liver ◽  
18S Rrna ◽  
Regenerating Liver ◽  
Experimental Procedure ◽  
Rat Liver Regeneration ◽  
Synthesis And Degradation

The turnover of 28S and 18S rRNA was studied in the course of 12 d after partial hepatectomy, including the proliferative (1st to 5th d) and post-proliferative (6th to 12th d) phases of liver regeneration. Turnover data, as the day-to-day rates of synthesis and degradation of 28S and 18S rRNA, were obtained by employing a suitable experimental procedure for the estimation of the increase of the amount of rRNA in the regenerating liver. It was found that 28S and 18S rRNA are accumulated into the cytoplasm and degraded at identical rates both in the proliferative and post proliferative phases. The turnover of both rRNA moieties is markedly slower during the first 3 d of liver regeneration.

DEOXYCYTIDYLATE DEAMINASE LEVELS IN REGENERATING RAT LIVER

1961 ◽  
Vol 39 (6) ◽  
pp. 1043-1054 ◽  
Author(s):  
D. K. Myers ◽  
C. Anne Hemphill ◽  
Constance M. Townsend
Keyword(s):  
Dna Synthesis ◽  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Rat Liver ◽  
Deoxyribonucleic Acid ◽  
Regenerating Liver ◽  
Regenerating Rat Liver ◽  
High Level ◽  
Early Regeneration

Deoxycytidylate deaminase activity and net synthesis of deoxyribonucleic acid (DNA) in vivo were found to increase at approximately the same time during the early stages of liver regeneration. However, deaminase activity in the regenerating liver remained at a high level for 1 day after DNA synthesis had slowed down again during the later stages of regeneration. The increase in deaminase activity was restricted as a result of exposure to 600 r X radiation during early regeneration, but this effect only became evident 11–16 hours after the irradiation. Irradiation on the second day after partial hepatectomy, when deaminase levels in control regenerating livers were relatively constant, failed to affect the deaminase activity immediately but did produce a 40–50% decrease in activity 11–16 hours later. Other antimitotic agents, e.g., colchicine, had little effect on deaminase activity.

Effect of alpha2b interferon administration on rat liver regeneration process after partial hepatectomy

1995 ◽  
Vol 108 (4) ◽  
pp. A1186
Author(s):  
S. Theocharis ◽  
A. Margeli ◽  
N. Goutas ◽  
S. Skaltsas ◽  
A. Skopelitou ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Rat Liver ◽  
Regeneration Process ◽  
Rat Liver Regeneration

930 IDENTIFICATION OF MICRORNAS DURING RAT LIVER REGENERATION AFTER PARTIAL HEPATECTOMY AND MODULATION BY URSODEOXYCHOLIC ACID

2010 ◽  
Vol 52 ◽  
pp. S360-S361
Author(s):  
R.E. Castro ◽  
X. Zhang ◽  
D.M. Ferreira ◽  
P.M. Borralho ◽  
A.L. Sarver ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Ursodeoxycholic Acid ◽  
Partial Hepatectomy ◽  
Rat Liver ◽  
Rat Liver Regeneration

scholarly journals Ki-67 expression during rat liver regeneration after partial hepatectomy

Hepatology ◽  
1997 ◽  
Vol 26 (3) ◽  
pp. 573-578 ◽  
Author(s):  
C Gerlach ◽  
D Y Sakkab ◽  
T Scholzen ◽  
R Daßler ◽  
M R Alison ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Rat Liver ◽  
Ki 67 ◽  
Rat Liver Regeneration

Role of heparin-binding epidermal growth factor–like growth factor as a hepatotrophic factor in rat liver regeneration after partial hepatectomy

Hepatology ◽  
1995 ◽  
Vol 22 (5) ◽  
pp. 1584-1590 ◽  
Author(s):  
Shinichi Kiso ◽  
Sumio Kawata ◽  
Shinji Tamura ◽  
Shigeki Higashiyama ◽  
Nobuyuki Ito ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Rat Liver ◽  
Heparin Binding ◽  
Rat Liver Regeneration ◽  
Epidermal Growth

[366] ADENOSINE CAN ACCELERATE THE CELL CYCLE DURING RAT LIVER REGENERATION INDUCED BY PARTIAL HEPATECTOMY

2007 ◽  
Vol 46 ◽  
pp. S142-S143 ◽  
Author(s):  
E. Mendieta-Condado ◽  
V. Chagoya de Sanchez ◽  
R. Hernandez-Munoz
Keyword(s):  
Cell Cycle ◽  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Rat Liver ◽  
Rat Liver Regeneration
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