Zonulae occludentes of the myelin lamellae in the nerve fibre layer of the retina and in the optic nerve of the rabbit: A demonstration by the freeze-fracture method

1975 ◽  
Vol 4 (2) ◽  
pp. 131-140 ◽  
Author(s):  
E. Reale ◽  
L. Luciano ◽  
M. Spitznas
Keyword(s):  
Optic Nerve ◽  
Nerve Fibre ◽  
Freeze Fracture ◽  
Zonulae Occludentes ◽  
Fibre Layer ◽  
Nerve Fibre Layer

Ethnic differences in optic nerve head and retinal nerve fibre layer thickness parameters in children

2009 ◽  
Vol 94 (7) ◽  
pp. 871-876 ◽  
Author(s):  
C. Samarawickrama ◽  
J. J. Wang ◽  
S. C. Huynh ◽  
A. Pai ◽  
G. Burlutsky ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Layer Thickness ◽  
Nerve Fibre ◽  
Ethnic Differences ◽  
Optic Nerve Head ◽  
Retinal Nerve Fibre Layer ◽  
Fibre Layer ◽  
Nerve Fibre Layer

Detecting optic nerve head swelling on ultrasound and optical coherence tomography in children and young people: an observational study

2017 ◽  
Vol 102 (3) ◽  
pp. 318-322 ◽  
Author(s):  
Annegret Hella Dahlmann-Noor ◽  
Gillian W Adams ◽  
Moritz Claudius Daniel ◽  
Alison Davis ◽  
Joanne Hancox ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Young People ◽  
Layer Thickness ◽  
Nerve Fibre ◽  
Diagnostic Workup ◽  
Optical Coherence ◽  
Children And Young People ◽  
Fibre Layer ◽  
Nerve Fibre Layer

BackgroundFollowing high-profile cases, referrals for evaluation of ‘suspicious optic discs’ to eye clinics in the UK have sharply increased, asking ophthalmologists to reliably distinguish between true and pseudopapilloedema. Optic nerve sheath dilatation (ONSD) on ocular ultrasound (US) is considered a reliable sign of true papilloedema, but this test is not widely available. Recently, anterior bowing of Bruch’s membrane (BM) and increased retinal nerve fibre layer thickness on optical coherence tomography (OCT) have emerged as indicators of intracranial hypertension, and OCT is widely available. We aimed to evaluate safety and efficacy of the diagnostic workup in our service, with particular emphasis of diagnostic reliability of US and OCT.MethodsRetrospective service evaluation/cohort study of children and young people younger than 16 years investigated for ‘suspicious discs’ over a 7-month period in 2016 at a single eye care provider in London, UK. 61 children and young people underwent clinical assessment, US scan and OCT.ResultsOf 61 cases, 3 had intracranial pathology. At presentation, only one had ONSD on US and anterior bowing of BM on OCT. Increased nerve fibre layer thickness in at least one of three relevant sectors was observed in two cases. All three cases of intracranial pathology, however, had significant points in their presenting or medical history.ConclusionOphthalmologists and optometrists must not rely on funduscopy and ocular imaging when assessing a child for possible intracranial disease; history and basic neurological assessment are critical in the diagnostic workup.

scholarly journals Spectral-domain OCT changes in retina and optic nerve in children with hypoxic–ischaemic encephalopathy

2020 ◽  
Author(s):  
L. Grego ◽  
S. Pignatto ◽  
E. Busolini ◽  
N. Rassu ◽  
F. Samassa ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Therapeutic Hypothermia ◽  
Nerve Fibre ◽  
Cerebral Oedema ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Control Group ◽  
Fibre Layer ◽  
Nerve Fibre Layer

Abstract Purpose To evaluate the effect of neonatal hypoxic–ischaemic injury on the retina and the optic nerve and to correlate ocular damage with systemic parameters, laboratory tests, neurological imaging and therapeutic hypothermia at birth. Methods Forty-one children with hypoxic–ischaemic encephalopathy (HIE) at birth (9.09 ± 3.78 years) and a control group of 38 healthy subjects (9.57 ± 3.47 years) were enrolled in a cohort study. The HIE population was divided into three subgroups, based on the degree of encephalopathy according to Sarnat score and the treatment with therapeutic hypothermia (TH): Sarnat score I not treated with hypothermia, Sarnat score II-III treated with TH and Sarnat score II-III not subjected to TH. Total macular thickness, individual retinal layers and peripapillary nerve fibre layer thickness were measured with spectral-domain optical coherence tomography. Clinical data of perinatal period of HIE children were collected: APGAR score, pH and base excess of funiculus blood at birth, apnoea duration, brain ultrasound, cerebral MRI ischaemic lesions and blood chemistry tests. Results Children with Sarnat score I did not show a reduction of peripapillary nerve fibres and ganglion cell layer compared to the control group (p = 0.387, p = 0.316). Peripapillary nerve fibre layer was 109.06 ± 7.79 μm in children with Sarnat score II-III treated with TH, 108.31 ± 7.83 μm in subjects with Sarnat score II-III not subjected to TH and 114.27 ± 6.81 μm in the control group (p = 0.028, p = 0.007). Ganglion cell layer was thinner in children with Sarnat score II-III treated with TH (50.31 ± 5.13 μm) compared to the control group (54.04 ± 2.81 μm) (p = 0.01). Inner retinal layers damage correlated with C-reactive protein and lactate dehydrogenase increase, while higher levels of total bilirubin were protective against retinal impairment (p < 0.05). Cerebral oedema was related to peripapillary nerve fibre layer damage (p = 0.046). Conclusions Thickness reduction of inner retinal layer and peripapillary nerve fibre impairment was related to encephalopathy severity. Ocular damage was associated with inflammation and cerebral oedema following hypoxic–ischaemic damage.

Long‐term capillary changes in areas of dissociated optic nerve fibre layer after macular hole surgery

2021 ◽  
Author(s):  
Rita Serra ◽  
Antonio Pinna ◽  
Paola Carlino ◽  
Ermete Giancipoli ◽  
Ramin Tadayoni ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Macular Hole ◽  
Nerve Fibre ◽  
Macular Hole Surgery ◽  
Fibre Layer ◽  
Optic Nerve Fibre ◽  
Nerve Fibre Layer
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