Zinc and the mitosis-inhibitory epidermal pentapeptide (EPP) form a stimulatory chelated dimer

1995 ◽  
Vol 287 (8) ◽  
pp. 735-739
Author(s):  
Kjell Elgjo ◽  
Karl L. Reichelt
Keyword(s):  
Epidermal Pentapeptide

The Epidermal Pentapeptide pyroGlu-Glu-Asp-Ser-GlyOH Inhibits Murine Hair Growth in vivo and in vitro

Dermatology ◽  
1991 ◽  
Vol 183 (3) ◽  
pp. 173-178 ◽  
Author(s):  
R. Paus ◽  
K.S. Stenn ◽  
K. Elgjo
Keyword(s):  
Hair Growth ◽  
Epidermal Pentapeptide

Moderate enhancement of the promotion phase of skin tumorigenesis in hairless mice by topical pretreatment with a mitosis-inhibiting epidermal pentapeptide

1993 ◽  
Vol 14 (12) ◽  
pp. 2537-2542 ◽  
Author(s):  
Olav Hilmar Iversen ◽  
Kjell Elgjo ◽  
Jan Erik Paulsen ◽  
Karl L. Reichelt
Keyword(s):  
Hairless Mice ◽  
Skin Tumorigenesis ◽  
Epidermal Pentapeptide

Synthetic epidermal pentapeptide and related growth regulatory peptides inhibit proliferation and enhance differentiation in primary and regenerating cultures of human epidermal keratinocytes

1990 ◽  
Vol 97 (1) ◽  
pp. 51-58 ◽  
Author(s):  
P.K. Jensen ◽  
K. Elgjo ◽  
O.D. Laerum ◽  
L. Bolund
Keyword(s):  
Primary Cultures ◽  
Mouse Skin ◽  
Regulatory Peptides ◽  
Epidermal Keratinocytes ◽  
Synthetic Analog ◽  
Proliferating Cells ◽  
Human Epidermal Keratinocytes ◽  
Epidermal Pentapeptide

A pentapeptide that inhibits proliferation of mouse epidermal keratinocytes in vivo and in vitro has been purified from mouse skin extracts. In the present study the effect of a synthetic analog of the epidermal pentapeptide on proliferation and differentiation of cultured human epidermal keratinocytes was investigated. In young, rapidly growing primary cultures the pentapeptide caused a dramatic decrease in mitotic activity and also induced pronounced changes in the balance between kinetically defined subpopulations of proliferating cells. A dipeptide derived from the pentapeptide was found to be at least as potent. A serine derivative of a hemoregulatory peptide also seemed to be active. When tested in epidermal cultures regenerating after removal of the suprabasal cell layers, both the pentapeptide and the dipeptide were shown to cause a delay in the proliferative response. Both peptides were also able to stimulate early (increase in cell size) and late (cornified envelope formation) events in the differentiation pathway of the keratinocyte. The apparent stimulatory effect on differentiation was most clearly seen in regenerating cultures, whereas the effect on primary cultures varied with the experimental set-up. It is suggested that homologous epidermal peptide(s) may play a major role in the regulation of human epidermal homeostasis.

Purified Epidermal Pentapeptide Inhibits Proliferation and Enhances Terminal Differentiation in Cultured Mouse Epidermal Cells

1986 ◽  
Vol 87 (5) ◽  
pp. 555-558 ◽  
Author(s):  
Kjell Elgjo ◽  
Karl L Reichelt ◽  
Henry Hennings ◽  
Delores Michael ◽  
Stuart H Yuspa
Keyword(s):  
Terminal Differentiation ◽  
Epidermal Cells ◽  
Epidermal Pentapeptide
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