Importance of cranial nerve involvement in nasopharyngeal carcinoma. A clinical study comprising 124 cases with special reference to clinical presentation and prognosis

1998 ◽  
Vol 21 (4) ◽  
pp. 243-248 ◽  
Author(s):  
Mehmet Turgut ◽  
�zcan Ert�rk ◽  
Serap Saygi ◽  
Osman E. �zcan
Keyword(s):  
Clinical Study ◽  
Nasopharyngeal Carcinoma ◽  
Special Reference ◽  
Cranial Nerve ◽  
Clinical Presentation ◽  
Cranial Nerve Involvement ◽  
Nerve Involvement

Cranial Nerve Involvement in Nasopharyngeal Carcinoma: Response to Radiotherapy and its Clinical Impact

2006 ◽  
Vol 115 (5) ◽  
pp. 340-345 ◽  
Author(s):  
Jian-Cheng Li ◽  
Nina A. Mayr ◽  
William T. C. Yuh ◽  
Jian Z. Wang ◽  
Guo-Liang Jiang
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Cranial Nerve ◽  
Clinical Impact ◽  
Cranial Nerve Involvement ◽  
Nerve Involvement

scholarly journals Cranial nerve involvement and base of the skull erosion in nasopharyngeal carcinoma

Cancer ◽  
1991 ◽  
Vol 68 (2) ◽  
pp. 422-426 ◽  
Author(s):  
Jonathan S. T. Sham ◽  
D. Choy ◽  
Y. K. Cheung ◽  
F. L. Chan ◽  
Lilian Leong
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Cranial Nerve ◽  
Cranial Nerve Involvement ◽  
Nerve Involvement ◽  
Base Of The Skull ◽  
Skull Erosion

Prognostic impact of magnetic resonance imaging-detected cranial nerve involvement in nasopharyngeal carcinoma

Cancer ◽  
2009 ◽  
Vol 115 (9) ◽  
pp. 1995-2003 ◽  
Author(s):  
Lizhi Liu ◽  
Shaobo Liang ◽  
Li Li ◽  
Yanping Mao ◽  
Linglong Tang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Nasopharyngeal Carcinoma ◽  
Cranial Nerve ◽  
Prognostic Impact ◽  
Resonance Imaging ◽  
Cranial Nerve Involvement ◽  
Nerve Involvement

scholarly journals T4-Locally Advanced Nasopharyngeal Carcinoma: Prognostic Influence of Cranial Nerve Involvement in Different Radiotherapy Techniques

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Hsin-I Huang ◽  
Kee-Tak Chan ◽  
Chih-Hung Shu ◽  
Ching-Yin Ho
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Cranial Nerve ◽  
Locally Advanced ◽  
Survival Rates ◽  
Disease Free Survival ◽  
Cranial Nerve Involvement ◽  
Free Survival ◽  
Nerve Involvement ◽  
Disease Free ◽  
3D Crt

Background. Cranial nerve involvement at disease presentation of nasopharyngeal carcinoma was not uncommon. We investigated the prognosis of patients with T4-locally advanced NPC, with or without cranial nerve involvement, and compared the outcome of patients treated using different radiotherapy techniques.Methods. In this retrospective study, 83 T4-locally advanced NPC patients were diagnosed according to the seventh edition of the American Joint Committee on Cancer staging system. All patients were treated using three-dimensional conformal radiotherapy (3D-CRT) or intensity-modulated radiation therapy (IMRT). The survival rate was analyzed using the Kaplan-Meier method.Results. The 5-year overall, locoregional-free, and disease-free survival rates of patients treated using IMRT were 88.9%, 75.2%, and 69.2%, respectively. The outcome in these patients was significantly better than that in patients treated using 3D-CRT, with survival rates of 58.2%, 54.4%, and 47.2%, respectively. There was no significant difference in the 5-year overall, locoregional-free, and disease-free survival rates of the patients with (64.2%, 60.5%, and 53.5%, resp.) and without (76.9%, 63.6%, and 57.6%, resp.) cranial nerve involvement.Conclusion. Locally advanced NPC patients treated using IMRT had significantly better outcomes than patients treated using 3D-CRT. Our results showed that the outcome of T4 NPC patients with or without cranial nerve involvement was not different.

scholarly journals Late presentation of nasopharyngeal carcinoma

2018 ◽  
Vol 1 (1) ◽  
pp. 21-22
Author(s):  
Alexandru Nicolaescu ◽  
Cristina Coman ◽  
Luminita Agachi
Keyword(s):  
Hearing Loss ◽  
Nasopharyngeal Carcinoma ◽  
Skull Base ◽  
Cranial Nerve ◽  
Locally Advanced ◽  
Disease Stage ◽  
Cranial Nerve Involvement ◽  
Nerve Involvement ◽  
Recurrent Epistaxis ◽  
The Right

Nasopharyngeal carcinoma has a tipically insidious presentation, with often neglected signs and symptoms, thus more than 99% of patients are symptomatic on diagnostic 1. There are 5 types of presentation models: the rhinologic type (nasal obstruction, epistaxis, rhinorrhea), the otologic type (otorrhea, conductive hearing loss), the lymphatic type (bulky cervical neck masses), the neurologic type (headache, cranial nerve palsy) and the opthalmic type (diplopia due to cranial nerve involvement - III, IV and VI). These presentation models are usually singular but will become associated as the disease progresses and the tumor extends, encompassing the skull base.  We present the case of a 51 y.o. male with bilateral neck massess which appeared approximatively 6 months ago, recurrent epistaxis after sneezing, unilateral (right) hearing loss and otorrhea, right side hypogeusia (partial loss of taste sense) of the tongue and hypoesthesia of the right hemiface, involving the mandible and cheek.  Naso-pharyngeal endoscopy showed a tumor involving the right lateral wall of the rhinopharynx as well as the posterior and superior walls and extending to the sphenoid sinuses and downward to the oropharynx. The tumor encompassed the Eustachian tube orifice - and the patient had otomastoiditis with persistent suppuration, consistent with otoscopy findings. Contrast CT scans showed skull base involvement, thus explaining cranial nerve involvement (mandibular branch of V). The diagnosis was locally advanced disease (stage IV) and a biopsy was performed, followed by a multi-modal radiation and chemotherapy protocol. Case particularity: late-onset presentation with rhinologic, neurologic, otic and lymphatic signs.  

Primary Intracranial Germinoma Presenting as Lower Cranial Nerve Involvement: Case Report and Review of the Literature

Neurosurgery ◽  
1984 ◽  
Vol 14 (4) ◽  
pp. 475-479
Author(s):  
Luis A. Aguila ◽  
Samuel M. Chou ◽  
Janet W. Bay
Keyword(s):  
Cranial Nerve ◽  
Unusual Case ◽  
Clinical Presentation ◽  
Review Of The Literature ◽  
Increased Intracranial Pressure ◽  
Cranial Nerve Involvement ◽  
Lower Cranial Nerve ◽  
Intracranial Germinoma ◽  
Nerve Involvement ◽  
Suprasellar Region

Abstract Primary intracranial germinomas are classically known as midline lesions, occurring most commonly in the pineal and suprasellar regions, and will usually present with symptoms related to increased intracranial pressure or hypothalmic dysfunction. Involvement of both the pineal and the suprasellar region in the same patient (double midline lesions) is relatively rare (7%). Dissemination of germinoma to both cerebellopontine angles, in addition to the double midline lesions, with the initial clinical presentation of lower cranial nerve involvement has not been previously reported. We encountered such an unusual case, which prompted this report and review of the literature.

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